| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/11/2005 | at | College of Charleston |
| W 9-6 |
|
| 2/12/2005 | at | College of Charleston |
| L 15-7 |
|
| 2/13/2005 | at | College of Charleston |
| L 11-9 |
|
| 2/18/2005 | at | Coastal Carolina |
| L 11-5 | Baseball at the Beach, Myrtle Beach, SC |
| 2/19/2005 | vs | West Virginia |
| W 8-2 | Baseball at the Beach, Myrtle Beach, SC |
| 2/20/2005 | vs | Clemson |
| W 10-0 | Baseball at the Beach, Myrtle Beach, SC |
| 2/25/2005 | vs | West Virginia |
| W 13-2 | Homewood Suites Shootout II, Charleston, SC |
| 2/26/2005 | vs | North Carolina State |
| W 13-1 | Homewood Suites Shootout II, Charleston, SC |
| 2/27/2005 | at | The Citadel |
|
| PPD, rain (Homewood Suites Shootout II, Charleston, SC) |
| 3/4/2005 |
| Michigan |
| W 2-1 | Keith LeClair Invitational, Greenville, NC |
| 3/5/2005 |
| Arizona State |
| L 10-3 | Keith LeClair Invitational, Greenville, NC |
| 3/6/2005 |
| Georgia |
| W 7-1 | Keith LeClair Invitational, Greenville, NC |
| 3/8/2005 |
| North Carolina A&T |
| W 16-5 |
|
| 3/11/2005 |
| Navy |
|
| PPD to 3/12, rain |
| 3/12/2005 |
| Navy |
| W 6-5 |
|
| 3/12/2005 |
| Navy |
| W 17-4 | makeup of 3/11 game |
| 3/13/2005 |
| Navy |
| W 14-0 | Billy Richardson (ECU) hits for cycle |
| 3/15/2005 |
| High Point |
| W 14-5 |
|
| 3/16/2005 | at | North Carolina-Wilmington |
|
| PPD, inclement weather |
| 3/18/2005 | at | Tulane | * | L 6-5 |
|
| 3/19/2005 | at | Tulane | * | L 13-6 |
|
| 3/20/2005 | at | Tulane | * | L 8-6 |
|
| 3/23/2005 |
| North Carolina-Wilmington |
| W 12-8 |
|
| 3/25/2005 |
| North Carolina-Charlotte | * | L 6-2 |
|
| 3/26/2005 |
| North Carolina-Charlotte | * | L 9-6 |
|
| 3/26/2005 |
| North Carolina-Charlotte | * | W 6-0 | moved from 3/27, impending weather |
| 3/30/2005 |
| Campbell |
| W 6-5 |
|
| 4/1/2005 | at | Texas Christian | * | L 8-5 |
|
| 4/2/2005 | at | Texas Christian | * | W 10-5 |
|
| 4/3/2005 | at | Texas Christian | * | L 4-0 |
|
| 4/6/2005 | at | North Carolina State |
| L 11-4 |
|
| 4/8/2005 |
| Southern Mississippi | * | L 12-6 |
|
| 4/9/2005 |
| Southern Mississippi | * | W 7-5 |
|
| 4/10/2005 |
| Southern Mississippi | * | W 10-6 |
|
| 4/13/2005 |
| North Carolina |
|
| PPD, rain |
| 4/15/2005 | at | Louisville | * | W 4-1 |
|
| 4/16/2005 | at | Louisville | * | W 9-8 |
|
| 4/17/2005 | at | Louisville | * | W 11-6 |
|
| 4/19/2005 |
| North Carolina |
| L 18-6 |
|
| 4/20/2005 |
| North Carolina State |
| L 3-0 |
|
| 4/22/2005 |
| Memphis | * | W 12-0 |
|
| 4/23/2005 |
| Memphis | * | L 8-5 |
|
| 4/24/2005 |
| Memphis | * | W 3-0 | Ricky Brooks (ECU) throws no-hitter, one baserunner (strikeout, wild pitch) |
| 4/26/2005 | at | The Citadel |
| W 3-0 | makeup of 2/27 game |
| 4/29/2005 |
| Cincinnati | * | W 13-7 |
|
| 4/30/2005 |
| Cincinnati | * | L 3-2 | 10 innings |
| 5/1/2005 |
| Cincinnati | * | W 8-4 |
|
| 5/4/2005 | at | North Carolina-Wilmington |
| L 6-5 | makeup of 3/16 game |
| 5/6/2005 | at | South Florida | * | W 6-2 |
|
| 5/7/2005 | at | South Florida | * | W 12-3 |
|
| 5/8/2005 | at | South Florida | * | L 10-0 |
|
| 5/10/2005 |
| North Carolina State |
| L 3-0 |
|
| 5/11/2005 | at | North Carolina-Asheville |
| W 8-6 |
|
| 5/13/2005 | at | Alabama-Birmingham | * | W 18-5 |
|
| 5/14/2005 | at | Alabama-Birmingham | * | W 8-6 |
|
| 5/15/2005 | at | Alabama-Birmingham | * | W 6-5 |
|
| 5/17/2005 | at | North Carolina |
| L 8-5 |
|
| 5/19/2005 |
| St. Louis | * | W 8-7 |
|
| 5/20/2005 |
| St. Louis | * |
| suspended to 5/21, rain (7-3 ECU in 6th) |
| 5/21/2005 |
| St. Louis | * | W 9-5 | resumption of suspended game |
| 5/21/2005 |
| St. Louis | * | L 6-0 |
|
| 5/25/2005 | vs | Houston | CUSA-01 | W 6-5 | Conference USA Tournament, Game 1, Hattiesburg, MS |
| 5/26/2005 | vs | Tulane | CUSA-07 | L 16-3 | Conference USA Tournament, Game 7, Hattiesburg, MS |
| 5/27/2005 | vs | Houston | CUSA-09 | L 6-4 | Conference USA Tournament, Game 9, Hattiesburg, MS |
| 6/3/2005 | at | Arizona State |
| L 9-6 | Tempe Regional, Game 2 |
| 6/4/2005 | vs | Nevada-Las Vegas |
| L 5-3 | Tempe Regional, Game 3 |