| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/5/2005 |
| C Missouri (D2) |
| W 5-2 |
|
| 2/8/2005 |
| Sam Houston State |
|
| PPD, rain |
| 2/11/2005 | vs | Oklahoma State |
| W 8-4 | Minute Maid Park College Classic, Houston, TX |
| 2/12/2005 | vs | Texas A&M |
| W 3-1 | Minute Maid Park College Classic, Houston, TX |
| 2/13/2005 | vs | Baylor |
| L 6-1 | Minute Maid Park College Classic, Houston, TX |
| 2/15/2005 | at | Houston |
| W 7-6 |
|
| 2/18/2005 |
| Southwest Missouri State |
| W 8-2 | Coca Cola Classic, Houston, TX |
| 2/19/2005 |
| Mississippi |
| W 5-4 | Coca Cola Classic, Houston, TX |
| 2/20/2005 |
| Lamar |
| W 8-2 | Coca Cola Classic, Houston, TX |
| 2/22/2005 |
| Houston |
| W 4-3 |
|
| 2/25/2005 |
| Western Carolina |
| W 9-1 | Crowne Plaza/Rice Invitational, Houston, TX |
| 2/26/2005 |
| Nebraska |
|
| PPD to 2/27, rain (Crowne Plaza/Rice Invitational, Houston, TX) |
| 2/27/2005 |
| New Mexico |
|
| CCD, rain on Saturday (Crowne Plaza/Rice Invitational, Houston, TX) |
| 2/27/2005 |
| Nebraska |
| L 6-3 | makeup of 2/26 game (Crowne Plaza/Rice Invitational, Houston, TX) |
| 2/27/2005 |
| Western Carolina |
| W 8-4 | Crowne Plaza/Rice Invitational, Houston, TX |
| 3/1/2005 | at | Lamar |
| W 10-0 |
|
| 3/4/2005 | vs | Nebraska |
| L 4-3 | Round Rock College Classic, Round Rock, TX |
| 3/5/2005 | vs | Southern California |
| W 12-1 | Round Rock College Classic, Round Rock, TX |
| 3/6/2005 | vs | Notre Dame |
|
| CCD, rain (Round Rock College Classic, Round Rock, TX) |
| 3/9/2005 | at | Texas |
| L 7-0 |
|
| 3/11/2005 |
| Texas Christian |
| L 2-1 |
|
| 3/12/2005 |
| Texas Christian |
| W 15-5 |
|
| 3/13/2005 |
| Texas Christian |
| W 2-1 |
|
| 3/15/2005 |
| Purdue |
| W 9-1 |
|
| 3/18/2005 | at | San Jose State | * | L 10-8 |
|
| 3/19/2005 | at | San Jose State | * |
| PPD to 3/20, rain |
| 3/20/2005 | at | San Jose State | * | L 5-1 |
|
| 3/20/2005 | at | San Jose State | * | L 4-1 | makeup of 3/19 game |
| 3/22/2005 |
| Sam Houston State |
| W 16-2 |
|
| 3/25/2005 |
| Nevada | * | W 11-2 |
|
| 3/26/2005 |
| Nevada | * | W 14-6 | 600th win for Wayne Graham (Rice) |
| 3/27/2005 |
| Nevada | * | L 7-5 |
|
| 3/29/2005 | at | Houston |
| W 6-2 |
|
| 4/1/2005 | at | Fresno State | * | W 8-2 |
|
| 4/2/2005 | at | Fresno State | * | W 8-0 |
|
| 4/3/2005 | at | Fresno State | * | L 2-1 |
|
| 4/6/2005 | vs | Louisiana State |
| L 8-2 | Metairie, LA |
| 4/8/2005 | at | Louisiana Tech | * | L 3-2 |
|
| 4/9/2005 | at | Louisiana Tech | * | W 9-6 |
|
| 4/10/2005 | at | Louisiana Tech | * | W 11-4 |
|
| 4/12/2005 |
| Texas A&M |
| W 5-3 |
|
| 4/15/2005 | at | Hawaii | * | L 3-2 |
|
| 4/16/2005 | at | Hawaii | * | W 4-0 |
|
| 4/17/2005 | at | Hawaii | * | W 3-1 |
|
| 4/20/2005 |
| Texas |
| L 7-6 |
|
| 4/22/2005 |
| Louisiana Tech | * | W 12-6 |
|
| 4/23/2005 |
| Louisiana Tech | * | W 17-1 |
|
| 4/24/2005 |
| Louisiana Tech | * | W 6-2 |
|
| 4/26/2005 |
| Houston |
| W 10-9 |
|
| 4/29/2005 |
| Fresno State | * | W 6-4 |
|
| 4/29/2005 |
| Fresno State | * | L 8-7 |
|
| 4/30/2005 |
| Fresno State | * | W 10-2 |
|
| 5/11/2005 |
| Baylor |
| W 7-0 |
|
| 5/13/2005 | at | Nevada | * | W 9-3 |
|
| 5/14/2005 | at | Nevada | * | W 16-3 |
|
| 5/15/2005 | at | Nevada | * | W 12-3 |
|
| 5/17/2005 | at | Houston |
| L 3-2 |
|
| 5/20/2005 |
| Hawaii | * | L 7-4 |
|
| 5/21/2005 |
| Hawaii | * | W 7-6 | 12 innings |
| 5/22/2005 |
| Hawaii | * | W 14-11 |
|
| 5/27/2005 |
| San Jose State | * | W 5-3 |
|
| 5/28/2005 |
| San Jose State | * | W 4-2 |
|
| 5/29/2005 |
| San Jose State | * | W 4-1 |
|
| 6/3/2005 | vs | Northwestern State |
| W 7-3 | Baton Rouge Regional, Game 1 |
| 6/4/2005 | at | Louisiana State |
| W 9-7 | Baton Rouge Regional, Game 4 |
| 6/5/2005 | at | Louisiana State |
|
| PPD to 6/6, rain (Baton Rouge regional) |
| 6/6/2005 | at | Louisiana State |
| W 5-4 | Baton Rouge Regional, Game 6 |
| 6/11/2005 | at | Tulane |
| W 9-5 | #1 national seed Super Regional, Game 1 |
| 6/12/2005 | at | Tulane |
| L 7-0 | #1 national seed Super Regional, Game 2 |
| 6/13/2005 | at | Tulane |
| L 9-6 | #1 national seed Super Regional, Game 3 |