| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/23/2006 | * | #24 Southern Mississippi | 3 | at | #1 Rice | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #13 North Carolina State | 2 | at | #2 North Carolina | 3 | FINAL | Box Score | Recap | 14 innings (resumption of suspended game) |
| 4/23/2006 | * | #13 North Carolina State | 0 | at | #2 North Carolina | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #3 Nebraska | 6 | at | #7 Texas | 0 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #4 Cal State Fullerton | 8 | at | Pacific | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #9 Georgia Tech | 10 | at | #5 Florida State | 4 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | #9 Georgia Tech | 8 | at | #5 Florida State | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #8 South Carolina | 9 | at | Kentucky | 12 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #10 Arizona State | 10 | at | UCLA | 11 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | #11 Oregon State | 9 | at | California | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #12 Arkansas | 6 | at | #15 Mississippi State | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #26 Vanderbilt | 5 | at | #14 Alabama | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #16 Oklahoma | 8 | at | Texas Tech | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Wofford | 3 | at | #17 College of Charleston | 6 | FINAL | | Recap | |
| 4/23/2006 | * | #18 Virginia | 8 | at | #24 Miami, Florida | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | #19 Old Dominion | 3 | at | Delaware | 8 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | #19 Old Dominion | 11 | at | Delaware | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #20 Louisiana State | 8 | at | Mississippi | 11 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Radford | 8 | at | #21 Winthrop | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Rutgers | 12 | at | #22 Notre Dame | 14 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Stephen F. Austin | 3 | at | #23 Tulane | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Memphis | 7 | at | #27 Houston | 8 | FINAL | Box Score | Recap | 16 innings |
| 4/23/2006 | * | Bradley | 3 | at | #28 Wichita State | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #29 Troy | 11 | at | Arkansas State | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Maryland | 3 | at | #30 Wake Forest | 2 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/23/2006 | * | Albany | 7 | at | Maryland-Baltimore County | 8 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | Albany | 7 | at | Maryland-Baltimore County | 5 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | Albany | 11 | at | Maryland-Baltimore County | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| New York Tech | 12 | at | Maine | 13 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/23/2006 | * | Duquesne | 8 | at | Richmond | 11 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | Duquesne | 0 | at | Richmond | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | George Washington |
| at | Temple |
| Cancelled | | Recap | CCD, rain (makeup of 4/22 game) |
| 4/23/2006 | * | George Washington |
| at | Temple |
| Cancelled | | Recap | CCD, rain |
| 4/23/2006 | * | LaSalle | 1 | at | North Carolina-Charlotte | 11 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Massachusetts | 6 | at | St. Louis | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | St. Bonaventure |
| at | Rhode Island |
| Cancelled | | Recap | CCD, rain |
| 4/23/2006 | * | St. Joseph's | 1 | at | Fordham | 8 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Xavier | 5 | at | Dayton | 8 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/23/2006 | * | #13 North Carolina State | 2 | at | #2 North Carolina | 3 | FINAL | Box Score | Recap | 14 innings (resumption of suspended game) |
| 4/23/2006 | * | #13 North Carolina State | 0 | at | #2 North Carolina | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #9 Georgia Tech | 10 | at | #5 Florida State | 4 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | #9 Georgia Tech | 8 | at | #5 Florida State | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #18 Virginia | 8 | at | #24 Miami, Florida | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | Maryland | 3 | at | #30 Wake Forest | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Duke | 10 | at | Virginia Tech | 9 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/23/2006 | * | East Tennessee State | 8 | at | Jacksonville | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Florida Atlantic | 6 | at | Belmont | 5 | FINAL | Box Score | Recap | 13 innings |
| 4/23/2006 |
| Lipscomb | 5 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/23/2006 | * | Iowa | 17 | at | Illinois | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Michigan | 5 | at | Purdue | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Minnesota | 6 | at | Michigan State | 3 | FINAL | Box Score | Recap | 7 innings (rain) |
| 4/23/2006 | * | Ohio State | 8 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Penn State | 15 | at | Northwestern | 5 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/23/2006 | * | #3 Nebraska | 6 | at | #7 Texas | 0 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #16 Oklahoma | 8 | at | Texas Tech | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Kansas | 4 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Oklahoma State | 3 | at | Missouri | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Texas A&M | 8 | at | Baylor | 9 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/23/2006 | * | Rutgers | 12 | at | #22 Notre Dame | 14 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Connecticut |
| at | St. John's |
| Cancelled | | Recap | CCD, field conditions |
| 4/23/2006 | * | Georgetown | 5 | at | Cincinnati | 9 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Louisville | 5 | at | West Virginia | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | South Florida | 9 | at | Pittsburgh | 11 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Villanova | 11 | at | Seton Hall | 6 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | Villanova | 4 | at | Seton Hall | 5 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/23/2006 | * | Radford | 8 | at | #21 Winthrop | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Coastal Carolina | 4 | at | Liberty | 6 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | Coastal Carolina | 8 | at | Liberty | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | North Carolina-Asheville | 2 | at | High Point | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Virginia Military | 2 | at | Birmingham-Southern | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Lipscomb | 5 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/23/2006 | * | #4 Cal State Fullerton | 8 | at | Pacific | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Cal Poly | 7 | at | UC Riverside | 1 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | UC Santa Barbara | 4 | at | UC Irvine | 14 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Long Beach State | 2 | at | UC Davis | 1 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/23/2006 | * | #19 Old Dominion | 3 | at | Delaware | 8 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | #19 Old Dominion | 11 | at | Delaware | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Georgia State | 3 | at | North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | James Madison | 3 | at | Hofstra | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Virginia Commonwealth | 4 | at | George Mason | 3 | FINAL | Box Score | Recap | makeup of 4/22 game |
| 4/23/2006 | * | Virginia Commonwealth | 9 | at | George Mason | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | William and Mary | 1 | at | Northeastern | 9 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/23/2006 | * | #24 Southern Mississippi | 3 | at | #1 Rice | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Stephen F. Austin | 3 | at | #23 Tulane | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Memphis | 7 | at | #27 Houston | 8 | FINAL | Box Score | Recap | 16 innings |
| 4/23/2006 | * | Alabama-Birmingham | 16 | at | UCF | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Marshall | 5 | at | East Carolina | 3 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/23/2006 |
| IUPU-Fort Wayne | 4 | at | Western Kentucky | 13 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Maryland-Eastern Shore | 1 | at | Savannah State | 7 | FINAL | Box Score | | |
| 4/23/2006 |
| New York Tech | 12 | at | Maine | 13 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| North Carolina A&T | 4 | at | Longwood | 5 | FINAL | | Recap | makeup of 4/22 game |
| 4/23/2006 |
| North Carolina A&T | 2 | at | Longwood | 1 | FINAL | | Recap | |
| 4/23/2006 |
| North Dakota State | 3 | at | South Dakota State | 15 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Utah Valley State | 1 | at | Nevada | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Washington State | 5 | at | Northern Colorado | 2 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/23/2006 | * | Illinois-Chicago | 4 | at | Butler | 1 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Wisconsin-Milwaukee | 11 | at | Cleveland State | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Youngstown State | 2 | at | Wright State | 4 | FINAL | Box Score | Recap | moved from 4/21, impending weather |
| Ivy League |
| 4/23/2006 | * | Brown |
| at | Harvard |
| Postponed | | Recap | PPD to 4/24, rain |
| 4/23/2006 | * | Brown |
| at | Harvard |
| Postponed | | Recap | PPD to 4/24, rain |
| 4/23/2006 | * | Columbia | 7 | at | Cornell | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Columbia | 6 | at | Cornell | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Pennsylvania | 3 | at | Princeton | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Pennsylvania | 3 | at | Princeton | 2 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | Yale |
| at | Dartmouth |
| Postponed | | Recap | PPD, rain |
| 4/23/2006 | * | Yale |
| at | Dartmouth |
| Postponed | | Recap | PPD, rain |
| Metro Atlantic Athletic Conference |
| 4/23/2006 | * | Iona |
| at | Manhattan |
|
| | Recap | PPD to 4/24, rain (makeup of 4/22 game) |
| 4/23/2006 | * | Iona |
| at | Manhattan |
|
| | Recap | CCD, rain |
| 4/23/2006 | * | LeMoyne |
| at | St. Peter's |
|
| | | CCD, field conditions (makeup of 4/22 game) |
| 4/23/2006 | * | LeMoyne |
| at | St. Peter's |
|
| | | CCD, field conditions |
| 4/23/2006 | * | Marist |
| at | Fairfield |
| Postponed | | Recap | PPD to 4/24, rain (makeup of 4/22 game) |
| 4/23/2006 | * | Marist |
| at | Fairfield |
| Cancelled | | Recap | CCD, rain |
| 4/23/2006 | * | Niagara | 6 | at | Rider | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Siena | 8 | at | Canisius | 13 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/23/2006 | * | Ball State | 7 | at | Eastern Michigan | 0 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | Ball State | 4 | at | Eastern Michigan | 5 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | Bowling Green State | 2 | at | Akron | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Central Michigan | 5 | at | Northern Illinois | 12 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Miami, Ohio | 3 | at | Kent State | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Western Michigan | 4 | at | Toledo | 8 | FINAL | Box Score | Recap | |
| Mid Continent Conference |
| 4/23/2006 | * | Oakland | 7 | at | Valparaiso | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | Oakland | 1 | at | Valparaiso | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Oral Roberts | 10 | at | Centenary | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Oral Roberts | 11 | at | Centenary | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Western Illinois | 20 | at | Chicago State | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Western Illinois | 7 | at | Chicago State | 2 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/23/2006 | * | Bethune-Cookman |
| at | Coppin State |
|
| | | CCD, field conditions |
| 4/23/2006 | * | Norfolk State | 3 | at | Delaware State | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Maryland-Eastern Shore | 1 | at | Savannah State | 7 | FINAL | Box Score | | |
| 4/23/2006 |
| North Carolina A&T | 4 | at | Longwood | 5 | FINAL | | Recap | makeup of 4/22 game |
| 4/23/2006 |
| North Carolina A&T | 2 | at | Longwood | 1 | FINAL | | Recap | |
| Missouri Valley Conference |
| 4/23/2006 | * | Bradley | 3 | at | #28 Wichita State | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Evansville | 7 | at | Creighton | 1 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Northern Iowa | 7 | at | Indiana State | 17 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Southern Illinois | 9 | at | Missouri State | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Illinois Tech | 6 | at | Illinois State | 5 | FINAL | | Recap | |
| Mountain West Conference |
| 4/23/2006 | * | San Diego State | 16 | at | Nevada-Las Vegas | 8 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Utah | 8 | at | New Mexico | 9 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/23/2006 | * | Fairleigh Dickinson | 4 | at | Monmouth | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Fairleigh Dickinson | 1 | at | Monmouth | 9 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Long Island |
| at | Quinnipiac |
| Cancelled | | Recap | CCD, rain |
| 4/23/2006 | * | Mount St. Mary's |
| at | Sacred Heart |
|
| | Recap | PPD to 4/24, rain (makeup of 4/22 game) |
| 4/23/2006 | * | Mount St. Mary's |
| at | Sacred Heart |
|
| | Recap | CCD, rain |
| 4/23/2006 | * | Wagner |
| at | Central Connecticut State |
| Postponed | | Recap | PPD to 4/24, rain |
| Ohio Valley Conference |
| 4/23/2006 | * | Austin Peay State | 7 | at | Southeast Missouri State | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Eastern Illinois | 6 | at | Samford | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Eastern Kentucky | 5 | at | Jacksonville State | 10 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Morehead State | 2 | at | Murray State | 14 | FINAL | | Recap | |
| 4/23/2006 | * | Tennessee Tech | 5 | at | Tennessee-Martin | 6 | FINAL | Box Score | Recap | 10 innings |
| Pac 10 Conference |
| 4/23/2006 | * | #10 Arizona State | 10 | at | UCLA | 11 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | #11 Oregon State | 9 | at | California | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Stanford | 3 | at | Arizona | 12 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Washington | 7 | at | Southern California | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Washington State | 5 | at | Northern Colorado | 2 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/23/2006 | * | Army | 4 | vs | Navy | 0 | FINAL | Box Score | Recap | Baltimore, MD |
| 4/23/2006 | * | Army | 0 | vs | Navy | 2 | FINAL | Box Score | Recap | Baltimore, MD |
| 4/23/2006 | * | Holy Cross | 6 | at | Bucknell | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Holy Cross | 0 | at | Bucknell | 9 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Lafayette | 0 | at | Lehigh | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Lafayette | 2 | at | Lehigh | 3 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/23/2006 | * | #8 South Carolina | 9 | at | Kentucky | 12 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #12 Arkansas | 6 | at | #15 Mississippi State | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #26 Vanderbilt | 5 | at | #14 Alabama | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | #20 Louisiana State | 8 | at | Mississippi | 11 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Auburn | 5 | at | Florida | 4 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Tennessee | 6 | at | Georgia | 4 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/23/2006 | * | Wofford | 3 | at | #17 College of Charleston | 6 | FINAL | | Recap | |
| 4/23/2006 | * | Elon | 10 | at | Davidson | 3 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | Elon | 8 | at | Davidson | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Furman | 2 | at | Appalachian State | 7 | FINAL | Box Score | Recap | makeup of 4/21 game |
| 4/23/2006 | * | Furman | 17 | at | Appalachian State | 11 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | North Carolina-Greensboro | 5 | at | Georgia Southern | 12 | FINAL | Box Score | Recap | resumption of suspended game |
| 4/23/2006 | * | North Carolina-Greensboro | 8 | at | Georgia Southern | 9 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Western Carolina | 8 | at | The Citadel | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Western Carolina | 3 | at | The Citadel | 4 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/23/2006 |
| Stephen F. Austin | 3 | at | #23 Tulane | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Louisiana-Monroe | 10 | at | Lamar | 5 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | McNeese State | 7 | at | Nicholls State | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Northwestern State | 2 | at | Southeastern Louisiana | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Texas State | 3 | at | Sam Houston State | 7 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Texas-San Antonio | 3 | at | Texas-Arlington | 5 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/23/2006 | * | Jackson State | 7 | at | Alabama A&M | 6 | FINAL | Box Score | | |
| 4/23/2006 | * | Jackson State | 15 | at | Alabama A&M | 3 | FINAL | Box Score | | |
| 4/23/2006 | * | Mississippi Valley State | 20 | at | Alabama State | 9 | FINAL | | Recap | |
| 4/23/2006 | * | Mississippi Valley State | 3 | at | Alabama State | 4 | FINAL | | Recap | |
| 4/23/2006 | * | Southern | 7 | at | Grambling State | 6 |
| | | |
| 4/23/2006 | * | Texas Southern | 6 | at | Arkansas-Pine Bluff | 4 | FINAL | | | |
| Sun Belt Conference |
| 4/23/2006 | * | #29 Troy | 11 | at | Arkansas State | 6 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Arkansas-Little Rock | 3 | at | New Orleans | 8 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Louisiana-Lafayette | 14 | at | Florida International | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Middle Tennessee State | 10 | at | South Alabama | 20 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| IUPU-Fort Wayne | 4 | at | Western Kentucky | 13 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/23/2006 | * | San Diego | 4 | at | Pepperdine | 5 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2006 | * | San Francisco | 8 | at | Gonzaga | 9 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Santa Clara | 4 | at | Loyola Marymount | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | St. Mary's | 6 | at | Portland | 5 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/23/2006 | * | Fresno State | 4 | at | San Jose State | 0 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | Louisiana Tech | 1 | at | Cal State Sacramento | 2 | FINAL | Box Score | Recap | |
| 4/23/2006 | * | New Mexico State | 5 | at | Hawaii | 3 | FINAL | Box Score | Recap | |
| 4/23/2006 |
| Utah Valley State | 1 | at | Nevada | 5 | FINAL | Box Score | Recap | |