| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
|---|
| National Collegiate Baseball Writers Poll |
|---|
| 5/21/2006 | * | Cal Poly | 0 | at | #3 Cal State Fullerton | 1 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #4 Texas | 5 | at | Missouri | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #9 Oregon State | 13 | at | Washington State | 3 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #18 Oklahoma | 6 | at | #11 Nebraska | 2 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #12 Arizona State | 4 | at | Arizona | 5 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #16 Winthrop | 3 | at | Virginia Military | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Texas Tech | 3 | at | #24 Oklahoma State | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 |
| Southern California | 8 | at | #25 Wichita State | 10 | FINAL | Box Score | Recap |
|
| America East Conference |
|---|
| 5/21/2006 | * | Albany | 2 | at | Binghamton | 4 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Maine | 11 | at | Vermont | 3 | FINAL |
|
| makeup of 5/20 game |
| 5/21/2006 | * | Maryland-Baltimore County | 4 | at | Stony Brook | 14 | FINAL | Box Score | Recap |
|
| Big 10 Conference |
|---|
| 5/21/2006 | * | Illinois | 10 | at | Michigan State | 2 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Indiana | 4 | at | Minnesota | 6 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Iowa | 1 | at | Michigan | 3 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Northwestern | 14 | at | Purdue | 9 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Penn State | 2 | at | Ohio State | 12 | FINAL | Box Score | Recap |
|
| Big 12 Conference |
|---|
| 5/21/2006 | * | #4 Texas | 5 | at | Missouri | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #18 Oklahoma | 6 | at | #11 Nebraska | 2 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Texas Tech | 3 | at | #24 Oklahoma State | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Baylor | 2 | at | Kansas State | 3 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Texas A&M | 6 | at | Kansas | 11 | FINAL | Box Score | Recap |
|
| Big South Conference |
|---|
| 5/21/2006 | * | #16 Winthrop | 3 | at | Virginia Military | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | High Point | 13 | at | Liberty | 8 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | North Carolina-Asheville | 1 | at | Coastal Carolina | 6 | FINAL | Box Score | Recap | resumption of suspended game |
| 5/21/2006 | * | North Carolina-Asheville | 5 | at | Coastal Carolina | 13 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Radford | 4 | at | Birmingham-Southern | 14 | FINAL | Box Score | Recap |
|
| Big West Conference |
|---|
| 5/21/2006 | * | Cal Poly | 0 | at | #3 Cal State Fullerton | 1 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Long Beach State | 5 | at | UC Riverside | 2 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | UC Irvine | 3 | at | Cal State Northridge | 1 | FINAL | Box Score | Recap |
|
| 5/21/2006 |
| UC Davis | 5 | at | UC Santa Barbara | 20 | FINAL | Box Score | Recap |
|
| 5/21/2006 |
| Washington |
| at | Pacific |
| Cancelled |
| Recap | CCD, rain |
| Colonial Athletic Association |
|---|
| 5/21/2006 | * | William and Mary | 8 | at | Georgia State | 4 | FINAL | Box Score | Recap |
|
| Division I Independents |
|---|
| 5/21/2006 |
| IUPU-Fort Wayne | 12 | vs | Utah Valley State | 4 | FINAL | Box Score | Recap | Independent Invitational, Sioux Falls, SD |
| 5/21/2006 |
| New York Tech | 2 | at | South Dakota State | 5 | FINAL |
| Recap | Independent Invitational, Sioux Falls, SD |
| 5/21/2006 |
| North Dakota State | 1 | vs | Northern Colorado | 6 | FINAL | Box Score | Recap | Independent Invitational, Sioux Falls, SD |
| Mid Continent Conference |
|---|
| 5/21/2006 | * | Oakland | 1 | at | Oral Roberts | 21 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Oakland | 0 | at | Oral Roberts | 7 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Southern Utah | 4 | at | Chicago State | 11 | FINAL |
|
|
|
| 5/21/2006 | * | Southern Utah | 5 | at | Chicago State | 6 | FINAL | Box Score |
|
|
| Mid-Eastern Athletic Conference |
|---|
| 5/21/2006 | MEAC-10 | Maryland-Eastern Shore | 0 | vs | Bethune-Cookman | 14 | FINAL | Box Score | Recap | MEAC Tournament, Game 10, Norfolk, VA |
| Missouri Valley Conference |
|---|
| 5/21/2006 |
| Southern California | 8 | at | #25 Wichita State | 10 | FINAL | Box Score | Recap |
|
| Northeast Conference |
|---|
| 5/21/2006 | * | Monmouth | 5 | at | Wagner | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/21/2006 | * | St. Francis | 1 | at | Long Island | 6 | FINAL | Box Score |
|
|
| Pac 10 Conference |
|---|
| 5/21/2006 | * | #9 Oregon State | 13 | at | Washington State | 3 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | #12 Arizona State | 4 | at | Arizona | 5 | FINAL | Box Score | Recap |
|
| 5/21/2006 |
| Southern California | 8 | at | #25 Wichita State | 10 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Stanford | 7 | at | UCLA | 8 | FINAL | Box Score | Recap |
|
| 5/21/2006 |
| Washington |
| at | Pacific |
| Cancelled |
| Recap | CCD, rain |
| Southwestern Athletic Conference |
|---|
| 5/21/2006 | SWAC-10 | Prairie View A&M | 3 | vs | Alcorn State | 2 | FINAL | Box Score | Recap | SWAC Tournament, Game 10, Pearl, MS |
| West Coast Conference |
|---|
| 5/21/2006 | * | Loyola Marymount | 13 | at | Portland | 9 | FINAL | Box Score | Recap |
|
| Western Athletic Conference |
|---|
| 5/21/2006 | * | Fresno State | 7 | at | Cal State Sacramento | 4 | FINAL | Box Score | Recap |
|
| 5/21/2006 | * | Hawaii | 3 | at | San Jose State | 1 | FINAL | Box Score | Recap |
|