| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 3/5/2006 | vs | Seton Hall |
| L 6-4 | Bradenton, FL |
| 3/6/2006 | vs | Maine |
| L 7-1 | Palm Beach, FL |
| 3/7/2006 | vs | Maine |
| L 14-10 | Palm Beach, FL |
| 3/9/2006 | vs | Monmouth |
| W 5-4 | Boca Raton, FL |
| 3/10/2006 | vs | Monmouth |
| W 6-1 | Boca Raton, FL |
| 3/11/2006 | vs | Monmouth |
| L 5-4 | Boca Raton, FL (11 innings) |
| 3/11/2006 | vs | Iona |
| W 15-13 | Boca Raton, FL |
| 3/12/2006 | vs | Long Island |
| W 17-2 | Papa John Baseball Classic, West Palm Beach, FL |
| 3/21/2006 | at | West Virginia |
|
| CCD, inclement weather |
| 3/22/2006 | at | West Virginia |
| L 18-4 |
|
| 3/24/2006 | at | Duquesne | * | L 8-7 |
|
| 3/25/2006 | at | Duquesne | * | W 4-1 |
|
| 3/26/2006 | at | Duquesne | * | W 15-4 |
|
| 3/31/2006 | at | Dayton | * | W 7-2 |
|
| 4/1/2006 | at | Dayton | * | L 5-4 |
|
| 4/2/2006 | at | Dayton | * | L 7-4 |
|
| 4/4/2006 | at | Canisius |
|
| CCD, inclement weather |
| 4/5/2006 | at | LeMoyne |
|
| PPD to 5/15, inclement weather |
| 4/5/2006 | at | LeMoyne |
|
| PPD to 5/15, inclement weather |
| 4/7/2006 |
| North Carolina-Charlotte | * |
| PPD to 4/9, rain |
| 4/8/2006 |
| North Carolina-Charlotte | * | W 7-6 |
|
| 4/9/2006 |
| North Carolina-Charlotte | * | W 2-1 | makeup of 4/7 game |
| 4/9/2006 |
| North Carolina-Charlotte | * | L 5-1 |
|
| 4/11/2006 |
| Binghamton |
| W 7-6 |
|
| 4/11/2006 |
| Binghamton |
| L 3-1 |
|
| 4/13/2006 |
| George Washington | * | L 10-2 |
|
| 4/14/2006 |
| George Washington | * |
| PPD to 4/15, rain |
| 4/15/2006 |
| George Washington | * | W 5-4 | makeup of 4/14 game |
| 4/15/2006 |
| George Washington | * | W 5-3 |
|
| 4/18/2006 | at | Niagara |
| W 8-1 |
|
| 4/18/2006 | at | Niagara |
| L 9-2 |
|
| 4/19/2006 |
| Buffalo |
| L 8-4 |
|
| 4/19/2006 |
| Buffalo |
| L 8-5 |
|
| 4/21/2006 | at | Rhode Island | * | W 5-4 |
|
| 4/22/2006 | at | Rhode Island | * | W 6-3 |
|
| 4/23/2006 | at | Rhode Island | * |
| CCD, rain |
| 4/25/2006 | vs | Niagara |
| W 7-5 | Big Four Classic, Buffalo, NY |
| 4/26/2006 | vs | Canisius |
| L 12-4 | Big Four Classic, Buffalo, NY |
| 4/28/2006 |
| Xavier | * | W 6-3 |
|
| 4/29/2006 |
| Xavier | * | W 9-2 |
|
| 4/30/2006 |
| Xavier | * | W 14-4 |
|
| 5/2/2006 |
| Niagara |
| L 12-8 |
|
| 5/3/2006 |
| Canisius |
| W 7-5 |
|
| 5/5/2006 | at | Massachusetts | * | W 7-3 |
|
| 5/6/2006 | at | Massachusetts | * | W 10-2 |
|
| 5/7/2006 | at | Massachusetts | * | L 9-6 |
|
| 5/12/2006 | at | Temple | * | W 12-2 |
|
| 5/13/2006 | at | Temple | * | L 4-2 |
|
| 5/14/2006 | at | Temple | * | W 6-5 |
|
| 5/15/2006 | at | LeMoyne |
|
| CCD, rain (makeup of 4/5 game) |
| 5/18/2006 |
| Richmond | * | W 5-3 |
|
| 5/19/2006 |
| Richmond | * | W 8-2 |
|
| 5/20/2006 |
| Richmond | * | L 8-7 |
|
| 5/25/2006 | vs | Dayton | A10-05 | W 4-3 | Atlantic 10 Tournament, Game 5, New York, NY |
| 5/26/2006 | vs | St. Louis | A10-07 | L 10-5 | Atlantic 10 Tournament, Game 7, New York, NY |
| 5/26/2006 | vs | George Washington | A10-09 |
| suspended to 5/27, rain (3-1 SBU, Bottom 2) (Atlantic 10 Tournament) |
| 5/27/2006 | vs | St. Louis | A10-10 | W 3-2 | Atlantic 10 Tournament, Game 10, New York, NY |
| 5/27/2006 | vs | George Washington | A10-09 | W 9-2 | Atlantic 10 Tournament, Game 9, New York, NY |
| 5/28/2006 | vs | St. Louis | A10-11 | L 7-0 | Atlantic 10 Tournament, Game 11, New York, NY (if necessary) |