| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/24/2006 | at | Florida Atlantic |
|
| PPD to 2/25, rain |
| 2/25/2006 | at | Florida Atlantic |
| L 1-0 | makeup of 2/24 game |
| 2/25/2006 | at | Florida Atlantic |
| W 2-0 |
|
| 2/26/2006 | at | Florida Atlantic |
| W 9-1 |
|
| 3/3/2006 | vs | New Orleans |
| W 6-3 | Lamar Classic, Beaumont, TX |
| 3/4/2006 | at | Lamar |
| L 4-0 | Lamar Classic, Beaumont, TX |
| 3/5/2006 | vs | Iona |
| W 6-0 | Lamar Classic, Beaumont, TX |
| 3/6/2006 | vs | Mount St. Mary's |
| W 17-0 | Bradenton, FL |
| 3/7/2006 | vs | Jacksonville |
| L 7-6 | Clearwater, FL (10 innings) |
| 3/8/2006 | vs | Yale |
| L 8-7 | Bradenton, FL |
| 3/9/2006 | vs | Toledo |
| L 2-0 | Clearwater, FL |
| 3/10/2006 | vs | Duquesne |
| W 11-1 | Bradenton, FL |
| 3/11/2006 | vs | Eastern Kentucky |
| W 5-4 | Florida All-Star Baseball Challenge, Bradenton, FL |
| 3/14/2006 | at | Northeastern |
|
| CCD, rain |
| 3/15/2006 | at | Sacred Heart |
| W 20-1 |
|
| 3/17/2006 | at | South Florida | * | L 4-3 |
|
| 3/18/2006 | at | South Florida | * | W 7-6 | 11 innings |
| 3/19/2006 | at | South Florida | * | L 4-3 |
|
| 3/22/2006 | at | Quinnipiac |
| L 4-3 |
|
| 3/24/2006 |
| Cincinnati | * | W 13-1 |
|
| 3/25/2006 |
| Cincinnati | * | W 6-5 |
|
| 3/26/2006 |
| Cincinnati | * | W 3-2 |
|
| 3/28/2006 | at | Fairfield |
| W 5-3 |
|
| 3/29/2006 |
| Yale |
| W 8-5 |
|
| 3/31/2006 | at | Louisville | * | W 10-2 |
|
| 4/1/2006 | at | Louisville | * | L 3-2 | 12 innings |
| 4/2/2006 | at | Louisville | * | W 11-10 |
|
| 4/4/2006 |
| Hartford |
| W 4-2 | 5 innings (snow) |
| 4/5/2006 | at | Marist |
| W 19-6 |
|
| 4/7/2006 |
| Villanova | * |
| PPD to 4/8, rain |
| 4/8/2006 |
| Villanova | * |
| CCD, rain |
| 4/9/2006 |
| Villanova | * | W 1-0 |
|
| 4/9/2006 |
| Villanova | * | W 7-3 | makeup of 4/7 game |
| 4/10/2006 | at | Boston College |
| L 6-5 |
|
| 4/11/2006 |
| Massachusetts |
| W 7-1 |
|
| 4/13/2006 | at | West Virginia | * | W 6-3 |
|
| 4/14/2006 | at | West Virginia | * |
| suspended to 4/15, rain (3-0 Uconn, Top 4) |
| 4/15/2006 | at | West Virginia | * | W 7-5 | resumption of suspended game |
| 4/15/2006 | at | West Virginia | * | W 13-8 |
|
| 4/17/2006 | at | Siena |
| L 9-8 |
|
| 4/18/2006 | at | Hartford |
| L 3-1 |
|
| 4/21/2006 | at | St. John's | * | W 6-3 |
|
| 4/22/2006 | at | St. John's | * | W 4-2 |
|
| 4/23/2006 | at | St. John's | * |
| CCD, field conditions |
| 4/25/2006 |
| Fairfield |
| L 5-4 |
|
| 4/26/2006 |
| Hartford |
| W 15-3 |
|
| 4/27/2006 |
| Central Connecticut State |
| W 14-13 |
|
| 4/29/2006 |
| Notre Dame | * | L 7-6 |
|
| 4/29/2006 |
| Notre Dame | * | L 7-3 |
|
| 4/30/2006 |
| Notre Dame | * | T 1-1 | 13 innings (travel curfew) |
| 5/8/2006 | at | Hofstra |
| W 9-4 |
|
| 5/9/2006 | at | Massachusetts |
| W 12-1 |
|
| 5/10/2006 |
| Northeastern |
| W 7-1 |
|
| 5/12/2006 | at | Pittsburgh | * | W 5-4 |
|
| 5/13/2006 | at | Pittsburgh | * | W 6-4 |
|
| 5/14/2006 | at | Pittsburgh | * | L 11-9 |
|
| 5/15/2006 | at | Rhode Island |
|
| PPD to 5/17, rain |
| 5/16/2006 |
| Vermont |
|
| CCD, rain |
| 5/17/2006 |
| Rhode Island |
| W 9-5 |
|
| 5/17/2006 |
| Rhode Island |
| W 3-2 | makeup of 5/15 game (URI bats as home team) |
| 5/18/2006 |
| Rutgers | * | W 11-7 |
|
| 5/19/2006 |
| Rutgers | * | W 7-4 |
|
| 5/20/2006 |
| Rutgers | * | W 10-1 |
|
| 5/23/2006 | vs | Cincinnati | BIGEAST-02 | W 6-2 | Big East Tournament, Game 2, Clearwater, FL |
| 5/24/2006 | vs | Louisville | BIGEAST-07 | L 12-10 | Big East Tournament, Game 7, Clearwater, FL |
| 5/25/2006 | vs | Rutgers | BIGEAST-09 | L 9-5 | Big East Tournament, Game 9, Clearwater, FL |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/23/2006 | vs | Indiana State |
| W 3-0 | Service Academies Spring Classic, Millington, TN |
| 2/24/2006 | vs | Air Force |
| W 8-2 | Service Academies Spring Classic, Millington, TN |
| 2/25/2006 | vs | Memphis |
| L 7-6 | Service Academies Spring Classic, Millington, TN (10 innings) |
| 2/26/2006 | vs | Oklahoma |
| L 4-3 | Service Academies Spring Classic, Millington, TN |
| 3/3/2006 | vs | Nebraska |
| L 11-1 | Dairy Queen Classic, Minneapolis, MN |
| 3/4/2006 | at | Minnesota |
| L 8-0 | Dairy Queen Classic, Minneapolis, MN |
| 3/5/2006 | vs | Arizona |
| L 2-0 | Dairy Queen Classic, Minneapolis, MN (10 innings) |
| 3/10/2006 | vs | Texas A&M |
| W 5-4 | Baseball Express Collegiate Baseball Classic, San Antonio, TX |
| 3/11/2006 | vs | Iowa |
| W 16-2 | Baseball Express Collegiate Baseball Classic, San Antonio, TX |
| 3/12/2006 | vs | Illinois |
| W 4-2 | Baseball Express Collegiate Baseball Classic, San Antonio, TX |
| 3/13/2006 | vs | Iowa |
| W 6-2 | Baseball Express Collegiate Baseball Classic, San Antonio, TX |
| 3/16/2006 | vs | Iowa |
| W 7-5 | Irish Classic, San Antonio, TX |
| 3/17/2006 | vs | Southern Illinois |
| W 12-2 | Irish Classic, San Antonio, TX |
| 3/17/2006 | vs | Iowa |
| L 10-8 | Irish Classic, San Antonio, TX |
| 3/18/2006 | vs | Southern Illinois |
| W 4-0 | Irish Classic, San Antonio, TX |
| 3/21/2006 |
| Wright State |
| L 4-2 |
|
| 3/22/2006 |
| Central Michigan |
| W 11-9 |
|
| 3/25/2006 | at | Georgetown | * | L 8-3 |
|
| 3/25/2006 | at | Georgetown | * | W 12-2 |
|
| 3/26/2006 | at | Georgetown | * | W 6-3 |
|
| 3/28/2006 |
| Valparaiso |
| W 12-0 |
|
| 3/29/2006 |
| Western Michigan |
| W 2-0 |
|
| 3/31/2006 |
| Pittsburgh | * | W 6-1 |
|
| 4/1/2006 |
| Pittsburgh | * | W 4-3 |
|
| 4/2/2006 |
| Pittsburgh | * | W 9-8 |
|
| 4/4/2006 |
| Chicago State |
| W 6-4 |
|
| 4/5/2006 |
| Ball State |
| W 6-4 |
|
| 4/7/2006 | at | South Florida | * | W 9-6 |
|
| 4/8/2006 | at | South Florida | * | W 10-4 |
|
| 4/9/2006 | at | South Florida | * | W 10-1 |
|
| 4/11/2006 |
| Oakland |
| W 15-1 |
|
| 4/12/2006 |
| Manchester |
| W 8-2 |
|
| 4/13/2006 |
| St. John's | * | W 9-2 |
|
| 4/13/2006 |
| St. John's | * | W 13-7 |
|
| 4/15/2006 |
| St. John's | * | W 7-5 |
|
| 4/18/2006 |
| Toledo |
| W 8-2 |
|
| 4/19/2006 |
| IUPU-Fort Wayne |
| W 4-3 | 10 innings |
| 4/21/2006 |
| Rutgers | * | W 11-5 |
|
| 4/22/2006 |
| Rutgers | * | W 15-3 |
|
| 4/23/2006 |
| Rutgers | * | W 14-12 |
|
| 4/25/2006 |
| Purdue |
| W 2-1 |
|
| 4/26/2006 |
| Bowling Green State |
| L 11-8 | Snaps Notre Dame's 23-game winning streak |
| 4/29/2006 | at | Connecticut | * | W 7-6 |
|
| 4/29/2006 | at | Connecticut | * | W 7-3 |
|
| 4/30/2006 | at | Connecticut | * | T 1-1 | 13 innings (travel curfew) |
| 5/2/2006 |
| Cleveland State |
| W 12-1 |
|
| 5/5/2006 |
| Louisville | * | W 11-3 |
|
| 5/6/2006 |
| Louisville | * | L 5-4 |
|
| 5/7/2006 |
| Louisville | * | L 9-6 |
|
| 5/13/2006 | at | Seton Hall | * | L 7-6 |
|
| 5/13/2006 | at | Seton Hall | * | W 14-12 |
|
| 5/14/2006 | at | Seton Hall | * | L 2-1 |
|
| 5/16/2006 | vs | Michigan |
| L 3-1 | Comstock Park, MI |
| 5/18/2006 | at | Villanova | * | W 3-1 |
|
| 5/19/2006 | at | Villanova | * | W 6-2 |
|
| 5/20/2006 | at | Villanova | * | W 12-1 |
|
| 5/23/2006 | vs | South Florida | BIGEAST-04 | W 3-1 | Big East Tournament, Game 4, Clearwater, FL |
| 5/24/2006 | vs | West Virginia | BIGEAST-08 | W 12-4 | Big East Tournament, Game 8, Clearwater, FL |
| 5/26/2006 | vs | St. John's | BIGEAST-12 | L 10-1 | Big East Tournament, Game 12, Clearwater, FL |
| 5/26/2006 | vs | St. John's | BIGEAST-14 | W 5-3 | Big East Tournament, Game 14, Clearwater, FL |
| 5/27/2006 | vs | Louisville | BIGEAST-15 | W 7-0 | Big East Tournament, Championship Game, Clearwater, FL (ESPNU) |
| 6/2/2006 | vs | College of Charleston |
| L 5-4 | 16 innings (Lexington Regional, Game 1) |
| 6/3/2006 | vs | Kentucky |
| L 10-4 | Lexington Regional, Game 3 |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/17/2006 | vs | George Mason |
| L 9-2 | IMICHotels.com INN-vitational, Conway, SC |
| 2/17/2006 | at | Coastal Carolina |
| W 11-5 | IMICHotels.com INN-vitational, Conway, SC |
| 2/18/2006 | at | Coastal Carolina |
| W 6-0 | IMICHotels.com INN-vitational, Conway, SC |
| 2/19/2006 | vs | George Mason |
| L 3-1 | IMICHotels.com INN-vitational, Conway, SC (11 innings) |
| 2/24/2006 | at | Vanderbilt |
| L 2-1 | Game ended on balk during intentional walk (Music City Challenge, Nashville, TN (12 innings)) |
| 2/25/2006 | at | Belmont |
| W 14-7 | Music City Challenge, Nashville, TN |
| 2/26/2006 | at | Lipscomb |
| L 4-0 | Music City Challenge, Nashville, TN |
| 3/4/2006 | vs | Boston College |
| L 6-5 | Winter Park, FL (10 innings) |
| 3/5/2006 | vs | Boston College |
| L 10-5 | Winter Park, FL |
| 3/6/2006 | at | Rollins |
| W 4-0 |
|
| 3/7/2006 | vs | Sacred Heart |
| W 16-6 | Winter Park, FL |
| 3/8/2006 | at | Bethune-Cookman |
| L 6-0 |
|
| 3/9/2006 | vs | St. Joseph's |
| W 9-3 | Winter Park, FL |
| 3/11/2006 | vs | Sacred Heart |
| W 10-5 | Winter Park, FL |
| 3/11/2006 | vs | St. Joseph's |
| W 14-2 | Winter Park, FL |
| 3/14/2006 | at | Marshall |
|
| CCD, field conditions |
| 3/15/2006 |
| Duquesne |
|
| CCD, inclement weather |
| 3/17/2006 | at | Seton Hall | * | W 8-3 |
|
| 3/18/2006 | at | Seton Hall | * | L 2-1 |
|
| 3/19/2006 | at | Seton Hall | * | W 8-1 |
|
| 3/21/2006 |
| Cleveland State |
|
| PPD to 5/3, inclement weather |
| 3/22/2006 |
| Duquesne |
| W 18-8 | makeup of 3/15 game |
| 3/24/2006 | at | West Virginia | * | L 8-4 |
|
| 3/25/2006 | at | West Virginia | * | L 6-2 |
|
| 3/26/2006 | at | West Virginia | * | L 13-4 |
|
| 3/29/2006 |
| Kent State |
| L 14-4 |
|
| 3/31/2006 | at | Notre Dame | * | L 6-1 |
|
| 4/1/2006 | at | Notre Dame | * | L 4-3 |
|
| 4/2/2006 | at | Notre Dame | * | L 9-8 |
|
| 4/5/2006 | vs | Penn State |
| L 7-4 | Altoona, PA (11 innings) |
| 4/7/2006 |
| St. John's | * |
| suspended to 4/8, rain (2-1 SJU, Top 5) |
| 4/8/2006 |
| St. John's | * | L 6-2 | resumption of suspended game |
| 4/8/2006 |
| St. John's | * | W 3-2 |
|
| 4/9/2006 |
| St. John's | * | L 12-5 |
|
| 4/13/2006 | at | Villanova | * | W 9-5 |
|
| 4/13/2006 | at | Villanova | * | L 6-3 |
|
| 4/15/2006 | at | Villanova | * | L 6-3 |
|
| 4/18/2006 | at | Ohio |
| W 15-1 |
|
| 4/19/2006 |
| Akron |
| W 10-6 |
|
| 4/21/2006 |
| South Florida | * |
| PPD to 4/23, rain |
| 4/22/2006 |
| South Florida | * | W 7-1 | makeup of 4/21 game |
| 4/22/2006 |
| South Florida | * | L 5-3 |
|
| 4/23/2006 |
| South Florida | * | W 11-9 |
|
| 5/2/2006 | at | Kent State |
| L 17-14 |
|
| 5/3/2006 | at | Cleveland State |
| W 11-8 | makeup of 3/21 game |
| 5/6/2006 | at | Rutgers | * | W 12-11 |
|
| 5/6/2006 | at | Rutgers | * | L 15-9 |
|
| 5/7/2006 | at | Rutgers | * | L 10-5 |
|
| 5/9/2006 | at | Akron |
| L 15-11 |
|
| 5/10/2006 | vs | Duquesne |
| L 8-7 | Washington, PA |
| 5/12/2006 |
| Connecticut | * | L 5-4 |
|
| 5/13/2006 |
| Connecticut | * | L 6-4 |
|
| 5/14/2006 |
| Connecticut | * | W 11-9 |
|
| 5/16/2006 |
| Marshall |
|
| CCD, inclement weather |
| 5/17/2006 | at | Ohio State |
| W 7-3 | 6 innings (rain) |
| 5/18/2006 |
| Georgetown | * | W 14-0 |
|
| 5/19/2006 |
| Georgetown | * | W 3-2 | 10 innings |
| 5/20/2006 |
| Georgetown | * | L 8-7 |
|