| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/10/2006 |
| Campbell |
| W 9-0 | Springmaid Beach Resort Tournament, Conway, SC |
| 2/11/2006 |
| Virginia |
|
| CCD, rain (Springmaid Beach Resort Tournament, Conway, SC) |
| 2/12/2006 |
| Virginia |
| L 8-3 | Springmaid Beach Resort Tournament, Conway, SC |
| 2/17/2006 |
| Pittsburgh |
| L 11-5 | IMICHotels.com INN-vitational, Conway, SC |
| 2/18/2006 |
| George Mason |
| L 5-3 | IMICHotels.com INN-vitational, Conway, SC |
| 2/18/2006 |
| Pittsburgh |
| L 6-0 | IMICHotels.com INN-vitational, Conway, SC |
| 2/19/2006 |
| George Mason |
| W 22-6 | IMICHotels.com INN-vitational, Conway, SC |
| 2/21/2006 | at | North Carolina |
| L 15-0 |
|
| 2/24/2006 |
| Virginia Commonwealth |
| W 4-3 | Baseball at the Beach, Myrtle Beach, SC (10 innings) |
| 2/25/2006 |
| Tennessee |
|
| PPD to 2/26, rain (Baseball at the Beach, Myrtle Beach, SC) |
| 2/26/2006 |
| Georgia Tech |
|
| CCD, rain (Baseball at the Beach, Myrtle Beach, SC) |
| 2/26/2006 |
| Tennessee |
| L 10-6 | Baseball at the Beach, Myrtle Beach, SC |
| 3/1/2006 |
| Furman |
| L 9-6 |
|
| 3/3/2006 |
| Furman |
| L 7-2 | Coastal Carolina Tournament, Conway, SC |
| 3/4/2006 |
| West Virginia |
| L 10-3 | Coastal Carolina Tournament, Conway, SC |
| 3/5/2006 |
| West Virginia |
| W 8-1 | Coastal Carolina Tournament, Conway, SC |
| 3/7/2006 |
| Wake Forest |
| L 8-5 |
|
| 3/10/2006 | at | South Alabama |
| L 6-5 |
|
| 3/11/2006 | at | South Alabama |
| L 10-2 |
|
| 3/12/2006 | vs | Georgia Southern |
| W 17-13 | Mobile, AL |
| 3/17/2006 |
| High Point | * | W 5-4 |
|
| 3/18/2006 |
| High Point | * | L 7-6 | 10 innings |
| 3/19/2006 |
| High Point | * | W 10-2 |
|
| 3/21/2006 | at | College of Charleston |
| L 3-1 |
|
| 3/22/2006 |
| Savannah State |
| W 5-4 | 10 innings |
| 3/24/2006 | at | Charleston Southern | * | W 6-1 |
|
| 3/25/2006 | at | Charleston Southern | * | W 5-3 |
|
| 3/25/2006 | at | Charleston Southern | * | L 9-5 |
|
| 3/29/2006 | at | Georgia Southern |
| W 7-4 |
|
| 4/4/2006 | at | Wake Forest |
| W 6-5 |
|
| 4/7/2006 |
| Winthrop | * | L 8-0 |
|
| 4/8/2006 |
| Winthrop | * |
| PPD to 4/9, rain |
| 4/9/2006 |
| Winthrop | * | W 14-13 | makeup of 4/8 game |
| 4/9/2006 |
| Winthrop | * | L 8-2 |
|
| 4/11/2006 | at | Campbell |
| W 11-1 |
|
| 4/12/2006 |
| The Citadel |
| L 10-6 |
|
| 4/14/2006 |
| Birmingham-Southern | * | L 13-10 |
|
| 4/15/2006 |
| Birmingham-Southern | * | L 10-5 |
|
| 4/15/2006 |
| Birmingham-Southern | * | W 7-6 |
|
| 4/18/2006 |
| College of Charleston |
| W 10-3 |
|
| 4/22/2006 | at | Liberty | * |
| suspended to 4/23, rain (6-3 Liberty, Top 7th) |
| 4/23/2006 | at | Liberty | * | L 6-4 | resumption of suspended game |
| 4/23/2006 | at | Liberty | * | W 8-6 | 10 innings |
| 4/24/2006 | at | Liberty | * | L 4-3 | 12 innings (moved from 4/21, impending weather) |
| 4/25/2006 |
| Campbell |
| W 7-2 |
|
| 4/28/2006 |
| Texas-Pan American |
| W 2-0 |
|
| 4/29/2006 |
| Texas-Pan American |
| L 2-1 | 11 innings |
| 4/29/2006 |
| Texas-Pan American |
| W 9-7 |
|
| 5/6/2006 | at | Virginia Military | * | L 8-2 |
|
| 5/7/2006 | at | Virginia Military | * |
| PPD to 5/8, rain |
| 5/8/2006 | at | Virginia Military | * | W 6-4 | 10 innings (makeup of 5/7 game) |
| 5/8/2006 | at | Virginia Military | * | W 2-0 |
|
| 5/10/2006 | at | East Carolina |
| L 10-3 |
|
| 5/12/2006 | at | Radford | * | W 11-0 | Gary Gilmore's 400th win at CCU |
| 5/13/2006 | at | Radford | * | W 14-1 |
|
| 5/13/2006 | at | Radford | * | W 7-4 | moved from 5/14, impending weather |
| 5/16/2006 |
| East Carolina |
| W 9-4 |
|
| 5/19/2006 |
| North Carolina-Asheville | * | W 7-3 |
|
| 5/20/2006 |
| North Carolina-Asheville | * |
| suspended to 5/21, rain (5-0 CCU, Top 5) |
| 5/21/2006 |
| North Carolina-Asheville | * | W 6-1 | resumption of suspended game |
| 5/21/2006 |
| North Carolina-Asheville | * | W 13-5 |
|
| 5/24/2006 |
| High Point | BIGSOUTH-03 | L 1-0 | 10 innings (Big South Tournament, Game 3, Conway, SC) |
| 5/25/2006 |
| North Carolina-Asheville | BIGSOUTH-05 | W 6-1 | Big South Tournament, Game 5, Conway, SC |
| 5/26/2006 |
| Winthrop | BIGSOUTH-08 | L 4-3 | 10 innings (Big South Tournament, Game 8, Conway, SC) |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/15/2006 | at | Furman |
| W 5-3 | 11 innings |
| 2/17/2006 | at | Florida State |
| L 10-0 |
|
| 2/18/2006 | at | Florida State |
| L 9-1 |
|
| 2/19/2006 | at | Florida State |
| L 8-2 |
|
| 2/24/2006 | at | Georgia State |
| L 8-0 |
|
| 2/25/2006 | at | Georgia State |
|
| PPD to 2/26, rain |
| 2/25/2006 | at | Georgia State |
|
| PPD to 2/26, rain |
| 2/26/2006 | at | Georgia State |
| L 14-13 |
|
| 2/26/2006 | at | Georgia State |
| L 5-2 |
|
| 2/28/2006 | at | Western Carolina |
| L 16-5 |
|
| 3/1/2006 | at | North Carolina A&T |
| W 12-6 |
|
| 3/3/2006 | vs | Michigan |
| W 8-6 | Georgia Southern Invitational, Statesboro, GA |
| 3/4/2006 | vs | LeMoyne |
| L 14-6 | Georgia Southern Invitational, Statesboro, GA |
| 3/5/2006 | at | Georgia Southern |
| W 10-3 | Georgia Southern Invitational, Statesboro, GA |
| 3/7/2006 | at | Dallas Baptist |
| L 16-6 |
|
| 3/8/2006 | at | Texas-Arlington |
| W 4-3 |
|
| 3/9/2006 | at | Texas Tech |
| L 10-8 |
|
| 3/10/2006 | at | Texas Tech |
| L 8-7 |
|
| 3/11/2006 | at | Texas Tech |
| L 7-4 |
|
| 3/14/2006 |
| North Carolina A&T |
| W 13-2 |
|
| 3/15/2006 |
| Furman |
| W 6-5 |
|
| 3/18/2006 |
| Hartford |
| W 12-9 |
|
| 3/18/2006 |
| Hartford |
| W 13-8 |
|
| 3/19/2006 |
| Hartford |
| W 7-1 |
|
| 3/21/2006 | at | Appalachian State |
|
| PPD, inclement weather |
| 3/24/2006 | at | Birmingham-Southern | * | L 12-7 |
|
| 3/25/2006 | at | Birmingham-Southern | * | L 11-7 |
|
| 3/26/2006 | at | Birmingham-Southern | * | L 9-2 |
|
| 3/29/2006 |
| Western Carolina |
|
| CCD, ballpark construction |
| 3/31/2006 | at | Radford | * | W 10-9 | 10 innings |
| 4/1/2006 | at | Radford | * | W 9-1 |
|
| 4/2/2006 | at | Radford | * | W 7-4 |
|
| 4/5/2006 | at | North Carolina-Greensboro |
| L 2-0 |
|
| 4/7/2006 |
| Charleston Southern | * | W 9-2 |
|
| 4/8/2006 |
| Charleston Southern | * | L 10-4 |
|
| 4/9/2006 |
| Charleston Southern | * | L 5-2 |
|
| 4/11/2006 | at | East Tennessee State |
| L 8-6 |
|
| 4/12/2006 | at | Tennessee |
| W 5-2 |
|
| 4/14/2006 |
| Winthrop | * | L 11-4 |
|
| 4/15/2006 |
| Winthrop | * | L 13-11 |
|
| 4/15/2006 |
| Winthrop | * | L 15-6 |
|
| 4/19/2006 | at | Gardner-Webb |
|
| CCD, rain |
| 4/21/2006 | at | High Point | * |
| PPD to 4/24, rain |
| 4/22/2006 | at | High Point | * | W 6-2 |
|
| 4/23/2006 | at | High Point | * | L 3-2 |
|
| 4/24/2006 | at | High Point | * | L 2-0 | makeup of 4/21 game |
| 4/25/2006 |
| Gardner-Webb |
| L 10-6 |
|
| 4/26/2006 | at | Tennessee |
| L 9-2 |
|
| 4/28/2006 |
| Virginia Military | * | W 9-0 |
|
| 4/29/2006 |
| Virginia Military | * | W 10-4 |
|
| 4/30/2006 |
| Virginia Military | * | W 6-5 |
|
| 5/2/2006 |
| East Tennessee State |
| L 14-7 |
|
| 5/5/2006 |
| Campbell |
|
| PPD to 5/6, rain |
| 5/6/2006 |
| Campbell |
| W 6-3 | makeup of 5/5 game |
| 5/6/2006 |
| Campbell |
| W 7-1 |
|
| 5/12/2006 |
| Liberty | * | W 8-3 |
|
| 5/13/2006 |
| Liberty | * | L 20-3 |
|
| 5/13/2006 |
| Liberty | * | W 4-2 | moved from 5/14, impending weather |
| 5/16/2006 | at | Duke |
| W 14-2 |
|
| 5/17/2006 | at | Duke |
| L 5-4 |
|
| 5/19/2006 | at | Coastal Carolina | * | L 7-3 |
|
| 5/20/2006 | at | Coastal Carolina | * |
| suspended to 5/21, rain (5-0 CCU, Top 5) |
| 5/21/2006 | at | Coastal Carolina | * | L 6-1 | resumption of suspended game |
| 5/21/2006 | at | Coastal Carolina | * | L 13-5 |
|
| 5/24/2006 | vs | Birmingham-Southern | BIGSOUTH-01 | W 2-0 | Big South Tournament, Game 1, Conway, SC |
| 5/25/2006 | at | Coastal Carolina | BIGSOUTH-05 | L 6-1 | Big South Tournament, Game 5, Conway, SC |
| 5/26/2006 | vs | High Point | BIGSOUTH-07 | W 12-2 | Big South Tournament, Game 7, Conway, SC |
| 5/26/2006 | vs | Liberty | BIGSOUTH-09 |
| suspended to 5/27, rain (3-1 UNCA, Top 8) (Big South Tournament) |
| 5/27/2006 | vs | Liberty | BIGSOUTH-11 | W 16-11 | Big South Tournament, Game 11, Conway, SC (if necessary) |
|