| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/18/2006 | at | Western Carolina |
|
| PPD to 2/19, inclement weather |
| 2/18/2006 | at | Western Carolina |
|
| CCD, inclement weather |
| 2/19/2006 | at | Western Carolina |
| W 5-3 | 10 innings |
| 2/19/2006 | at | Western Carolina |
| L 4-2 | makeup of 2/18 game |
| 2/22/2006 |
| Marian (IN) |
| W 5-3 |
|
| 2/24/2006 |
| IUPU-Fort Wayne |
| W 9-2 |
|
| 2/28/2006 |
| Anderson (IN) |
| W 6-3 |
|
| 3/3/2006 | at | Western Kentucky |
| L 9-3 |
|
| 3/4/2006 | at | Western Kentucky |
| L 12-10 |
|
| 3/5/2006 | at | Western Kentucky |
| L 3-2 |
|
| 3/7/2006 |
| Dayton |
| L 7-6 |
|
| 3/8/2006 |
| Taylor |
|
| PPD, rain |
| 3/10/2006 | at | The Citadel |
| L 11-2 | 500th career victory for Fred Jordan |
| 3/11/2006 | at | The Citadel |
| L 4-3 | 11 innings |
| 3/12/2006 | at | The Citadel |
| W 10-6 | 11 innings |
| 3/14/2006 | at | Vanderbilt |
| L 14-6 |
|
| 3/15/2006 | at | Vanderbilt |
| L 8-2 |
|
| 3/18/2006 | at | Wright State | * | W 10-8 |
|
| 3/18/2006 | at | Wright State | * | W 6-5 |
|
| 3/19/2006 | at | Wright State | * | L 6-2 | moved from 3/17, impending weather |
| 3/21/2006 | at | IUPU-Fort Wayne |
|
| PPD, inclement weather |
| 3/22/2006 |
| Marian |
|
| PPD |
| 3/25/2006 |
| Youngstown State | * | W 12-4 |
|
| 3/25/2006 |
| Youngstown State | * |
| suspended to 3/26, darkness (Tied 3-3, Top 10) |
| 3/26/2006 |
| Youngstown State | * | L 7-3 | resumption of suspended game (11 innings) |
| 3/26/2006 |
| Youngstown State | * | L 11-10 | 12 innings |
| 3/29/2006 |
| Indiana |
| W 6-5 |
|
| 4/1/2006 |
| Cleveland State | * | W 5-0 |
|
| 4/1/2006 |
| Cleveland State | * | W 5-2 |
|
| 4/2/2006 |
| Cleveland State | * | W 15-8 |
|
| 4/4/2006 |
| Xavier |
| L 5-0 |
|
| 4/5/2006 | at | Marian |
| L 11-5 |
|
| 4/8/2006 | at | Wisconsin-Milwaukee | * | L 3-2 |
|
| 4/8/2006 | at | Wisconsin-Milwaukee | * | L 3-1 | 10 innings |
| 4/9/2006 | at | Wisconsin-Milwaukee | * | L 4-2 |
|
| 4/11/2006 |
| Wright State | * | L 12-4 |
|
| 4/11/2006 |
| Wright State | * | W 13-6 |
|
| 4/15/2006 | at | Cleveland State | * | W 9-5 |
|
| 4/15/2006 | at | Cleveland State | * | L 4-3 |
|
| 4/16/2006 | at | Cleveland State | * | L 13-10 |
|
| 4/18/2006 |
| Wright State | * | L 8-3 |
|
| 4/20/2006 | at | Marian (IN) |
| W 8-4 |
|
| 4/22/2006 |
| Illinois-Chicago | * | L 19-10 |
|
| 4/22/2006 |
| Illinois-Chicago | * | L 8-1 |
|
| 4/23/2006 |
| Illinois-Chicago | * | L 4-1 |
|
| 4/26/2006 | at | Ball State |
| L 8-3 |
|
| 4/29/2006 | at | Youngstown State | * | L 10-4 |
|
| 4/29/2006 | at | Youngstown State | * | W 5-1 |
|
| 4/30/2006 | at | Youngstown State | * | L 10-6 |
|
| 5/2/2006 |
| Indianapolis |
| W 8-5 |
|
| 5/10/2006 |
| Evansville |
|
| CCD, rain |
| 5/12/2006 | at | Illinois-Chicago | * |
| PPD to 5/14, rain |
| 5/13/2006 | at | Illinois-Chicago | * | L 18-1 |
|
| 5/13/2006 | at | Illinois-Chicago | * | L 20-5 |
|
| 5/14/2006 | at | Illinois-Chicago | * | L 12-0 | makeup of 5/12 game |
| 5/16/2006 | at | Indiana State |
| L 7-0 |
|
| 5/17/2006 | at | IUPU-Fort Wayne |
| W 6-5 |
|
| 5/19/2006 |
| Wisconsin-Milwaukee | * | L 12-5 |
|
| 5/20/2006 |
| Wisconsin-Milwaukee | * | L 8-3 |
|
| 5/20/2006 |
| Wisconsin-Milwaukee | * | L 9-5 |
|
| 5/24/2006 | vs | Youngstown State | HORIZON-01 | W 5-3 | 10 innings (Horizon Tournament, Game 1, Dayton, OH) |
| 5/25/2006 | vs | Illinois-Chicago | HORIZON-05 |
| PPD to 5/26, rain (Horizon Tournament) |
| 5/26/2006 | vs | Illinois-Chicago | HORIZON-05 | W 6-4 | Horizon Tournament, Game 5, Dayton, OH |
| 5/27/2006 | at | Wright State | HORIZON-08 | L 12-0 | Horizon Tournament, Game 8, Dayton, OH |
| 5/27/2006 | vs | Illinois-Chicago | HORIZON-09 | W 8-6 | Horizon Tournament, Game 9, Dayton, OH |
| 5/28/2006 | at | Wright State | HORIZON-10 | L 4-1 | Horizon Tournament, Game 10, Dayton, OH |