| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/24/2006 | at | The Citadel |
| L 8-5 | Sandlapper Shootout, Charleston, SC |
| 2/25/2006 | vs | Towson |
| L 8-4 | Sandlapper Shootout, Charleston, SC |
| 2/26/2006 | vs | Ball State |
| W 13-8 | Sandlapper Shootout, Charleston, SC |
| 2/28/2006 | at | Charleston Southern |
| L 8-0 |
|
| 3/1/2006 | at | The Citadel |
| L 4-3 |
|
| 3/3/2006 | at | Georgia Southern |
| W 6-4 | Georgia Southern Invitational, Statesboro, GA |
| 3/4/2006 | vs | North Carolina-Asheville |
| W 14-6 | Georgia Southern Invitational, Statesboro, GA |
| 3/5/2006 | vs | Michigan |
| L 9-4 | Georgia Southern Invitational, Statesboro, GA |
| 3/10/2006 | at | Ohio |
| W 11-3 |
|
| 3/11/2006 | at | Ohio |
|
| PPD to 3/12, rain |
| 3/11/2006 | at | Ohio |
|
| CCD, rain |
| 3/12/2006 | at | Ohio |
|
| CCD, field conditions (makeup of 3/11 game) |
| 3/12/2006 | at | Ohio |
|
| CCD, field conditions |
| 3/17/2006 | at | North Carolina-Charlotte |
| W 7-4 |
|
| 3/18/2006 | at | North Carolina-Charlotte |
| W 9-6 |
|
| 3/19/2006 | at | North Carolina-Charlotte |
| L 9-2 |
|
| 3/25/2006 | at | Fairfield | * | L 4-3 | 12 innings |
| 3/25/2006 | at | Fairfield | * | W 6-0 |
|
| 3/26/2006 | at | Fairfield | * | L 4-3 |
|
| 3/28/2006 | at | Bucknell |
| W 2-0 |
|
| 3/28/2006 | at | Bucknell |
| W 7-4 |
|
| 4/1/2006 | at | Iona | * | W 22-6 |
|
| 4/1/2006 | at | Iona | * | W 9-5 |
|
| 4/2/2006 | at | Iona | * | W 6-1 |
|
| 4/5/2006 |
| St. Bonaventure |
|
| PPD to 5/15, inclement weather |
| 4/5/2006 |
| St. Bonaventure |
|
| PPD to 5/15, inclement weather |
| 4/8/2006 |
| Manhattan | * | L 2-1 |
|
| 4/8/2006 |
| Manhattan | * | W 1-0 | No-hitter for TJ Sheridan (LeMoyne) |
| 4/9/2006 |
| Manhattan | * | L 4-2 |
|
| 4/11/2006 | at | Cornell |
| W 2-0 |
|
| 4/11/2006 | at | Cornell |
| W 19-5 |
|
| 4/14/2006 | at | Siena | * |
| PPD to 4/16, rain (Troy, NY) |
| 4/15/2006 | at | Siena | * | W 3-2 |
|
| 4/15/2006 | at | Siena | * | W 7-3 |
|
| 4/16/2006 | at | Siena | * | L 4-2 | makeup of 4/14 game |
| 4/18/2006 |
| Albany |
| W 7-5 |
|
| 4/19/2006 |
| Cornell |
| W 15-3 |
|
| 4/19/2006 |
| Cornell |
| W 6-4 |
|
| 4/22/2006 | at | St. Peter's | * |
| PPD to 4/23, rain |
| 4/22/2006 | at | St. Peter's | * |
| PPD to 4/24, rain |
| 4/23/2006 | at | St. Peter's | * |
| CCD, field conditions (makeup of 4/22 game) |
| 4/23/2006 | at | St. Peter's | * |
| CCD, field conditions |
| 4/24/2006 | at | St. Peter's | * | W 12-0 | makeup of 4/22 game |
| 4/24/2006 | at | St. Peter's | * | W 14-2 | makeup of 4/22 game |
| 4/26/2006 |
| Binghamton |
| W 10-6 |
|
| 4/29/2006 |
| Canisius | * | W 6-0 | Bobby Blevins strikes out 18 batters (LeMoyne record) |
| 4/29/2006 |
| Canisius | * | W 4-2 |
|
| 4/30/2006 |
| Canisius | * | W 8-4 |
|
| 5/3/2006 |
| Buffalo |
| W 5-3 |
|
| 5/3/2006 |
| Buffalo |
| L 6-3 |
|
| 5/6/2006 | at | Niagara | * | W 11-4 |
|
| 5/6/2006 | at | Niagara | * | W 5-4 |
|
| 5/7/2006 | at | Niagara | * | W 8-7 |
|
| 5/13/2006 |
| Marist | * | W 3-1 |
|
| 5/13/2006 |
| Marist | * | W 7-5 |
|
| 5/14/2006 |
| Marist | * | W 13-7 |
|
| 5/15/2006 |
| St. Bonaventure |
|
| CCD, rain (makeup of 4/5 game) |
| 5/16/2006 | at | Albany |
|
| PPD, inclement weather |
| 5/18/2006 |
| Rider | * | W 6-4 |
|
| 5/18/2006 |
| Rider | * |
| PPD to 5/19, rain |
| 5/19/2006 |
| Rider | * | W 10-4 | makeup of 5/18 game |
| 5/19/2006 |
| Rider | * | W 5-3 |
|
| 5/25/2006 | vs | Niagara | MAAC-01 | W 7-2 | MAAC Tournament, Game 1, Fishkill, NY |
| 5/26/2006 | vs | Manhattan | MAAC-04 | L 3-2 | MAAC Tournament, Game 4, Fishkill, NY |
| 5/26/2006 | vs | Niagara | MAAC-05 | W 4-3 | MAAC Tournament, Game 5, Fishkill, NY |
| 5/27/2006 | vs | Manhattan | MAAC-06 | L 7-3 | MAAC Tournament, Game 6, Fishkill, NY |