| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/18/2006 |
| Buffalo |
|
| PPD to 2/19, rain (Kannapolis, NC) |
| 2/18/2006 |
| Buffalo |
|
| CCD, rain (Kannapolis, NC) |
| 2/19/2006 |
| Buffalo |
| W 12-6 | Kannapolis, NC |
| 2/19/2006 |
| Buffalo |
| L 4-2 | makeup of 2/18 game (Kannapolis, NC) |
| 2/21/2006 | at | Gardner-Webb |
|
| suspended to 3/28, darkness (4-4, Top 13) |
| 2/25/2006 | vs | Army |
| W 11-8 | Davidson, NC |
| 2/25/2006 | vs | Niagara |
| W 7-6 | Davidson, NC (13 innings) |
| 2/26/2006 | vs | Army |
| W 4-2 | Davidson, NC |
| 2/28/2006 |
| Campbell |
| W 12-7 |
|
| 3/3/2006 | at | Alabama |
| L 4-3 | School record 488th win for Jim Wells |
| 3/4/2006 | at | Alabama |
| L 8-3 |
|
| 3/5/2006 | at | Alabama |
| L 8-3 |
|
| 3/8/2006 | at | North Carolina |
| L 6-4 |
|
| 3/10/2006 |
| Canisius |
| W 10-7 | Hickory, NC |
| 3/11/2006 |
| Canisius |
| W 6-4 | Hickory, NC |
| 3/11/2006 |
| Canisius |
| W 7-0 | Hickory, NC |
| 3/12/2006 |
| Canisius |
| W 11-3 | Hickory, NC |
| 3/14/2006 | at | Auburn |
| L 7-2 |
|
| 3/15/2006 | at | North Carolina A&T |
| L 3-2 | 10 innings |
| 3/17/2006 |
| College of Charleston | * | L 10-3 |
|
| 3/18/2006 |
| College of Charleston | * | L 8-2 |
|
| 3/19/2006 |
| College of Charleston | * | L 2-0 |
|
| 3/21/2006 |
| North Carolina-Asheville |
|
| PPD, inclement weather |
| 3/22/2006 | at | East Tennessee State |
|
| PPD, field conditions |
| 3/24/2006 | at | Elon | * | L 8-0 |
|
| 3/25/2006 | at | Elon | * |
| PPD to 3/26, inclement weather |
| 3/26/2006 | at | Elon | * | L 5-2 | makeup of 3/25 game |
| 3/26/2006 | at | Elon | * | L 9-8 |
|
| 3/28/2006 | at | Gardner-Webb |
| W 7-4 | resumption of suspended game (13 innings) |
| 3/28/2006 |
| Gardner-Webb |
| L 9-8 |
|
| 3/31/2006 |
| Western Carolina | * | L 11-0 |
|
| 4/1/2006 |
| Western Carolina | * | W 4-3 |
|
| 4/2/2006 |
| Western Carolina | * | L 15-4 |
|
| 4/4/2006 |
| North Carolina-Charlotte |
| T 13-13 |
|
| 4/7/2006 |
| North Carolina-Greensboro | * | L 20-10 |
|
| 4/8/2006 |
| North Carolina-Greensboro | * | W 11-8 |
|
| 4/9/2006 |
| North Carolina-Greensboro | * | L 7-4 |
|
| 4/11/2006 |
| North Carolina A&T |
| W 21-5 |
|
| 4/12/2006 | at | Virginia Tech |
| L 5-4 |
|
| 4/14/2006 | at | Wofford | * | W 16-3 |
|
| 4/15/2006 | at | Wofford | * | W 10-3 |
|
| 4/15/2006 | at | Wofford | * | L 8-6 |
|
| 4/18/2006 |
| North Carolina A&T |
| W 16-11 |
|
| 4/21/2006 |
| Furman | * |
| PPD to 4/22, rain |
| 4/22/2006 |
| Furman | * | L 3-2 |
|
| 4/23/2006 |
| Furman | * | W 7-2 | makeup of 4/21 game |
| 4/23/2006 |
| Furman | * | L 17-11 |
|
| 4/25/2006 | at | North Carolina-Charlotte |
| L 4-3 |
|
| 4/26/2006 |
| East Tennessee State |
|
| PPD to 4/30, rain |
| 4/30/2006 |
| East Tennessee State |
| W 5-4 | makeup of 4/26 game |
| 5/5/2006 | at | The Citadel | * | L 7-2 |
|
| 5/6/2006 | at | The Citadel | * | W 7-2 | 10 innings |
| 5/7/2006 | at | The Citadel | * | L 4-3 |
|
| 5/10/2006 |
| Longwood |
| W 8-6 |
|
| 5/12/2006 | at | Georgia Southern | * | L 4-1 |
|
| 5/13/2006 | at | Georgia Southern | * | L 8-6 |
|
| 5/14/2006 | at | Georgia Southern | * | W 12-7 |
|
| 5/16/2006 | at | North Carolina A&T |
| L 9-3 |
|
| 5/18/2006 |
| Davidson | * |
| suspended to 5/19, rain (5-4 Davidson, Bottom 6) |
| 5/19/2006 |
| Davidson | * | W 10-9 | 10 innings (resumption of suspended game) |
| 5/19/2006 |
| Davidson | * | W 9-8 |
|
| 5/20/2006 |
| Davidson | * | L 6-5 | 12 innings |
| 5/23/2006 | vs | Davidson | SOCON-02 | W 5-4 | Southern Tournament, Game 2, Charleston, SC |
| 5/24/2006 | vs | Elon | SOCON-05 | L 4-3 | Southern Tournament, Game 5, Charleston, SC |
| 5/25/2006 | vs | Georgia Southern | SOCON-08 | L 5-2 | Southern Tournament, Game 8, Charleston, SC |
| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/10/2006 |
| High Point |
| W 16-4 |
|
| 2/11/2006 |
| High Point |
| W 12-6 |
|
| 2/12/2006 |
| High Point |
| W 9-3 |
|
| 2/17/2006 | at | East Carolina |
| L 5-0 |
|
| 2/18/2006 | at | East Carolina |
| L 4-2 |
|
| 2/19/2006 | at | East Carolina |
| W 11-8 |
|
| 2/22/2006 |
| Savannah State |
| W 14-1 |
|
| 2/24/2006 |
| Hofstra |
| W 13-3 | Charleston Challenge, Charleston, SC |
| 2/25/2006 |
| George Mason |
|
| CCD, rain (Charleston Challenge, Charleston, SC) |
| 2/26/2006 |
| Virginia |
| W 7-6 | Charleston Challenge, Charleston, SC (17 innings) |
| 3/3/2006 |
| Clemson |
| L 6-0 |
|
| 3/4/2006 |
| Georgia State |
| W 2-1 |
|
| 3/4/2006 |
| Georgia State |
| W 20-7 |
|
| 3/5/2006 |
| Georgia State |
| W 15-2 |
|
| 3/10/2006 |
| St. John's |
| W 6-2 |
|
| 3/11/2006 |
| St. John's |
| W 4-3 |
|
| 3/12/2006 |
| St. John's |
| L 10-8 |
|
| 3/14/2006 |
| North Carolina-Charlotte |
| W 10-8 |
|
| 3/15/2006 | at | Charleston Southern |
| W 8-5 |
|
| 3/17/2006 | at | Appalachian State | * | W 10-3 |
|
| 3/18/2006 | at | Appalachian State | * | W 8-2 |
|
| 3/19/2006 | at | Appalachian State | * | W 2-0 |
|
| 3/21/2006 |
| Coastal Carolina |
| W 3-1 |
|
| 3/24/2006 | at | North Carolina-Greensboro | * | L 3-2 |
|
| 3/25/2006 | at | North Carolina-Greensboro | * | W 5-0 |
|
| 3/26/2006 | at | North Carolina-Greensboro | * | W 3-0 |
|
| 3/29/2006 |
| Charleston Southern |
| W 11-9 |
|
| 3/31/2006 |
| Elon | * | W 5-1 |
|
| 4/1/2006 |
| Elon | * | W 3-2 |
|
| 4/2/2006 |
| Elon | * | L 8-1 |
|
| 4/4/2006 |
| Winthrop |
| W 8-3 |
|
| 4/7/2006 | at | Davidson | * | W 12-3 |
|
| 4/8/2006 | at | Davidson | * |
| PPD to 4/10, rain |
| 4/9/2006 | at | Davidson | * | W 6-1 | makeup of 4/8 game |
| 4/9/2006 | at | Davidson | * | W 11-3 |
|
| 4/11/2006 | at | Winthrop |
| W 5-2 |
|
| 4/14/2006 | at | Western Carolina | * | W 17-1 |
|
| 4/15/2006 | at | Western Carolina | * | W 14-6 |
|
| 4/16/2006 | at | Western Carolina | * | L 5-4 |
|
| 4/18/2006 | at | Coastal Carolina |
| L 10-3 |
|
| 4/19/2006 |
| Charleston Southern |
| L 2-1 |
|
| 4/21/2006 |
| Wofford | * | W 11-4 |
|
| 4/22/2006 |
| Wofford | * | W 6-1 |
|
| 4/23/2006 |
| Wofford | * | W 6-3 |
|
| 4/25/2006 | at | The Citadel |
| L 4-1 |
|
| 5/6/2006 |
| Georgia Southern | * | L 5-4 | 10 innings |
| 5/7/2006 |
| Georgia Southern | * |
| PPD to 5/8, rain |
| 5/8/2006 |
| Georgia Southern | * | W 5-2 | makeup of 5/7 game |
| 5/8/2006 |
| Georgia Southern | * | W 4-1 |
|
| 5/10/2006 | at | Charleston Southern |
| W 8-5 |
|
| 5/12/2006 | at | Furman | * | W 3-2 |
|
| 5/13/2006 | at | Furman | * | L 5-4 | 10 innings |
| 5/14/2006 | at | Furman | * | W 7-1 |
|
| 5/16/2006 | at | Clemson |
| L 1-0 |
|
| 5/18/2006 |
| The Citadel | * | L 4-2 |
|
| 5/19/2006 |
| The Citadel | * | W 7-5 |
|
| 5/20/2006 |
| The Citadel | * | L 11-10 |
|
| 5/24/2006 | vs | North Carolina-Greensboro | SOCON-04 | W 13-5 | Southern Tournament, Game 4, Charleston, SC |
| 5/25/2006 | vs | Western Carolina | SOCON-09 | W 1-0 | Southern Tournament, Game 9, Charleston, SC |
| 5/26/2006 | vs | Elon | SOCON-13 | W 12-1 | Southern Tournament, Game 13, Charleston, SC |
| 5/27/2006 | at | The Citadel | SOCON-16 | W 5-4 | Southern Tournament, Game 16, Charleston, SC |
| 6/2/2006 | vs | Notre Dame |
| W 5-4 | 16 innings (Lexington Regional, Game 1) |
| 6/3/2006 | vs | Ball State |
| W 11-0 | Lexington Regional, Game 4 |
| 6/4/2006 | vs | Kentucky |
| W 7-4 | Lexington Regional, Game 6 |
| 6/9/2006 | vs | Georgia Tech |
| L 5-0 | Atlanta Super Regional, Game 1 |
| 6/10/2006 | vs | Georgia Tech |
| L 12-3 | Atlanta Super Regional, Game 2 |