| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 2/27/2008 |
| Texas-Pan American | 0 | at | #3 Texas | 5 | FINAL | Box Score | Recap | 7 innings |
| 2/27/2008 |
| Northwestern State | 1 | at | #4 Mississippi | 14 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| North Carolina-Asheville | 0 | at | #5 South Carolina | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Evansville | 3 | at | #7 Vanderbilt | 4 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Houston | 11 | at | #9 Rice | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| High Point | 3 | at | #13 Clemson | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Old Dominion | 3 | at | #19 Virginia | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Southern California | 3 | at | #20 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| UC Santa Barbara | 4 | at | #21 UCLA | 5 | FINAL | Box Score | Recap | 13 innings |
| 2/27/2008 |
| McNeese State | 3 | at | #27 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Georgia Southern | 0 | at | #28 Georgia Tech | 1 | FINAL | Box Score | Recap | 10 innings |
| 2/27/2008 |
| South Alabama | 2 | at | #29 Southern Mississippi | 4 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 2/27/2008 |
| Longwood | 6 | at | Richmond | 7 | FINAL | Box Score | Recap | 10 innings |
| 2/27/2008 |
| Mercyhurst | 9 | vs | St. Bonaventure | 3 | FINAL | Box Score | Recap | West Palm Beach, FL |
| 2/27/2008 |
| North Carolina-Charlotte | 7 | at | South Carolina-Upstate | 3 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| West Chester |
| at | LaSalle |
| Postponed | | Recap | PPD, cold |
| Atlantic Coast Conference |
| 2/27/2008 |
| High Point | 3 | at | #13 Clemson | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Old Dominion | 3 | at | #19 Virginia | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Georgia Southern | 0 | at | #28 Georgia Tech | 1 | FINAL | Box Score | Recap | 10 innings |
| 2/27/2008 |
| Alabama A&M | 0 | at | Duke | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Appalachian State | 18 | at | Wake Forest | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Virginia Tech | 14 | at | Davidson | 10 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 2/27/2008 | * | Stetson | 4 | at | Kennesaw State | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 | * | Stetson | 6 | at | Kennesaw State | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Florida Gulf Coast | 13 | at | Florida International | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Middle Tennessee State |
| at | Belmont |
| Postponed | | Recap | PPD to 2/28, inclement weather |
| 2/27/2008 |
| North Carolina A&T | 4 | at | Gardner-Webb | 15 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| North Carolina-Charlotte | 7 | at | South Carolina-Upstate | 3 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Savannah State | 1 | at | Mercer | 16 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Tennessee Tech |
| at | East Tennessee State |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| Big 12 Conference |
| 2/27/2008 |
| Texas-Pan American | 0 | at | #3 Texas | 5 | FINAL | Box Score | Recap | 7 innings |
| 2/27/2008 |
| McNeese State | 3 | at | #27 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Arkansas-Pine Bluff | 3 | at | Oklahoma | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Kansas | 1 | at | Arkansas | 2 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Texas Tech | 3 | at | New Mexico | 7 | FINAL | Box Score | Recap | |
| Big South Conference |
| 2/27/2008 |
| North Carolina-Asheville | 0 | at | #5 South Carolina | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| High Point | 3 | at | #13 Clemson | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Furman | 4 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Liberty | 5 | at | Norfolk State | 1 | FINAL | Box Score | Recap | moved from 2/26, impending weather |
| 2/27/2008 |
| VMI |
| at | James Madison |
| Postponed | | Recap | PPD to 3/26, cold |
| Big West Conference |
| 2/27/2008 |
| Southern California | 3 | at | #20 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| UC Santa Barbara | 4 | at | #21 UCLA | 5 | FINAL | Box Score | Recap | 13 innings |
| 2/27/2008 |
| Santa Clara | 15 | at | Pacific | 6 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 2/27/2008 |
| Old Dominion | 3 | at | #19 Virginia | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Coppin State | 1 | at | William and Mary | 10 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| North Carolina-Wilmington | 1 | at | The Citadel | 3 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| VMI |
| at | James Madison |
| Postponed | | Recap | PPD to 3/26, cold |
| Conference USA |
| 2/27/2008 |
| Houston | 11 | at | #9 Rice | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| South Alabama | 2 | at | #29 Southern Mississippi | 4 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| East Carolina | 6 | at | Elon | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Louisiana-Lafayette | 1 | at | Tulane | 10 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Murray State | 9 | at | Memphis | 8 | FINAL | Box Score | Recap | |
| Division I Independents |
| 2/27/2008 |
| Texas-Pan American | 0 | at | #3 Texas | 5 | FINAL | Box Score | Recap | 7 innings |
| 2/27/2008 |
| Longwood | 6 | at | Richmond | 7 | FINAL | Box Score | Recap | 10 innings |
| 2/27/2008 |
| North Carolina Central |
| at | Benedict |
| Postponed | | | PPD, inclement weather |
| 2/27/2008 |
| North Carolina Central |
| at | Benedict |
| Postponed | | | PPD, inclement weather |
| 2/27/2008 |
| Savannah State | 1 | at | Mercer | 16 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 2/27/2008 |
| Eastern Michigan | 2 | at | Florida | 15 | FINAL | Box Score | Recap | 7 innings (makeup of 2/26 game) |
| 2/27/2008 |
| Eastern Michigan | 8 | at | Florida | 16 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 2/27/2008 |
| Coppin State | 1 | at | William and Mary | 10 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Lehigh | 6 | at | Maryland-Eastern Shore | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Lehigh | 4 | at | Maryland-Eastern Shore | 2 | FINAL | Box Score | Recap | 8 innings |
| 2/27/2008 |
| Liberty | 5 | at | Norfolk State | 1 | FINAL | Box Score | Recap | moved from 2/26, impending weather |
| 2/27/2008 |
| North Carolina A&T | 4 | at | Gardner-Webb | 15 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 2/27/2008 |
| Evansville | 3 | at | #7 Vanderbilt | 4 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Southern Illinois |
| at | Tennessee-Martin |
| Postponed | | Recap | PPD to 2/28, cold and snow |
| Mountain West Conference |
| 2/27/2008 |
| Texas Tech | 3 | at | New Mexico | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Washington State | 9 | at | Nevada-Las Vegas | 5 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 2/27/2008 |
| Mount St. Mary's | 5 | at | Florida Atlantic | 13 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 2/27/2008 |
| Austin Peay State |
| at | Tennessee |
| Postponed | | Recap | PPD to 4/8, inclement weather |
| 2/27/2008 |
| Millsaps | 17 | at | Jacksonville State | 3 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Murray State | 9 | at | Memphis | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Southern Illinois |
| at | Tennessee-Martin |
| Postponed | | Recap | PPD to 2/28, cold and snow |
| 2/27/2008 |
| Tennessee Tech |
| at | East Tennessee State |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| Pac 10 Conference |
| 2/27/2008 |
| Southern California | 3 | at | #20 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| UC Santa Barbara | 4 | at | #21 UCLA | 5 | FINAL | Box Score | Recap | 13 innings |
| 2/27/2008 |
| Lewis-Clark State | 8 | at | Washington | 6 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Washington State | 9 | at | Nevada-Las Vegas | 5 | FINAL | Box Score | Recap | |
| Patriot League |
| 2/27/2008 |
| Lehigh | 6 | at | Maryland-Eastern Shore | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Lehigh | 4 | at | Maryland-Eastern Shore | 2 | FINAL | Box Score | Recap | 8 innings |
| Southeastern Conference |
| 2/27/2008 |
| Northwestern State | 1 | at | #4 Mississippi | 14 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| North Carolina-Asheville | 0 | at | #5 South Carolina | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Evansville | 3 | at | #7 Vanderbilt | 4 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Austin Peay State |
| at | Tennessee |
| Postponed | | Recap | PPD to 4/8, inclement weather |
| 2/27/2008 |
| Eastern Michigan | 2 | at | Florida | 15 | FINAL | Box Score | Recap | 7 innings (makeup of 2/26 game) |
| 2/27/2008 |
| Eastern Michigan | 8 | at | Florida | 16 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Kansas | 1 | at | Arkansas | 2 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Mississippi Valley State | 1 | at | Louisiana State | 9 | FINAL | Box Score | Recap | |
| Southern Conference |
| 2/27/2008 |
| Georgia Southern | 0 | at | #28 Georgia Tech | 1 | FINAL | Box Score | Recap | 10 innings |
| 2/27/2008 |
| Appalachian State | 18 | at | Wake Forest | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| East Carolina | 6 | at | Elon | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Furman | 4 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| North Carolina-Wilmington | 1 | at | The Citadel | 3 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Virginia Tech | 14 | at | Davidson | 10 | FINAL | Box Score | Recap | |
| Southland Conference |
| 2/27/2008 |
| Northwestern State | 1 | at | #4 Mississippi | 14 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| McNeese State | 3 | at | #27 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Houston Baptist | 3 | at | Stephen F. Austin | 10 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Mobile | 13 | at | Southeastern Louisiana | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| New Orleans | 20 | at | Nicholls State | 1 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 2/27/2008 |
| Alabama A&M | 0 | at | Duke | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Arkansas-Pine Bluff | 3 | at | Oklahoma | 9 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Grambling State | 6 | at | Jackson State | 12 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Mississippi Valley State | 1 | at | Louisiana State | 9 | FINAL | Box Score | Recap | |
| Summit League |
| 2/27/2008 |
| Texas College | 1 | at | Centenary | 11 | FINAL | Box Score | Recap | 7 innings |
| 2/27/2008 |
| Texas College | 2 | at | Centenary | 13 | FINAL | Box Score | Recap | 7 innings |
| Sun Belt Conference |
| 2/27/2008 |
| South Alabama | 2 | at | #29 Southern Mississippi | 4 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Florida Gulf Coast | 13 | at | Florida International | 1 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Louisiana Tech | 11 | at | Louisiana-Monroe | 7 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Louisiana-Lafayette | 1 | at | Tulane | 10 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| Middle Tennessee State |
| at | Belmont |
| Postponed | | Recap | PPD to 2/28, inclement weather |
| 2/27/2008 |
| Mount St. Mary's | 5 | at | Florida Atlantic | 13 | FINAL | Box Score | Recap | |
| 2/27/2008 |
| New Orleans | 20 | at | Nicholls State | 1 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 2/27/2008 |
| Santa Clara | 15 | at | Pacific | 6 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 2/27/2008 |
| Louisiana Tech | 11 | at | Louisiana-Monroe | 7 | FINAL | Box Score | Recap | |