| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 3/21/2008 |
| Northern Colorado | 6 | at | #1 Arizona State | 3 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 | * | #2 Arizona | 10 | at | Southern California | 2 | FINAL | Box Score | Recap | makeup of 3/20 game |
| 3/21/2008 | * | #2 Arizona | 0 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #3 North Carolina | 2 | at | Maryland | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Wake Forest | 4 | at | #4 Miami, Florida | 17 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #5 Florida State | 9 | at | Virginia Tech | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #6 Vanderbilt | 2 | at | Alabama | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| #7 Long Beach State | 13 | at | #17 UCLA | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Mississippi State | 1 | at | #8 South Carolina | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Florida International | 2 | vs | #9 UC Irvine | 5 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 | * | #10 Texas | 5 | at | Texas Tech | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #16 Baylor | 0 | at | #11 Missouri | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #12 Kentucky | 0 | at | Auburn | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #13 Rice | 6 | at | Marshall | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Florida | 4 | at | #14 Mississippi | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #15 Wichita State |
| at | Illinois State |
| Postponed | | Recap | PPD to 3/22, field conditions |
| 3/21/2008 |
| Albany | 1 | at | #18 Coastal Carolina | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #19 Texas A&M | 9 | at | #26 Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Boston College | 3 | at | #20 Virginia | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | North Carolina State | 5 | at | #21 Clemson | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Nevada-Las Vegas | 5 | at | #23 Cal State Fullerton | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #24 California | 7 | at | Washington State | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| #29 Pepperdine | 3 | at | #25 Oregon State | 10 | FINAL | Box Score | Recap | Resumption of 3/20 game |
| 3/21/2008 |
| #29 Pepperdine | 7 | at | #25 Oregon State | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Pacific | 10 | at | #27 Stanford | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Duke | 4 | at | #28 Georgia Tech | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #30 UCF | 4 | at | Southern Mississippi | 8 | FINAL | Box Score | Recap | 900th career win for USM's Corky Palmer |
| America East Conference |
| 3/21/2008 |
| Albany | 1 | at | #18 Coastal Carolina | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Binghamton | 4 | at | Kansas State | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Hartford | 11 | at | North Carolina-Asheville | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Kansas | 4 | vs | Maryland-Baltimore County | 1 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, travel problems |
| Atlantic 10 Conference |
| 3/21/2008 | * | LaSalle | 10 | at | Richmond | 15 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Massachusetts | 0 | at | Duquesne | 2 | FINAL | Box Score | Recap | Greensburg, PA |
| 3/21/2008 | * | Massachusetts | 2 | at | Duquesne | 6 | FINAL | Box Score | Recap | makeup of 3/20 game (Greensburg, PA) |
| 3/21/2008 | * | St. Bonaventure | 3 | at | Fordham | 2 | FINAL | Box Score | Recap | 12 innings |
| 3/21/2008 | * | St. Joseph's | 7 | at | George Washington | 12 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | St. Joseph's | 10 | at | George Washington | 8 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | St. Louis | 6 | at | North Carolina-Charlotte | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Temple | 10 | at | Rhode Island | 6 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 3/21/2008 | * | #3 North Carolina | 2 | at | Maryland | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Wake Forest | 4 | at | #4 Miami, Florida | 17 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #5 Florida State | 9 | at | Virginia Tech | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Boston College | 3 | at | #20 Virginia | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | North Carolina State | 5 | at | #21 Clemson | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Duke | 4 | at | #28 Georgia Tech | 5 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 3/21/2008 | * | Belmont | 6 | at | Kennesaw State | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/21/2008 | * | Belmont | 2 | at | Kennesaw State | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Campbell | 1 | at | Stetson | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Campbell | 5 | at | Stetson | 6 | FINAL | Box Score | Recap | 11 innings |
| 3/21/2008 | * | East Tennessee State | 5 | at | Jacksonville | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Gardner-Webb | 4 | at | Lipscomb | 8 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Gardner-Webb | 5 | at | Lipscomb | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | South Carolina-Upstate | 12 | at | North Florida | 5 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 3/21/2008 |
| Central Connecticut State | 8 | vs | Illinois | 7 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Illinois | 5 | vs | Central Connecticut State | 4 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| IUPU-Fort Wayne |
| at | Michigan |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| 3/21/2008 |
| Lehigh | 9 | at | Penn State | 18 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Northern Iowa | 6 | vs | Northwestern | 0 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Northwestern | 1 | vs | Northern Iowa | 2 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Oakland |
| at | Michigan State |
| Postponed | | Recap | PPD to 3/22, snow |
| 3/21/2008 |
| Ohio State | 16 | vs | Kansas | 5 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| South Dakota State | 1 | at | Minnesota | 3 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 3/21/2008 | * | #10 Texas | 5 | at | Texas Tech | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #16 Baylor | 0 | at | #11 Missouri | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #19 Texas A&M | 9 | at | #26 Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Oklahoma | 2 | at | Nebraska | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Binghamton | 4 | at | Kansas State | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Kansas | 4 | vs | Maryland-Baltimore County | 1 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Ohio State | 16 | vs | Kansas | 5 | FINAL | Box Score | Recap | Bradenton, FL |
| Big East Conference |
| 3/21/2008 | * | Connecticut | 7 | at | Louisville | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Notre Dame | 7 | at | Georgetown | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Pittsburgh | 6 | at | West Virginia | 12 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | South Florida | 14 | at | Cincinnati | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | St. John's | 2 | at | Rutgers | 0 | FINAL | Box Score | Recap | |
| Big South Conference |
| 3/21/2008 |
| Albany | 1 | at | #18 Coastal Carolina | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | VMI | 5 | at | High Point | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Columbia | 7 | at | Liberty | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Columbia | 11 | at | Liberty | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Hartford | 11 | at | North Carolina-Asheville | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Presbyterian | 4 | at | Charleston Southern | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Wagner | 6 | at | Winthrop | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Yale | 8 | at | Radford | 7 | FINAL | Box Score | Recap | |
| Big West Conference |
| 3/21/2008 |
| #7 Long Beach State | 13 | at | #17 UCLA | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Florida International | 2 | vs | #9 UC Irvine | 5 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 |
| Nevada-Las Vegas | 5 | at | #23 Cal State Fullerton | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Pacific | 10 | at | #27 Stanford | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Harvard | 4 | at | UC Riverside | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| St. Mary's | 9 | at | UC Santa Barbara | 3 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 3/21/2008 | * | George Mason | 6 | vs | Northeastern | 10 | FINAL | Box Score | Recap | Fairfax, VA (moved from NU, inclement weather) |
| 3/21/2008 | * | Georgia State | 9 | at | Virginia Commonwealth | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Hofstra | 2 | at | Towson | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | James Madison | 8 | at | Old Dominion | 7 | FINAL | Box Score | Recap | 11 innings |
| 3/21/2008 | * | William and Mary | 2 | at | North Carolina-Wilmington | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Lafayette | 12 | at | Delaware | 7 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Lafayette | 2 | at | Delaware | 15 | FINAL | Box Score | Recap | moved from 3/22, impending weather |
| Conference USA |
| 3/21/2008 | * | #13 Rice | 6 | at | Marshall | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #30 UCF | 4 | at | Southern Mississippi | 8 | FINAL | Box Score | Recap | 900th career win for USM's Corky Palmer |
| 3/21/2008 | * | Alabama-Birmingham | 5 | at | Memphis | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Houston | 14 | at | East Carolina | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Sacred Heart | 0 | at | Tulane | 8 | FINAL | Box Score | Recap | |
| Division I Independents |
| 3/21/2008 |
| Northern Colorado | 6 | at | #1 Arizona State | 3 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 |
| Chicago State | 6 | at | Centenary | 13 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Chicago State | 2 | at | Centenary | 8 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Cornell | 17 | vs | New Jersey Tech | 2 | FINAL | Box Score | Recap | Papa John's Challenge, West Palm Beach, FL |
| 3/21/2008 |
| Dallas Baptist | 19 | at | Oral Roberts | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Elizabeth City State | 8 | at | North Carolina Central | 1 | FINAL | Box Score | Recap | 7 innings (makeup of 3/20 game) |
| 3/21/2008 |
| Elizabeth City State | 13 | at | North Carolina Central | 10 | FINAL | Box Score | Recap | 7 innings (makeup of 3/20 game) |
| 3/21/2008 |
| Houston Baptist | 2 | at | Texas-Pan American | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Presbyterian | 4 | at | Charleston Southern | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Savannah State | 9 | at | Alabama A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Savannah State | 11 | at | Alabama A&M | 2 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Utah Valley State | 0 | vs | Portland | 2 | FINAL | Box Score | Recap | Seattle, WA |
| 3/21/2008 |
| Utah Valley State | 3 | at | Washington | 12 | FINAL | Box Score | Recap | |
| Horizon League |
| 3/21/2008 | * | Valparaiso | 6 | at | Wright State | 5 | FINAL | Box Score | Recap | Xenia, OH |
| 3/21/2008 | * | Valparaiso | 7 | at | Wright State | 8 | FINAL | Box Score | Recap | 10 innings (Xenia, OH) |
| 3/21/2008 | * | Wisconsin-Milwaukee |
| at | Illinois-Chicago |
| Postponed | | Recap | PPD, inclement weather |
| 3/21/2008 | * | Youngstown State | 4 | at | Butler | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Cleveland State |
| at | Case Western |
| Canceled | | | CCD |
| Ivy League |
| 3/21/2008 |
| Army | 14 | vs | Dartmouth | 7 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Columbia | 7 | at | Liberty | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Columbia | 11 | at | Liberty | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Cornell | 17 | vs | New Jersey Tech | 2 | FINAL | Box Score | Recap | Papa John's Challenge, West Palm Beach, FL |
| 3/21/2008 |
| Dartmouth | 19 | vs | Army | 18 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Harvard | 4 | at | UC Riverside | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Mount St. Mary's | 3 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Mount St. Mary's | 5 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Princeton | 3 | at | Navy | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Yale | 8 | at | Radford | 7 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 3/21/2008 | * | Manhattan | 20 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Manhattan | 1 | at | Rider | 4 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 3/21/2008 | * | Ball State |
| at | Akron |
| Postponed | | Recap | PPD to 3/22, field conditions |
| 3/21/2008 | * | Bowling Green State |
| at | Western Michigan |
| Postponed | | Recap | PPD to 3/22, snow |
| 3/21/2008 | * | Kent State |
| at | Eastern Michigan |
| Suspended | | Recap | Suspended to 3/22, snow (3-0 EMU, bottom 2) |
| 3/21/2008 | * | Toledo | 1 | at | Miami, Ohio | 8 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 3/21/2008 |
| Long Island | 4 | at | Delaware State | 20 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 3/21/2008 | * | #15 Wichita State |
| at | Illinois State |
| Postponed | | Recap | PPD to 3/22, field conditions |
| 3/21/2008 | * | Bradley | 8 | at | Evansville | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Creighton | 8 | at | Missouri State | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Indiana State | 2 | at | Southern Illinois | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Northern Iowa | 6 | vs | Northwestern | 0 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Northwestern | 1 | vs | Northern Iowa | 2 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| Mountain West Conference |
| 3/21/2008 |
| Nevada-Las Vegas | 5 | at | #23 Cal State Fullerton | 11 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Air Force | 5 | at | Brigham Young | 12 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | New Mexico | 7 | at | Texas Christian | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | San Diego State | 5 | at | Utah | 7 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 3/21/2008 |
| Central Connecticut State | 8 | vs | Illinois | 7 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Fairleigh Dickinson | 4 | at | San Francisco | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Illinois | 5 | vs | Central Connecticut State | 4 | FINAL | Box Score | Recap | 7 innings (Bradenton, FL) |
| 3/21/2008 |
| Long Island | 4 | at | Delaware State | 20 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Mount St. Mary's | 3 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Mount St. Mary's | 5 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Sacred Heart | 0 | at | Tulane | 8 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, travel problems |
| 3/21/2008 |
| Wagner | 6 | at | Winthrop | 10 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 3/21/2008 | * | Austin Peay State | 1 | at | Eastern Kentucky | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Austin Peay State | 7 | at | Eastern Kentucky | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Morehead State | 2 | at | Eastern Illinois | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Morehead State | 1 | at | Eastern Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 | * | Murray State | 3 | at | Jacksonville State | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Murray State | 1 | at | Jacksonville State | 2 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 | * | Tennessee Tech | 3 | at | Southeast Missouri State | 16 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Tennessee Tech | 8 | at | Southeast Missouri State | 3 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 | * | Tennessee-Martin | 3 | at | Samford | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Tennessee-Martin | 1 | at | Samford | 14 | FINAL | Box Score | Recap | 7 innings |
| Pac 10 Conference |
| 3/21/2008 |
| Northern Colorado | 6 | at | #1 Arizona State | 3 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 | * | #2 Arizona | 10 | at | Southern California | 2 | FINAL | Box Score | Recap | makeup of 3/20 game |
| 3/21/2008 | * | #2 Arizona | 0 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| #7 Long Beach State | 13 | at | #17 UCLA | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #24 California | 7 | at | Washington State | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| #29 Pepperdine | 3 | at | #25 Oregon State | 10 | FINAL | Box Score | Recap | Resumption of 3/20 game |
| 3/21/2008 |
| #29 Pepperdine | 7 | at | #25 Oregon State | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Pacific | 10 | at | #27 Stanford | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Utah Valley State | 3 | at | Washington | 12 | FINAL | Box Score | Recap | |
| Patriot League |
| 3/21/2008 |
| Army | 14 | vs | Dartmouth | 7 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Dartmouth | 19 | vs | Army | 18 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/21/2008 |
| Lafayette | 12 | at | Delaware | 7 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Lafayette | 2 | at | Delaware | 15 | FINAL | Box Score | Recap | moved from 3/22, impending weather |
| 3/21/2008 |
| Lehigh | 9 | at | Penn State | 18 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Princeton | 3 | at | Navy | 6 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 3/21/2008 | * | #6 Vanderbilt | 2 | at | Alabama | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Mississippi State | 1 | at | #8 South Carolina | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | #12 Kentucky | 0 | at | Auburn | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Florida | 4 | at | #14 Mississippi | 5 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Arkansas | 7 | at | Louisiana State | 8 | FINAL | Box Score | Recap | 11 innings |
| 3/21/2008 | * | Tennessee | 2 | at | Georgia | 6 | FINAL | Box Score | Recap | |
| Southern Conference |
| 3/21/2008 | * | College of Charleston | 31 | at | Davidson | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Elon | 9 | at | Wofford | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Furman | 11 | at | The Citadel | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | North Carolina-Greensboro | 9 | at | Appalachian State | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Western Carolina | 10 | at | Georgia Southern | 19 | FINAL | Box Score | Recap | |
| Southland Conference |
| 3/21/2008 | * | Nicholls State | 1 | at | McNeese State | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Northwestern State | 0 | at | Southeastern Louisiana | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Sam Houston State | 1 | at | Texas A&M-Corpus Christi | 4 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Stephen F. Austin | 4 | at | Lamar | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Texas-Arlington | 9 | at | Texas State | 10 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Texas-San Antonio | 5 | at | Central Arkansas | 8 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 3/21/2008 | * | Alcorn State | 3 | at | Mississippi Valley State | 14 | FINAL | Box Score | | 7 innings |
| 3/21/2008 | * | Alcorn State | 4 | at | Mississippi Valley State | 3 | FINAL | Box Score | | 7 innings |
| 3/21/2008 |
| Savannah State | 9 | at | Alabama A&M | 5 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Savannah State | 11 | at | Alabama A&M | 2 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Wiley | 8 | at | Arkansas-Pine Bluff | 10 | FINAL | Box Score | | 7 innings |
| 3/21/2008 |
| Wiley | 7 | at | Arkansas-Pine Bluff | 5 | FINAL | Box Score | | 7 innings |
| Summit League |
| 3/21/2008 |
| Chicago State | 6 | at | Centenary | 13 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Chicago State | 2 | at | Centenary | 8 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 |
| Dallas Baptist | 19 | at | Oral Roberts | 6 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| IUPU-Fort Wayne |
| at | Michigan |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| 3/21/2008 |
| Oakland |
| at | Michigan State |
| Postponed | | Recap | PPD to 3/22, snow |
| 3/21/2008 |
| South Dakota State | 1 | at | Minnesota | 3 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 3/21/2008 |
| Florida International | 2 | vs | #9 UC Irvine | 5 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/21/2008 | * | Louisiana-Lafayette | 12 | at | Arkansas-Little Rock | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Louisiana-Monroe | 3 | at | Arkansas State | 1 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Middle Tennessee State | 7 | at | Florida Atlantic | 13 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | South Alabama | 5 | at | New Orleans | 8 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Troy | 5 | at | Western Kentucky | 4 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 3/21/2008 |
| #29 Pepperdine | 3 | at | #25 Oregon State | 10 | FINAL | Box Score | Recap | Resumption of 3/20 game |
| 3/21/2008 |
| #29 Pepperdine | 7 | at | #25 Oregon State | 9 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Fairleigh Dickinson | 4 | at | San Francisco | 7 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Gonzaga | 4 | at | Cal State Sacramento | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| St. Mary's | 9 | at | UC Santa Barbara | 3 | FINAL | Box Score | Recap | |
| 3/21/2008 |
| Utah Valley State | 0 | vs | Portland | 2 | FINAL | Box Score | Recap | Seattle, WA |
| Western Athletic Conference |
| 3/21/2008 | * | Fresno State | 0 | at | Hawaii | 2 | FINAL | Box Score | Recap | |
| 3/21/2008 | * | Louisiana Tech | 3 | at | Nevada | 14 | FINAL | Box Score | Recap | 7 innings (mercy rule) |
| 3/21/2008 | * | San Jose State | 1 | at | New Mexico State | 12 | FINAL | Box Score | Recap | 7 innings |
| 3/21/2008 | * | San Jose State | 10 | at | New Mexico State | 8 | FINAL | Box Score | Recap | 10 innings |
| 3/21/2008 |
| Gonzaga | 4 | at | Cal State Sacramento | 3 | FINAL | Box Score | Recap | |