| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 3/22/2008 |
| Florida International | 5 | at | #1 Arizona State | 10 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 |
| Florida International | 4 | at | #1 Arizona State | 8 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 | * | #2 Arizona | 0 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #3 North Carolina | 14 | at | Maryland | 1 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Wake Forest |
| at | #4 Miami, Florida |
| Postponed | | Recap | PPD to 3/23, inclement weather |
| 3/22/2008 | * | #5 Florida State | 12 | at | Virginia Tech | 11 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #6 Vanderbilt | 7 | at | Alabama | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #17 UCLA | 2 | at | #7 Long Beach State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #17 UCLA | 3 | at | #7 Long Beach State | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Mississippi State | 1 | at | #8 South Carolina | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #9 UC Irvine | 9 | vs | Northern Colorado | 6 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 | * | #10 Texas | 4 | at | Texas Tech | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #16 Baylor | 0 | at | #11 Missouri | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #12 Kentucky | 5 | at | Auburn | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #13 Rice | 13 | at | Marshall | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Florida | 6 | at | #14 Mississippi | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #15 Wichita State | 12 | at | Illinois State | 1 | FINAL | Box Score | Recap | 7 innings, run rule (makeup of 3/21 game) |
| 3/22/2008 | * | #15 Wichita State | 6 | at | Illinois State | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Albany | 4 | at | #18 Coastal Carolina | 18 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #19 Texas A&M | 2 | at | #26 Oklahoma State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Boston College | 4 | at | #20 Virginia | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | North Carolina State | 2 | at | #21 Clemson | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Harvard | 2 | at | #22 San Diego | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Harvard | 2 | at | #22 San Diego | 18 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Nevada-Las Vegas | 3 | at | #23 Cal State Fullerton | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #24 California | 4 | at | Washington State | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 |
| #29 Pepperdine | 8 | at | #25 Oregon State | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #27 Stanford | 7 | at | Pacific | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Duke | 2 | at | #28 Georgia Tech | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #30 UCF | 15 | at | Southern Mississippi | 4 | FINAL | Box Score | Recap | |
| America East Conference |
| 3/22/2008 |
| Albany | 4 | at | #18 Coastal Carolina | 18 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Binghamton | 0 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Hartford | 9 | vs | Brown | 25 | FINAL | Box Score | Recap | Asheville, NC |
| 3/22/2008 |
| Hartford | 8 | at | North Carolina-Asheville | 33 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Maine |
| at | New York Tech |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Maine |
| at | New York Tech |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Stony Brook | 7 | at | Longwood | 6 | FINAL | Box Score | Recap | 12 innings |
| 3/22/2008 |
| Stony Brook | 3 | at | Longwood | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, field conditions |
| Atlantic 10 Conference |
| 3/22/2008 | * | LaSalle | 4 | at | Richmond | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Massachusetts | 2 | at | Duquesne | 5 | FINAL | Box Score | Recap | 7 innings (Greensburg, PA) |
| 3/22/2008 | * | St. Bonaventure | 7 | at | Fordham | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | St. Joseph's | 4 | at | George Washington | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | St. Louis | 9 | at | North Carolina-Charlotte | 10 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | Temple | 9 | at | Rhode Island | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Xavier | 9 | at | Dayton | 0 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 3/22/2008 | * | #3 North Carolina | 14 | at | Maryland | 1 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Wake Forest |
| at | #4 Miami, Florida |
| Postponed | | Recap | PPD to 3/23, inclement weather |
| 3/22/2008 | * | #5 Florida State | 12 | at | Virginia Tech | 11 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Boston College | 4 | at | #20 Virginia | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | North Carolina State | 2 | at | #21 Clemson | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Duke | 2 | at | #28 Georgia Tech | 4 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 3/22/2008 | * | East Tennessee State | 7 | at | Jacksonville | 2 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Mercer | 4 | at | Florida Gulf Coast | 16 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 | * | Mercer | 5 | at | Florida Gulf Coast | 6 | FINAL | Box Score | Recap | 14 innings |
| 3/22/2008 | * | South Carolina-Upstate | 4 | at | North Florida | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | South Carolina-Upstate | 4 | at | North Florida | 11 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 3/22/2008 |
| Grand View |
| at | Iowa |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| IUPU-Fort Wayne | 2 | at | Indiana | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Kansas |
| vs | Northwestern |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| 3/22/2008 |
| Kansas |
| vs | Northwestern |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| 3/22/2008 |
| Lehigh |
| at | Penn State |
| Canceled | | Recap | CCD, snow |
| 3/22/2008 |
| Oakland |
| at | Michigan State |
| Canceled | | Recap | CCD, field conditions (makeup of 3/21 game) |
| 3/22/2008 |
| Oakland |
| at | Michigan State |
| Postponed | | Recap | PPD to 3/22, field conditions |
| 3/22/2008 |
| South Dakota State | 4 | at | Minnesota | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 |
| Western Illinois | 0 | at | Purdue | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Western Illinois | 0 | at | Purdue | 8 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 3/22/2008 | * | #10 Texas | 4 | at | Texas Tech | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #16 Baylor | 0 | at | #11 Missouri | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #19 Texas A&M | 2 | at | #26 Oklahoma State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Oklahoma | 3 | at | Nebraska | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Binghamton | 0 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Kansas |
| vs | Northwestern |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| 3/22/2008 |
| Kansas |
| vs | Northwestern |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| Big East Conference |
| 3/22/2008 | * | Connecticut | 12 | at | Louisville | 8 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | Notre Dame | 6 | at | Georgetown | 0 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Pittsburgh | 1 | at | West Virginia | 8 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | South Florida | 1 | at | Cincinnati | 6 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 | * | South Florida | 4 | at | Cincinnati | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | St. John's | 12 | at | Rutgers | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Villanova | 0 | at | Seton Hall | 13 | FINAL | Box Score | Recap | |
| Big South Conference |
| 3/22/2008 |
| Albany | 4 | at | #18 Coastal Carolina | 18 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | VMI | 5 | at | High Point | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | VMI | 3 | at | High Point | 0 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Columbia | 2 | at | Liberty | 12 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Hartford | 8 | at | North Carolina-Asheville | 33 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Presbyterian | 5 | at | Charleston Southern | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Presbyterian | 0 | at | Charleston Southern | 12 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Wagner | 5 | at | Winthrop | 2 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Yale | 1 | at | Radford | 2 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Yale | 12 | at | Radford | 13 | FINAL | Box Score | Recap | 7 innings |
| Big West Conference |
| 3/22/2008 |
| #17 UCLA | 2 | at | #7 Long Beach State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #17 UCLA | 3 | at | #7 Long Beach State | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #9 UC Irvine | 9 | vs | Northern Colorado | 6 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 |
| Nevada-Las Vegas | 3 | at | #23 Cal State Fullerton | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #27 Stanford | 7 | at | Pacific | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Loyola Marymount | 9 | at | Cal State Northridge | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Loyola Marymount | 3 | at | Cal State Northridge | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Santa Clara | 11 | at | Cal Poly | 8 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Santa Clara | 4 | at | Cal Poly | 13 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| St. Mary's | 4 | at | UC Santa Barbara | 11 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| St. Mary's | 0 | at | UC Santa Barbara | 6 | FINAL | Box Score | Recap | 7 innings |
| Colonial Athletic Association |
| 3/22/2008 | * | George Mason | 5 | at | Northeastern | 4 | FINAL | Box Score | Recap | moved from NU, weather |
| 3/22/2008 | * | Georgia State | 5 | at | Virginia Commonwealth | 2 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Hofstra | 4 | at | Towson | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | James Madison | 10 | at | Old Dominion | 19 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | William and Mary | 5 | at | North Carolina-Wilmington | 16 | FINAL | Box Score | Recap | |
| Conference USA |
| 3/22/2008 | * | #13 Rice | 13 | at | Marshall | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #30 UCF | 15 | at | Southern Mississippi | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Alabama-Birmingham | 2 | at | Memphis | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Houston | 4 | at | East Carolina | 15 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Sacred Heart | 2 | at | Tulane | 5 | FINAL | Box Score | Recap | |
| Division I Independents |
| 3/22/2008 |
| #9 UC Irvine | 9 | vs | Northern Colorado | 6 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 |
| Canisius | 1 | at | LeMoyne | 3 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Canisius | 5 | at | LeMoyne | 1 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Chicago State | 8 | at | Centenary | 16 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Chicago State | 1 | at | Centenary | 4 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Chowan | 10 | at | North Carolina Central | 1 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Chowan | 9 | at | North Carolina Central | 0 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Dallas Baptist | 4 | at | Oral Roberts | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Maine |
| at | New York Tech |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Maine |
| at | New York Tech |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Presbyterian | 5 | at | Charleston Southern | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Presbyterian | 0 | at | Charleston Southern | 12 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Savannah State | 10 | at | Alabama A&M | 12 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Stony Brook | 7 | at | Longwood | 6 | FINAL | Box Score | Recap | 12 innings |
| 3/22/2008 |
| Stony Brook | 3 | at | Longwood | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Utah Valley State | 0 | at | Washington | 5 | FINAL | Box Score | Recap | |
| Horizon League |
| 3/22/2008 | * | Valparaiso |
| at | Wright State |
| Postponed | | Recap | PPD, inclement weather (Xenia, OH) |
| 3/22/2008 | * | Wisconsin-Milwaukee | 8 | at | Illinois-Chicago | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Wisconsin-Milwaukee |
| at | Illinois-Chicago |
| Postponed | | Recap | PPD to 3/23 |
| 3/22/2008 | * | Youngstown State | 1 | at | Butler | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Youngstown State | 2 | at | Butler | 1 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Case Western |
| at | Cleveland State |
| Canceled | | | CCD, field conditions |
| Ivy League |
| 3/22/2008 |
| Harvard | 2 | at | #22 San Diego | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Harvard | 2 | at | #22 San Diego | 18 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Columbia | 2 | at | Liberty | 12 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Dartmouth |
| vs | Northern Iowa |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| 3/22/2008 |
| Hartford | 9 | vs | Brown | 25 | FINAL | Box Score | Recap | Asheville, NC |
| 3/22/2008 |
| Mount St. Mary's | 6 | at | Pennsylvania | 7 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Mount St. Mary's | 4 | at | Pennsylvania | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Princeton | 1 | at | Navy | 2 | FINAL | Box Score | Recap | 8 innings |
| 3/22/2008 |
| Princeton | 20 | at | Navy | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Southeastern (FL) | 8 | vs | Cornell | 11 | FINAL | Box Score | Recap | Boynton Beach, FL |
| 3/22/2008 |
| Yale | 1 | at | Radford | 2 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Yale | 12 | at | Radford | 13 | FINAL | Box Score | Recap | 7 innings |
| Metro Atlantic Athletic Conference |
| 3/22/2008 | * | Iona | 5 | at | St. Peter's | 2 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Iona | 5 | at | St. Peter's | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Manhattan | 7 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Marist | 0 | at | Fairfield | 1 | FINAL | | Recap | |
| 3/22/2008 | * | Marist | 3 | at | Fairfield | 0 | FINAL | | Recap | |
| 3/22/2008 | * | Niagara | 12 | at | Siena | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Niagara | 4 | at | Siena | 7 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Canisius | 1 | at | LeMoyne | 3 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Canisius | 5 | at | LeMoyne | 1 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 3/22/2008 | * | Ball State |
| at | Akron |
| Canceled | | Recap | CCD, field conditions (makeup of 3/21 game) |
| 3/22/2008 | * | Ball State |
| at | Akron |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 | * | Bowling Green State |
| at | Western Michigan |
| Canceled | | Recap | CCD, field conditions (makeup of 3/21 game) |
| 3/22/2008 | * | Bowling Green State |
| at | Western Michigan |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 | * | Kent State |
| at | Eastern Michigan |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 | * | Kent State |
| at | Eastern Michigan |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 | * | Northern Illinois | 10 | at | Buffalo | 3 | FINAL | Box Score | Recap | Olean, NY |
| 3/22/2008 | * | Northern Illinois | 17 | at | Buffalo | 1 | FINAL | Box Score | Recap | Olean, NY |
| 3/22/2008 | * | Ohio | 13 | at | Central Michigan | 2 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Toledo | 6 | at | Miami, Ohio | 2 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 3/22/2008 | * | Bethune-Cookman | 10 | at | Florida A&M | 0 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Bethune-Cookman | 9 | at | Florida A&M | 1 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 | * | Maryland-Eastern Shore | 11 | at | Coppin State | 7 | FINAL | Box Score | Recap | Severn, MD |
| 3/22/2008 | * | Maryland-Eastern Shore |
| at | Coppin State |
| Postponed | | Recap | PPD to 3/23, scheduling conflict |
| 3/22/2008 | * | Norfolk State | 5 | at | North Carolina A&T | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Norfolk State | 7 | at | North Carolina A&T | 10 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Long Island | 13 | at | Delaware State | 4 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 3/22/2008 | * | #15 Wichita State | 12 | at | Illinois State | 1 | FINAL | Box Score | Recap | 7 innings, run rule (makeup of 3/21 game) |
| 3/22/2008 | * | #15 Wichita State | 6 | at | Illinois State | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Bradley | 9 | at | Evansville | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Creighton | 1 | at | Missouri State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Indiana State | 3 | at | Southern Illinois | 11 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Dartmouth |
| vs | Northern Iowa |
| Canceled | | Recap | CCD, rain (Bradenton, FL) |
| Mountain West Conference |
| 3/22/2008 |
| Nevada-Las Vegas | 3 | at | #23 Cal State Fullerton | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Air Force | 5 | at | Brigham Young | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | New Mexico | 5 | at | Texas Christian | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | San Diego State | 9 | at | Utah | 3 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 3/22/2008 |
| Army | 12 | vs | Central Connecticut State | 1 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/22/2008 |
| Bucknell | 4 | vs | Long Island | 6 | FINAL | Box Score | Recap | Dover, DE |
| 3/22/2008 |
| Fairleigh Dickinson | 2 | at | San Francisco | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Fairleigh Dickinson | 1 | at | San Francisco | 11 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Long Island | 13 | at | Delaware State | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Mount St. Mary's | 6 | at | Pennsylvania | 7 | FINAL | Box Score | Recap | 7 innings |
| 3/22/2008 |
| Mount St. Mary's | 4 | at | Pennsylvania | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Quinnipiac | 7 | at | Holy Cross | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Sacred Heart | 2 | at | Tulane | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Vermont |
| at | Monmouth |
| Canceled | | Recap | CCD, field conditions |
| 3/22/2008 |
| Wagner | 5 | at | Winthrop | 2 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 3/22/2008 | * | Austin Peay State | 3 | at | Eastern Kentucky | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Morehead State | 2 | at | Eastern Illinois | 16 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Murray State | 8 | at | Jacksonville State | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Tennessee Tech | 3 | at | Southeast Missouri State | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Tennessee-Martin | 5 | at | Samford | 12 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 3/22/2008 |
| Florida International | 5 | at | #1 Arizona State | 10 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 |
| Florida International | 4 | at | #1 Arizona State | 8 | FINAL | Box Score | Recap | Bob Schaefer Memorial Tournament, Tempe, AZ |
| 3/22/2008 | * | #2 Arizona | 0 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #17 UCLA | 2 | at | #7 Long Beach State | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #17 UCLA | 3 | at | #7 Long Beach State | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #24 California | 4 | at | Washington State | 5 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 |
| #29 Pepperdine | 8 | at | #25 Oregon State | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| #27 Stanford | 7 | at | Pacific | 3 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Portland | 5 | at | Washington | 6 | FINAL | Box Score | Recap | Seattle, WA |
| 3/22/2008 |
| Utah Valley State | 0 | at | Washington | 5 | FINAL | Box Score | Recap | |
| Patriot League |
| 3/22/2008 |
| Army | 12 | vs | Central Connecticut State | 1 | FINAL | Box Score | Recap | Bradenton, FL |
| 3/22/2008 |
| Bucknell | 4 | vs | Long Island | 6 | FINAL | Box Score | Recap | Dover, DE |
| 3/22/2008 |
| Lehigh |
| at | Penn State |
| Canceled | | Recap | CCD, snow |
| 3/22/2008 |
| Princeton | 1 | at | Navy | 2 | FINAL | Box Score | Recap | 8 innings |
| 3/22/2008 |
| Princeton | 20 | at | Navy | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 |
| Quinnipiac | 7 | at | Holy Cross | 3 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 3/22/2008 | * | #6 Vanderbilt | 7 | at | Alabama | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Mississippi State | 1 | at | #8 South Carolina | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | #12 Kentucky | 5 | at | Auburn | 7 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Florida | 6 | at | #14 Mississippi | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Arkansas | 14 | at | Louisiana State | 13 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | Tennessee | 2 | at | Georgia | 3 | FINAL | Box Score | Recap | |
| Southern Conference |
| 3/22/2008 | * | College of Charleston | 13 | at | Davidson | 4 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Elon | 12 | at | Wofford | 5 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Elon | 7 | at | Wofford | 8 | FINAL | Box Score | Recap | 11 innings |
| 3/22/2008 | * | Furman | 1 | at | The Citadel | 10 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | North Carolina-Greensboro | 12 | at | Appalachian State | 8 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Western Carolina | 12 | at | Georgia Southern | 13 | FINAL | Box Score | Recap | |
| Southland Conference |
| 3/22/2008 | * | Nicholls State | 5 | at | McNeese State | 8 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Northwestern State | 9 | at | Southeastern Louisiana | 8 | FINAL | Box Score | Recap | 10 innings |
| 3/22/2008 | * | Sam Houston State | 11 | at | Texas A&M-Corpus Christi | 9 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Stephen F. Austin | 5 | at | Lamar | 6 | FINAL | Box Score | Recap | |
| 3/22/2008 | * | Texas-Arlington | |