| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 3/25/2008 |
| Bethune-Cookman | 5 | at | #2 Miami, Florida | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Davidson | 6 | at | #3 North Carolina | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Stetson | 2 | at | #4 Florida State | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #5 Long Beach State | 5 | at | Pepperdine | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #6 Arizona | 2 | at | #22 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Furman | 4 | at | #7 South Carolina | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #8 Missouri | 17 | at | Minnesota | 8 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Harvard | 2 | at | #9 UC Irvine | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Belmont | 3 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #12 Rice | 13 | at | Texas State | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Binghamton | 2 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Xavier | 2 | at | #14 Kentucky | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Virginia Commonwealth | 3 | at | #15 Virginia | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #21 Cal State Fullerton | 6 | at | #16 San Diego | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #17 Mississippi | 2 | vs | Southern Mississippi | 3 | FINAL | Box Score | Recap | 10 innings (800th collegiate win for USM's Corky Palmer); Pearl, MS |
| 3/25/2008 |
| #18 Coastal Carolina | 6 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Elon | 4 | at | #19 Clemson | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #20 Texas A&M | 5 | vs | Texas-San Antonio | 4 | FINAL | Box Score | Recap | San Antonio, TX |
| 3/25/2008 |
| Houston Baptist | 4 | at | #23 Baylor | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #24 UCLA | 3 | at | San Diego State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #25 Oregon State | 17 | at | Brigham Young | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Jacksonville | 6 | at | #26 Florida | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Georgia State | 1 | at | #27 Georgia Tech | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #29 Stanford | 3 | at | Cal State Sacramento | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Northern Colorado | 0 | at | #30 Nebraska | 10 | FINAL | Box Score | Recap | |
| America East Conference |
| 3/25/2008 |
| Binghamton | 2 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Albany | 7 | at | North Carolina-Greensboro | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Hartford | 1 | at | Boston College | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Mount St. Mary's | 5 | at | Maryland-Baltimore County | 9 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 3/25/2008 |
| Xavier | 2 | at | #14 Kentucky | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Duquesne | 6 | at | Akron | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Findlay | 3 | at | Dayton | 13 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Fordham | 4 | at | Marist | 15 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| George Washington | 11 | at | Towson | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Illinois State | 8 | at | St. Louis | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| LaSalle | 8 | at | Temple | 10 | FINAL | Box Score | Recap | Liberty Bell Classic, Philadelphia, PA |
| 3/25/2008 |
| Northeastern | 8 | at | Rhode Island | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Radford | 8 | at | North Carolina-Charlotte | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Sacred Heart | 3 | at | Massachusetts | 15 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| St. Joseph's | 2 | at | Delaware | 17 | FINAL | Box Score | Recap | Liberty Bell Classic |
| Atlantic Coast Conference |
| 3/25/2008 |
| Bethune-Cookman | 5 | at | #2 Miami, Florida | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Davidson | 6 | at | #3 North Carolina | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Stetson | 2 | at | #4 Florida State | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Virginia Commonwealth | 3 | at | #15 Virginia | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Elon | 4 | at | #19 Clemson | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Georgia State | 1 | at | #27 Georgia Tech | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Brown | 6 | at | Duke | 7 | FINAL | Box Score | Recap | 10 innings |
| 3/25/2008 |
| Hartford | 1 | at | Boston College | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Marshall | 5 | at | North Carolina State | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Maryland | 6 | at | George Mason | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| North Carolina-Asheville | 12 | at | Wake Forest | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Virginia Tech | 18 | at | James Madison | 11 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 3/25/2008 |
| Stetson | 2 | at | #4 Florida State | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Belmont | 3 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Jacksonville | 6 | at | #26 Florida | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Campbell | 8 | at | North Carolina Central | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| East Tennessee State | 11 | at | Western Carolina | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Georgia | 12 | at | Kennesaw State | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Mercer | 4 | at | Auburn | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Murray State | 3 | at | Lipscomb | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| North Florida | 8 | at | UCF | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Carolina-Upstate | 4 | at | Tennessee | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Florida | 3 | at | Florida Gulf Coast | 2 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 3/25/2008 |
| #8 Missouri | 17 | at | Minnesota | 8 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Bowling Green State |
| at | Michigan |
| Postponed | | Recap | PPD, inclement weather |
| 3/25/2008 |
| Illinois |
| at | Indiana State |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| 3/25/2008 |
| Western Illinois | 4 | at | Iowa | 7 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 3/25/2008 |
| #6 Arizona | 2 | at | #22 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #8 Missouri | 17 | at | Minnesota | 8 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #20 Texas A&M | 5 | vs | Texas-San Antonio | 4 | FINAL | Box Score | Recap | San Antonio, TX |
| 3/25/2008 |
| Houston Baptist | 4 | at | #23 Baylor | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Northern Colorado | 0 | at | #30 Nebraska | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Chicago State | 4 | at | Kansas | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Texas-Arlington | 5 | at | Oklahoma | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| UC Riverside | 8 | at | Texas Tech | 6 | FINAL | Box Score | Recap | |
| Big East Conference |
| 3/25/2008 |
| Ball State | 4 | at | Notre Dame | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Columbia | 5 | at | St. John's | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Connecticut | 10 | at | Holy Cross | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Louisville | 19 | at | Eastern Kentucky | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Morehead State | 5 | at | West Virginia | 10 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Morehead State | 6 | at | West Virginia | 16 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| New Jersey Tech | 1 | at | Seton Hall | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Rider | 3 | at | Rutgers | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Florida | 3 | at | Florida Gulf Coast | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Toledo | 3 | at | Cincinnati | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Villanova | 2 | at | Lehigh | 3 | FINAL | Box Score | Recap | Liberty Bell Classic, Bethlehem, PA |
| Big South Conference |
| 3/25/2008 |
| #18 Coastal Carolina | 6 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| High Point | 3 | at | Appalachian State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| North Carolina-Asheville | 12 | at | Wake Forest | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Radford | 8 | at | North Carolina-Charlotte | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| William and Mary | 8 | at | VMI | 9 | FINAL | Box Score | Recap | |
| Big West Conference |
| 3/25/2008 |
| #5 Long Beach State | 5 | at | Pepperdine | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Harvard | 2 | at | #9 UC Irvine | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #21 Cal State Fullerton | 6 | at | #16 San Diego | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Cal Poly | 9 | at | Fresno State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| UC Davis | 7 | at | St. Mary's | 6 | FINAL | Box Score | Recap | 10 innings |
| 3/25/2008 |
| UC Riverside | 8 | at | Texas Tech | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Westmont | 3 | at | UC Santa Barbara | 6 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 3/25/2008 |
| Virginia Commonwealth | 3 | at | #15 Virginia | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Georgia State | 1 | at | #27 Georgia Tech | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| George Washington | 11 | at | Towson | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Hofstra | 6 | at | Siena | 3 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Hofstra | 1 | at | Siena | 9 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Maryland | 6 | at | George Mason | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Northeastern | 8 | at | Rhode Island | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Old Dominion | 8 | at | Longwood | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| St. Joseph's | 2 | at | Delaware | 17 | FINAL | Box Score | Recap | Liberty Bell Classic |
| 3/25/2008 |
| Virginia Tech | 18 | at | James Madison | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| William and Mary | 8 | at | VMI | 9 | FINAL | Box Score | Recap | |
| Conference USA |
| 3/25/2008 |
| #12 Rice | 13 | at | Texas State | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #17 Mississippi | 2 | vs | Southern Mississippi | 3 | FINAL | Box Score | Recap | 10 innings (800th collegiate win for USM's Corky Palmer); Pearl, MS |
| 3/25/2008 |
| Austin Peay State | 4 | vs | Memphis | 2 | FINAL | Box Score | Recap | Jackson, TN |
| 3/25/2008 |
| Houston | 11 | at | McNeese State | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Marshall | 5 | at | North Carolina State | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| North Florida | 8 | at | UCF | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Troy | 5 | at | Alabama-Birmingham | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Tulane | 11 | at | Southeastern Louisiana | 12 | FINAL | Box Score | Recap | |
| Division I Independents |
| 3/25/2008 |
| Northern Colorado | 0 | at | #30 Nebraska | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Air Force | 8 | at | Savannah State | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Buffalo | 9 | at | LeMoyne | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Campbell | 8 | at | North Carolina Central | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Chicago State | 4 | at | Kansas | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Hawaii-Hilo | 6 | at | Washington | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| New Jersey Tech | 1 | at | Seton Hall | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Old Dominion | 8 | at | Longwood | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Presbyterian | 8 | at | Wofford | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Sam Houston State | 8 | at | Dallas Baptist | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Texas-Pan American | 3 | at | Lamar | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Texas-Pan American | 1 | at | Lamar | 11 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Utah | 12 | at | Utah Valley State | 6 | FINAL | Box Score | Recap | |
| Horizon League |
| 3/25/2008 |
| Cedarville | 1 | at | Wright State | 17 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Indiana (PA) | 4 | at | Youngstown State | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| IUPU-Fort Wayne | 4 | at | Butler | 5 | FINAL | Box Score | Recap | 10 innings (makeup of 3/19 game) |
| 3/25/2008 |
| Niagara |
| at | Cleveland State |
| Canceled | | Recap | CCD, inclement weather |
| 3/25/2008 |
| St. Francis (IL) | 8 | at | Illinois-Chicago | 12 | FINAL | Box Score | Recap | |
| Ivy League |
| 3/25/2008 |
| Harvard | 2 | at | #9 UC Irvine | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Brown | 6 | at | Duke | 7 | FINAL | Box Score | Recap | 10 innings |
| 3/25/2008 |
| Columbia | 5 | at | St. John's | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Lafayette | 6 | at | Pennsylvania | 5 | FINAL | Box Score | Recap | Liberty Bell Classic, Easton, PA |
| Metro Atlantic Athletic Conference |
| 3/25/2008 |
| Canisius | 21 | at | Delaware State | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Fordham | 4 | at | Marist | 15 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Hofstra | 6 | at | Siena | 3 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Hofstra | 1 | at | Siena | 9 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Manhattan | 5 | at | Long Island | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Niagara |
| at | Cleveland State |
| Canceled | | Recap | CCD, inclement weather |
| 3/25/2008 |
| Rider | 3 | at | Rutgers | 4 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 3/25/2008 |
| Ball State | 4 | at | Notre Dame | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Bowling Green State |
| at | Michigan |
| Postponed | | Recap | PPD, inclement weather |
| 3/25/2008 |
| Bradley | 5 | at | Northern Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Bradley | 6 | at | Northern Illinois | 11 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Buffalo | 9 | at | LeMoyne | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Duquesne | 6 | at | Akron | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Grand Valley State |
| at | Western Michigan |
| Postponed | | Recap | PPD, field conditions |
| 3/25/2008 |
| Malone | 4 | at | Kent State | 16 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Rio Grande | 0 | at | Ohio | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Toledo | 3 | at | Cincinnati | 7 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 3/25/2008 |
| Bethune-Cookman | 5 | at | #2 Miami, Florida | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Alabama State | 11 | at | Florida A&M | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Canisius | 21 | at | Delaware State | 12 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 3/25/2008 |
| Binghamton | 2 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Bradley | 5 | at | Northern Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Bradley | 6 | at | Northern Illinois | 11 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Illinois |
| at | Indiana State |
| Postponed | | Recap | PPD to 3/26, inclement weather |
| 3/25/2008 |
| Illinois State | 8 | at | St. Louis | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Missouri State | 2 | at | Southeast Missouri State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Dakota State | 8 | at | Creighton | 9 | FINAL | Box Score | Recap | 11 innings |
| 3/25/2008 |
| Southern Illinois | 3 | at | Eastern Illinois | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Western Kentucky | 10 | at | Evansville | 1 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 3/25/2008 |
| #24 UCLA | 3 | at | San Diego State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #25 Oregon State | 17 | at | Brigham Young | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Air Force | 8 | at | Savannah State | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Nevada | 4 | at | Nevada-Las Vegas | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| New Mexico State | 15 | at | New Mexico | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Texas A&M-Corpus Christi | 0 | at | Texas Christian | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Texas A&M-Corpus Christi | 1 | at | Texas Christian | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Utah | 12 | at | Utah Valley State | 6 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 3/25/2008 |
| Manhattan | 5 | at | Long Island | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Mount St. Mary's | 5 | at | Maryland-Baltimore County | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Quinnipiac | 5 | at | Army | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Sacred Heart | 3 | at | Massachusetts | 15 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 3/25/2008 |
| Arkansas State | 12 | at | Tennessee-Martin | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Austin Peay State | 4 | vs | Memphis | 2 | FINAL | Box Score | Recap | Jackson, TN |
| 3/25/2008 |
| Jacksonville State | 6 | at | Alabama | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Louisville | 19 | at | Eastern Kentucky | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Missouri State | 2 | at | Southeast Missouri State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Morehead State | 5 | at | West Virginia | 10 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Morehead State | 6 | at | West Virginia | 16 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Murray State | 3 | at | Lipscomb | 4 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Southern Illinois | 3 | at | Eastern Illinois | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Tennessee Tech | 15 | at | Middle Tennessee State | 11 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 3/25/2008 |
| #6 Arizona | 2 | at | #22 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #24 UCLA | 3 | at | San Diego State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #25 Oregon State | 17 | at | Brigham Young | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #29 Stanford | 3 | at | Cal State Sacramento | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| California | 5 | at | Santa Clara | 7 | FINAL | Box Score | Recap | 10 innings |
| 3/25/2008 |
| Gonzaga | 2 | at | Washington State | 6 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Hawaii-Hilo | 6 | at | Washington | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Loyola Marymount | 8 | at | Southern California | 2 | FINAL | Box Score | Recap | |
| Patriot League |
| 3/25/2008 |
| Clarion | 3 | at | Bucknell | 15 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Clarion | 1 | at | Bucknell | 19 | FINAL | Box Score | Recap | 7 innings |
| 3/25/2008 |
| Connecticut | 10 | at | Holy Cross | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Lafayette | 6 | at | Pennsylvania | 5 | FINAL | Box Score | Recap | Liberty Bell Classic, Easton, PA |
| 3/25/2008 |
| Quinnipiac | 5 | at | Army | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Villanova | 2 | at | Lehigh | 3 | FINAL | Box Score | Recap | Liberty Bell Classic, Bethlehem, PA |
| Southeastern Conference |
| 3/25/2008 |
| Furman | 4 | at | #7 South Carolina | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Belmont | 3 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Xavier | 2 | at | #14 Kentucky | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #17 Mississippi | 2 | vs | Southern Mississippi | 3 | FINAL | Box Score | Recap | 10 innings (800th collegiate win for USM's Corky Palmer); Pearl, MS |
| 3/25/2008 |
| Jacksonville | 6 | at | #26 Florida | 11 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Centenary | 0 | at | Arkansas | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Georgia | 12 | at | Kennesaw State | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Jacksonville State | 6 | at | Alabama | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Mercer | 4 | at | Auburn | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Northwestern State | 3 | at | Louisiana State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Alabama | 6 | at | Mississippi State | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| South Carolina-Upstate | 4 | at | Tennessee | 9 | FINAL | Box Score | Recap | |
| Southern Conference |
| 3/25/2008 |
| Davidson | 6 | at | #3 North Carolina | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Furman | 4 | at | #7 South Carolina | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #18 Coastal Carolina | 6 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Elon | 4 | at | #19 Clemson | 5 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Albany | 7 | at | North Carolina-Greensboro | 9 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| East Tennessee State | 11 | at | Western Carolina | 12 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| High Point | 3 | at | Appalachian State | 10 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Presbyterian | 8 | at | Wofford | 7 | FINAL | Box Score | Recap | |
| Southland Conference |
| 3/25/2008 |
| #12 Rice | 13 | at | Texas State | 3 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| #20 Texas A&M | 5 | vs | Texas-San Antonio | 4 | FINAL | Box Score | Recap | San Antonio, TX |
| 3/25/2008 |
| Central Arkansas | 6 | at | Arkansas-Little Rock | 2 | FINAL | Box Score | Recap | |
| 3/25/2008 |
| Grambling State | 5 | vs | Nicholls State | 8 | FINAL | Box Score | Recap | Pineville, LA |
| 3/25/2008 |
| Houston | 11 | at | McNeese State | 1 | FINAL |