| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/1/2008 |
| Wofford | 3 | at | #1 Arizona State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Florida Atlantic | 7 | at | #2 Miami, Florida | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #25 Florida | 2 | vs | #3 Florida State | 10 | FINAL | Box Score | Recap | Jacksonville, FL |
| 4/1/2008 |
| North Carolina-Greensboro | 1 | at | #4 North Carolina | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Southeast Missouri State | 12 | at | #6 Vanderbilt | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #7 South Carolina | 7 | at | The Citadel | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #8 Wichita State | 7 | at | Kansas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #9 Long Beach State | 6 | at | Fresno State | 7 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Western Illinois | 5 | at | #10 Missouri | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Towson | 8 | at | #12 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #15 Rice | 7 | at | #13 Texas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Stephen F. Austin | 1 | at | #16 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #17 Clemson | 3 | at | Georgia | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #19 Cal State Fullerton | 8 | at | Loyola Marymount | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #20 California | 1 | at | San Francisco | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Elon |
| at | #21 Coastal Carolina |
| Postponed | | Recap | PPD, rain |
| 4/1/2008 |
| #22 Nebraska |
| at | Creighton |
| Postponed | | Recap | PPD to 4/23, cold |
| 4/1/2008 |
| East Tennessee State | 6 | at | #24 Georgia Tech | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #27 Mississippi |
| at | Memphis |
| Postponed | | Recap | PPD, inclement weather |
| 4/1/2008 |
| San Diego State | 2 | at | #28 UCLA | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #29 Baylor | 2 | at | Texas Christian | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Wake Forest | 1 | at | #30 North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/1/2008 |
| Connecticut | 12 | at | Hartford | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Maryland-Baltimore County | 14 | at | George Washington | 4 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/1/2008 |
| Fordham | 5 | at | New York Tech | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Holy Cross | 9 | at | Massachusetts | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Indiana State |
| at | St. Louis |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| LaSalle | 9 | vs | Villanova | 10 | FINAL | Box Score | Recap | Liberty Bell Classic |
| 4/1/2008 |
| Lehigh | 17 | at | Temple | 15 | FINAL | Box Score | Recap | Liberty Bell Classic |
| 4/1/2008 |
| Marshall | 12 | at | Dayton | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Maryland-Baltimore County | 14 | at | George Washington | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Ohio | 4 | at | Duquesne | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Rhode Island |
| at | Central Connecticut State |
| Postponed | | Recap | PPD, field conditions |
| 4/1/2008 |
| Richmond | 5 | at | VMI | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| St. Bonaventure |
| at | LeMoyne |
| Postponed | | Recap | PPD, weather and field conditions |
| 4/1/2008 |
| St. Joseph's |
| at | Pennsylvania |
| Postponed | | Recap | PPD to 4/2, inclement weather (Liberty Bell Classic) |
| 4/1/2008 |
| Wright State | 12 | at | Xavier | 11 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/1/2008 |
| Florida Atlantic | 7 | at | #2 Miami, Florida | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #25 Florida | 2 | vs | #3 Florida State | 10 | FINAL | Box Score | Recap | Jacksonville, FL |
| 4/1/2008 |
| North Carolina-Greensboro | 1 | at | #4 North Carolina | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Towson | 8 | at | #12 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #17 Clemson | 3 | at | Georgia | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| East Tennessee State | 6 | at | #24 Georgia Tech | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Wake Forest | 1 | at | #30 North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Boston College | 8 | at | Northeastern | 7 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Navy | 6 | at | Maryland | 13 | FINAL | Box Score | Recap | 400th career win for UM's Terry Rupp |
| 4/1/2008 |
| North Carolina State | 4 | at | East Carolina | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Radford | 5 | at | Virginia Tech | 9 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/1/2008 |
| East Tennessee State | 6 | at | #24 Georgia Tech | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Alabama State | 3 | at | Kennesaw State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Bethune-Cookman | 4 | at | Stetson | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Florida A&M | 3 | at | Jacksonville | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Florida Gulf Coast | 13 | at | Florida International | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Georgia Southern | 3 | at | North Florida | 1 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Middle Tennessee State | 6 | at | Lipscomb | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| North Carolina A&T | 6 | at | South Carolina-Upstate | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| North Carolina Central | 1 | at | Campbell | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Samford | 10 | at | Mercer | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Western Carolina | 13 | at | Gardner-Webb | 6 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/1/2008 |
| Illinois | 5 | vs | Southern Illinois | 2 | FINAL | Box Score | Recap | Marion, IL |
| Big 12 Conference |
| 4/1/2008 |
| #8 Wichita State | 7 | at | Kansas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Western Illinois | 5 | at | #10 Missouri | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #15 Rice | 7 | at | #13 Texas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Stephen F. Austin | 1 | at | #16 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #22 Nebraska |
| at | Creighton |
| Postponed | | Recap | PPD to 4/23, cold |
| 4/1/2008 |
| #29 Baylor | 2 | at | Texas Christian | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Central Arkansas | 0 | at | Kansas State | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Dallas Baptist | 4 | at | Oklahoma | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Texas A&M-Corpus Christi | 1 | at | Texas Tech | 6 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/1/2008 |
| Connecticut | 12 | at | Hartford | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Georgetown | 12 | at | Coppin State | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| LaSalle | 9 | vs | Villanova | 10 | FINAL | Box Score | Recap | Liberty Bell Classic |
| 4/1/2008 |
| Louisville | 5 | at | Western Kentucky | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Maryland-Eastern Shore | 7 | at | West Virginia | 23 | FINAL | Box Score | Recap | 7 innings |
| 4/1/2008 |
| Maryland-Eastern Shore | 1 | at | West Virginia | 18 | FINAL | Box Score | Recap | 7 innings (400th career win for WV's Greg Van Zant) |
| 4/1/2008 |
| Miami, Ohio | 11 | at | Cincinnati | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Seton Hall | 12 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| South Florida | 17 | at | UCF | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Wagner |
| at | Rutgers |
| Postponed | | Recap | PPD to 4/22, rain |
| 4/1/2008 |
| Western Michigan |
| at | Notre Dame |
| Postponed | | Recap | PPD to 5/12, inclement weather |
| Big South Conference |
| 4/1/2008 |
| Elon |
| at | #21 Coastal Carolina |
| Postponed | | Recap | PPD, rain |
| 4/1/2008 |
| College of Charleston |
| at | Charleston Southern |
| Suspended | | Recap | Suspended to 4/16, rain (4-0 CoC, top 7) |
| 4/1/2008 |
| North Carolina-Asheville | 8 | at | Appalachian State | 23 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Radford | 5 | at | Virginia Tech | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Richmond | 5 | at | VMI | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| William and Mary | 9 | at | Liberty | 7 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/1/2008 |
| #9 Long Beach State | 6 | at | Fresno State | 7 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #19 Cal State Fullerton | 8 | at | Loyola Marymount | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Pepperdine | 0 | at | UC Santa Barbara | 14 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| UC Davis | 10 | at | Cal State Sacramento | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| UC Riverside | 5 | at | Southern California | 7 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/1/2008 |
| Towson | 8 | at | #12 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Wake Forest | 1 | at | #30 North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Boston College | 8 | at | Northeastern | 7 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Delaware |
| at | Lafayette |
| Postponed | | Recap | PPD to 4/2, inclement weather (Liberty Bell Classic) |
| 4/1/2008 |
| Georgia State |
| at | Alabama A&M |
| Postponed | | Recap | PPD, impending weather |
| 4/1/2008 |
| Georgia State |
| at | Alabama A&M |
| Postponed | | Recap | PPD, impending weather |
| 4/1/2008 |
| Hofstra | 9 | at | St. Peter's | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Virginia Commonwealth |
| at | Longwood |
| Canceled | | Recap | CCD, rain |
| 4/1/2008 |
| William and Mary | 9 | at | Liberty | 7 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/1/2008 |
| #15 Rice | 7 | at | #13 Texas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #27 Mississippi |
| at | Memphis |
| Postponed | | Recap | PPD, inclement weather |
| 4/1/2008 |
| Alabama-Birmingham | 4 | at | Alabama | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Marshall | 12 | at | Dayton | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| McNeese State | 3 | at | Tulane | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| North Carolina State | 4 | at | East Carolina | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| South Florida | 17 | at | UCF | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Troy | 4 | at | Southern Mississippi | 7 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/1/2008 |
| Chicago State | 1 | at | Illinois-Chicago | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Dallas Baptist | 4 | at | Oklahoma | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Fordham | 5 | at | New York Tech | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Furman |
| at | Presbyterian |
| Postponed | | Recap | PPD to 4/2, inclement weather |
| 4/1/2008 |
| North Carolina Central | 1 | at | Campbell | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| St. Bonaventure |
| at | LeMoyne |
| Postponed | | Recap | PPD, weather and field conditions |
| 4/1/2008 |
| Texas-Pan American | 1 | at | Texas-Arlington | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Texas-Pan American | 1 | at | Texas-Arlington | 11 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/1/2008 |
| Virginia Commonwealth |
| at | Longwood |
| Canceled | | Recap | CCD, rain |
| Horizon League |
| 4/1/2008 |
| Bowling Green State | 13 | at | Youngstown State | 18 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Chicago State | 1 | at | Illinois-Chicago | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Eastern Michigan |
| at | Cleveland State |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Wright State | 12 | at | Xavier | 11 | FINAL | Box Score | Recap | |
| Ivy League |
| 4/1/2008 |
| Army | 19 | at | Columbia | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Princeton | 8 | at | Monmouth | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| St. Joseph's |
| at | Pennsylvania |
| Postponed | | Recap | PPD to 4/2, inclement weather (Liberty Bell Classic) |
| Metro Atlantic Athletic Conference |
| 4/1/2008 |
| Hofstra | 9 | at | St. Peter's | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Niagara | 8 | at | Kent State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Quinnipiac |
| at | Siena |
| Canceled | | Recap | CCD, weather and field conditions |
| 4/1/2008 |
| Seton Hall | 12 | at | Rider | 3 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/1/2008 |
| Bowling Green State | 13 | at | Youngstown State | 18 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Eastern Michigan |
| at | Cleveland State |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Hillsdale | 8 | at | Central Michigan | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Illinois State |
| at | Northern Illinois |
| Postponed | | Recap | PPD to 4/23, cold |
| 4/1/2008 |
| Indiana Tech | 6 | at | Ball State | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Miami, Ohio | 11 | at | Cincinnati | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Niagara | 8 | at | Kent State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Oakland |
| at | Toledo |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Oakland |
| at | Toledo |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Ohio | 4 | at | Duquesne | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Western Michigan |
| at | Notre Dame |
| Postponed | | Recap | PPD to 5/12, inclement weather |
| Mid-Eastern Athletic Conference |
| 4/1/2008 |
| Bethune-Cookman | 4 | at | Stetson | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Florida A&M | 3 | at | Jacksonville | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Georgetown | 12 | at | Coppin State | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Maryland-Eastern Shore | 7 | at | West Virginia | 23 | FINAL | Box Score | Recap | 7 innings |
| 4/1/2008 |
| Maryland-Eastern Shore | 1 | at | West Virginia | 18 | FINAL | Box Score | Recap | 7 innings (400th career win for WV's Greg Van Zant) |
| 4/1/2008 |
| North Carolina A&T | 6 | at | South Carolina-Upstate | 16 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/1/2008 |
| #8 Wichita State | 7 | at | Kansas | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #22 Nebraska |
| at | Creighton |
| Postponed | | Recap | PPD to 4/23, cold |
| 4/1/2008 |
| Arkansas | 7 | at | Missouri State | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/1/2008 |
| Brescia | 1 | at | Evansville | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Illinois | 5 | vs | Southern Illinois | 2 | FINAL | Box Score | Recap | Marion, IL |
| 4/1/2008 |
| Illinois State |
| at | Northern Illinois |
| Postponed | | Recap | PPD to 4/23, cold |
| 4/1/2008 |
| Indiana State |
| at | St. Louis |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Quincy | 4 | at | Bradley | 7 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/1/2008 |
| San Diego State | 2 | at | #28 UCLA | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #29 Baylor | 2 | at | Texas Christian | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Doane | 11 | at | Air Force | 1 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/1/2008 |
| Nevada-Las Vegas | 1 | at | Nevada | 23 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/1/2008 |
| Princeton | 8 | at | Monmouth | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Quinnipiac |
| at | Siena |
| Canceled | | Recap | CCD, weather and field conditions |
| 4/1/2008 |
| Rhode Island |
| at | Central Connecticut State |
| Postponed | | Recap | PPD, field conditions |
| 4/1/2008 |
| Wagner |
| at | Rutgers |
| Postponed | | Recap | PPD to 4/22, rain |
| Ohio Valley Conference |
| 4/1/2008 |
| Southeast Missouri State | 12 | at | #6 Vanderbilt | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Austin Peay State | 4 | at | Mississippi State | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Monmouth (IL) | 3 | at | Eastern Illinois | 4 | FINAL | Box Score | Recap | makeup of 3/18 game |
| 4/1/2008 |
| Samford | 10 | at | Mercer | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Tennessee | 7 | at | Tennessee Tech | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Tennessee-Martin | 9 | at | Arkansas State | 8 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/1/2008 |
| Wofford | 3 | at | #1 Arizona State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #20 California | 1 | at | San Francisco | 5 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| San Diego State | 2 | at | #28 UCLA | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Hawaii | 5 | at | Stanford | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Portland | 6 | at | Washington | 17 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| UC Riverside | 5 | at | Southern California | 7 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/1/2008 |
| Army | 19 | at | Columbia | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Delaware |
| at | Lafayette |
| Postponed | | Recap | PPD to 4/2, inclement weather (Liberty Bell Classic) |
| 4/1/2008 |
| Holy Cross | 9 | at | Massachusetts | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Lehigh | 17 | at | Temple | 15 | FINAL | Box Score | Recap | Liberty Bell Classic |
| 4/1/2008 |
| Navy | 6 | at | Maryland | 13 | FINAL | Box Score | Recap | 400th career win for UM's Terry Rupp |
| Southeastern Conference |
| 4/1/2008 |
| #25 Florida | 2 | vs | #3 Florida State | 10 | FINAL | Box Score | Recap | Jacksonville, FL |
| 4/1/2008 |
| Southeast Missouri State | 12 | at | #6 Vanderbilt | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #7 South Carolina | 7 | at | The Citadel | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #17 Clemson | 3 | at | Georgia | 11 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #27 Mississippi |
| at | Memphis |
| Postponed | | Recap | PPD, inclement weather |
| 4/1/2008 |
| Alabama-Birmingham | 4 | at | Alabama | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Arkansas | 7 | at | Missouri State | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/1/2008 |
| Auburn | 3 | at | South Alabama | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Austin Peay State | 4 | at | Mississippi State | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Louisiana State | 8 | at | Southern | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Tennessee | 7 | at | Tennessee Tech | 9 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/1/2008 |
| Wofford | 3 | at | #1 Arizona State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| North Carolina-Greensboro | 1 | at | #4 North Carolina | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #7 South Carolina | 7 | at | The Citadel | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Elon |
| at | #21 Coastal Carolina |
| Postponed | | Recap | PPD, rain |
| 4/1/2008 |
| College of Charleston |
| at | Charleston Southern |
| Suspended | | Recap | Suspended to 4/16, rain (4-0 CoC, top 7) |
| 4/1/2008 |
| Furman |
| at | Presbyterian |
| Postponed | | Recap | PPD to 4/2, inclement weather |
| 4/1/2008 |
| Georgia Southern | 3 | at | North Florida | 1 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| North Carolina-Asheville | 8 | at | Appalachian State | 23 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Western Carolina | 13 | at | Gardner-Webb | 6 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/1/2008 |
| Stephen F. Austin | 1 | at | #16 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Central Arkansas | 0 | at | Kansas State | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Lamar | 2 | at | Louisiana-Lafayette | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| McNeese State | 3 | at | Tulane | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Nicholls State | 1 | at | New Orleans | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/1/2008 |
| Northwestern State |
| at | Centenary |
| Postponed | | Recap | PPD to 4/9, field conditions |
| 4/1/2008 |
| Southeastern Louisiana | 8 | at | Jackson State | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Texas A&M-Corpus Christi | 1 | at | Texas Tech | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Texas-Pan American | 1 | at | Texas-Arlington | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Texas-Pan American | 1 | at | Texas-Arlington | 11 | FINAL | Box Score | Recap | 8 innings, run rule |
| Southwestern Athletic Conference |
| 4/1/2008 |
| Alabama State | 3 | at | Kennesaw State | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Georgia State |
| at | Alabama A&M |
| Postponed | | Recap | PPD, impending weather |
| 4/1/2008 |
| Georgia State |
| at | Alabama A&M |
| Postponed | | Recap | PPD, impending weather |
| 4/1/2008 |
| Louisiana State | 8 | at | Southern | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Mississippi Valley State | 0 | at | Arkansas-Little Rock | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Rust | 1 | at | Alcorn State | 17 | FINAL | Box Score | | 5 innings, mercy rule |
| 4/1/2008 6:00 PM |
| Rust |
| at | Alcorn State |
|
| | | |
| 4/1/2008 |
| Southeastern Louisiana | 8 | at | Jackson State | 2 | FINAL | Box Score | Recap | |
| Summit League |
| 4/1/2008 |
| Western Illinois | 5 | at | #10 Missouri | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Northwestern State |
| at | Centenary |
| Postponed | | Recap | PPD to 4/9, field conditions |
| 4/1/2008 |
| Oakland |
| at | Toledo |
| Canceled | | Recap | CCD, field conditions |
| 4/1/2008 |
| Oakland |
| at | Toledo |
| Canceled | | Recap | CCD, field conditions |
| Sun Belt Conference |
| 4/1/2008 |
| Florida Atlantic | 7 | at | #2 Miami, Florida | 16 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Auburn | 3 | at | South Alabama | 4 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Florida Gulf Coast | 13 | at | Florida International | 6 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Lamar | 2 | at | Louisiana-Lafayette | 3 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Louisville | 5 | at | Western Kentucky | 10 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Middle Tennessee State | 6 | at | Lipscomb | 13 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Mississippi Valley State | 0 | at | Arkansas-Little Rock | 9 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Nicholls State | 1 | at | New Orleans | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/1/2008 |
| Tennessee-Martin | 9 | at | Arkansas State | 8 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| Troy | 4 | at | Southern Mississippi | 7 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/1/2008 |
| #19 Cal State Fullerton | 8 | at | Loyola Marymount | 2 | FINAL | Box Score | Recap | |
| 4/1/2008 |
| #20 California | 1 | at | San Francisco | 5 | FINAL |