| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/5/2008 | * | #1 Arizona State | 2 | at | Stanford | 12 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #17 Clemson | 5 | at | #2 Miami, Florida | 15 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #12 Virginia |
| at | #3 Florida State |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | #24 Georgia Tech |
| at | #4 North Carolina |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | #19 Cal State Fullerton | 2 | at | #5 UC Irvine | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/5/2008 | * | #6 Vanderbilt | 6 | at | #27 Mississippi | 7 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #6 Vanderbilt | 0 | at | #27 Mississippi | 8 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #7 South Carolina | 0 | at | Georgia | 1 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #7 South Carolina | 3 | at | Georgia | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Missouri State | 8 | at | #8 Wichita State | 19 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/5/2008 | * | #9 Long Beach State | 4 | at | UC Riverside | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #23 Oklahoma State | 6 | at | #10 Missouri | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #11 Arizona | 5 | at | Washington | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #13 Texas | 3 | at | Oklahoma | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Mississippi State | 6 | at | #14 Kentucky | 5 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Mississippi State | 4 | at | #14 Kentucky | 13 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #15 Rice | 3 | at | Memphis | 0 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #15 Rice | 7 | at | Memphis | 1 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Kansas State | 8 | at | #16 Texas A&M | 13 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Gonzaga | 4 | at | #18 San Diego | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #26 Oregon State | 3 | at | #20 California | 9 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Winthrop |
| at | #21 Coastal Carolina |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | Texas Tech | 2 | at | #22 Nebraska | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #25 Florida | 4 | at | Tennessee | 5 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #25 Florida |
| at | Tennessee |
| Suspended | | Recap | Suspended to 4/6, rain (10-5 UT, bottom 6) |
| 4/5/2008 | * | Southern California | 7 | at | #28 UCLA | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Kansas | 6 | at | #29 Baylor | 12 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #30 North Carolina-Wilmington | 4 | at | Northeastern | 6 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #30 North Carolina-Wilmington | 11 | at | Northeastern | 1 | FINAL | Box Score | Recap | 7 innings |
| America East Conference |
| 4/5/2008 | * | Binghamton | 9 | at | Stony Brook | 11 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Binghamton | 4 | at | Stony Brook | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Hartford | 11 | at | Albany | 10 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Hartford | 12 | at | Albany | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Vermont | 17 | at | Maryland-Baltimore County | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Vermont | 4 | at | Maryland-Baltimore County | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 |
| New Jersey Tech | 3 | at | Maine | 15 | FINAL | Box Score | Recap | Bangor, ME |
| Atlantic 10 Conference |
| 4/5/2008 | * | Dayton | 5 | at | St. Bonaventure | 9 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Dayton | 2 | at | St. Bonaventure | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Duquesne | 5 | at | Rhode Island | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Duquesne | 4 | at | Rhode Island | 1 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Fordham | 9 | at | St. Joseph's | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Fordham | 4 | at | St. Joseph's | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | LaSalle | 1 | at | St. Louis | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Massachusetts | 6 | at | George Washington | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | North Carolina-Charlotte | 2 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | North Carolina-Charlotte | 9 | at | Temple | 5 | FINAL | Box Score | Recap | moved from 4/6, impending weather |
| 4/5/2008 | * | Richmond | 3 | at | Xavier | 14 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Richmond | 5 | at | Xavier | 14 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/5/2008 | * | #17 Clemson | 5 | at | #2 Miami, Florida | 15 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #12 Virginia |
| at | #3 Florida State |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | #24 Georgia Tech |
| at | #4 North Carolina |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | Duke | 2 | at | Boston College | 3 | FINAL | Box Score | Recap | makeup of 4/4 game (Brockton, MA) |
| 4/5/2008 | * | Duke | 0 | at | Boston College | 6 | FINAL | Box Score | Recap | Brockton, MA |
| 4/5/2008 | * | Maryland | 13 | at | Virginia Tech | 8 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Wake Forest |
| at | North Carolina State |
| Postponed | | Recap | PPD to 4/6, rain |
| Atlantic Sun Conference |
| 4/5/2008 | * | Belmont | 12 | at | Florida Gulf Coast | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Campbell | 10 | at | North Florida | 4 | FINAL | Box Score | Recap | 5 innings, inclement weather |
| 4/5/2008 | * | Campbell |
| at | North Florida |
| Postponed | | Recap | PPD to 4/7, inclement weather |
| 4/5/2008 | * | East Tennessee State | 6 | at | Kennesaw State | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | East Tennessee State | 5 | at | Kennesaw State | 6 | FINAL | Box Score | Recap | 11 innings |
| 4/5/2008 | * | Lipscomb | 6 | at | Stetson | 12 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Mercer |
| at | Jacksonville |
| Suspended | | Recap | Suspended to 4/6, rain (15-15, bottom 8) |
| 4/5/2008 | * | Mercer |
| at | Jacksonville |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | South Carolina-Upstate |
| at | Gardner-Webb |
| Postponed | | Recap | PPD to 4/6, rain and field conditions |
| 4/5/2008 | * | South Carolina-Upstate |
| at | Gardner-Webb |
| Postponed | | Recap | PPD to 4/6, rain and field conditions |
| Big 10 Conference |
| 4/5/2008 | * | Illinois | 8 | at | Indiana | 7 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Michigan | 1 | at | Penn State | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Michigan | 6 | at | Penn State | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Michigan State | 6 | at | Northwestern | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Michigan State | 2 | at | Northwestern | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Minnesota | 6 | at | Ohio State | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Minnesota | 1 | at | Ohio State | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Purdue | 6 | at | Iowa | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Purdue | 4 | at | Iowa | 3 | FINAL | Box Score | Recap | 7 innings |
| Big 12 Conference |
| 4/5/2008 | * | #23 Oklahoma State | 6 | at | #10 Missouri | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #13 Texas | 3 | at | Oklahoma | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Kansas State | 8 | at | #16 Texas A&M | 13 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Texas Tech | 2 | at | #22 Nebraska | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Kansas | 6 | at | #29 Baylor | 12 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/5/2008 | * | Cincinnati | 5 | at | Connecticut | 3 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Cincinnati | 4 | at | Connecticut | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Georgetown | 3 | at | Villanova | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Pittsburgh | 0 | at | Seton Hall | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Rutgers | 2 | at | Notre Dame | 11 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | South Florida | 8 | at | West Virginia | 10 | FINAL | Box Score | Recap | Resumption of 4/4 game |
| 4/5/2008 | * | South Florida | 14 | at | West Virginia | 15 | FINAL | Box Score | Recap | 10 innings |
| 4/5/2008 | * | St. John's | 6 | at | Louisville | 3 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/5/2008 | * | Winthrop |
| at | #21 Coastal Carolina |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | High Point | 2 | at | Charleston Southern | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | High Point | 5 | at | Charleston Southern | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Liberty | 14 | at | North Carolina-Asheville | 13 | FINAL | Box Score | Recap | 10 innings |
| 4/5/2008 | * | Radford |
| at | VMI |
| Suspended | | Recap | Suspended to 4/6 (1-1, top 10) |
| Big West Conference |
| 4/5/2008 | * | #19 Cal State Fullerton | 2 | at | #5 UC Irvine | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/5/2008 | * | #9 Long Beach State | 4 | at | UC Riverside | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Cal Poly | 2 | at | Cal State Northridge | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/5/2008 | * | UC Santa Barbara | 3 | at | Pacific | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| UC Davis | 4 | at | Washington State | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| UC Davis | 5 | at | Washington State | 7 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/5/2008 | * | #30 North Carolina-Wilmington | 4 | at | Northeastern | 6 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #30 North Carolina-Wilmington | 11 | at | Northeastern | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | George Mason | 1 | at | Towson | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Hofstra | 10 | at | Delaware | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Hofstra | 6 | at | Delaware | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Virginia Commonwealth |
| at | Old Dominion |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | William and Mary |
| at | Georgia State |
| Postponed | | Recap | PPD to 4/6, rain (makeup of 4/4 game) |
| 4/5/2008 | * | William and Mary |
| at | Georgia State |
| Canceled | | Recap | CCD, rain |
| 4/5/2008 |
| Longwood | 3 | at | James Madison | 15 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Longwood | 4 | at | James Madison | 3 | FINAL | Box Score | Recap | 7 innings |
| Conference USA |
| 4/5/2008 | * | #15 Rice | 3 | at | Memphis | 0 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #15 Rice | 7 | at | Memphis | 1 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | East Carolina | 5 | at | Southern Mississippi | 6 | FINAL | Box Score | Recap | 13 innings (makeup of 4/4 game) |
| 4/5/2008 | * | East Carolina | 4 | at | Southern Mississippi | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Marshall | 7 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | UCF | 1 | at | Houston | 10 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Presbyterian | 7 | at | Alabama-Birmingham | 2 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 |
| Presbyterian |
| at | Alabama-Birmingham |
| Postponed | | Recap | PPD to 4/6, field conditions |
| Division I Independents |
| 4/5/2008 |
| Chicago State | 3 | at | Southern | 8 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Florida A&M |
| at | Savannah State |
| Canceled | | Recap | CCD, inclement weather |
| 4/5/2008 |
| Hawaii-Hilo | 4 | at | Hawaii Pacific | 2 | FINAL | Box Score | Recap | 10 innings |
| 4/5/2008 |
| Hawaii-Hilo | 8 | at | Hawaii Pacific | 9 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 |
| LeMoyne | 5 | at | Niagara | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| LeMoyne | 2 | at | Niagara | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 |
| Longwood | 3 | at | James Madison | 15 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Longwood | 4 | at | James Madison | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 |
| New Jersey Tech | 3 | at | Maine | 15 | FINAL | Box Score | Recap | Bangor, ME |
| 4/5/2008 |
| New Orleans | 11 | at | Texas-Pan American | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| North Carolina Central |
| at | Chowan |
| Postponed | | | PPD to 4/26 |
| 4/5/2008 |
| North Carolina Central |
| at | Chowan |
| Postponed | | | PPD to 4/26 |
| 4/5/2008 |
| Northern Colorado | 3 | at | Dallas Baptist | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Northern Colorado | 10 | at | Dallas Baptist | 15 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Presbyterian | 7 | at | Alabama-Birmingham | 2 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 |
| Presbyterian |
| at | Alabama-Birmingham |
| Postponed | | Recap | PPD to 4/6, field conditions |
| 4/5/2008 |
| Utah | 17 | at | Utah Valley State | 16 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/5/2008 | * | Butler | 6 | at | Illinois-Chicago | 11 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Butler | 6 | at | Illinois-Chicago | 7 | FINAL | Box Score | Recap | 13 innings |
| 4/5/2008 | * | Valparaiso | 0 | at | Youngstown State | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Valparaiso | 1 | at | Youngstown State | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Wright State | 5 | at | Cleveland State | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Wright State | 5 | at | Cleveland State | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Wisconsin-Milwaukee | 4 | at | Southern Illinois | 5 | FINAL | Box Score | Recap | |
| Ivy League |
| 4/5/2008 | * | Columbia |
| at | Harvard |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | Columbia |
| at | Harvard |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | Cornell | 4 | at | Brown | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Cornell | 7 | at | Brown | 11 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Princeton | 2 | at | Yale | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Princeton | 8 | at | Yale | 5 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/5/2008 | * | Fairfield | 11 | at | St. Peter's | 10 | FINAL | Box Score | Recap | 11 innings |
| 4/5/2008 | * | Marist | 5 | at | Iona | 1 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Rider | 7 | at | Canisius | 6 | FINAL | Box Score | Recap | 11 innings |
| 4/5/2008 | * | Rider | 3 | at | Canisius | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Siena |
| at | Manhattan |
| Postponed | | Recap | PPD to 4/7, inclement weather |
| 4/5/2008 |
| LeMoyne | 5 | at | Niagara | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| LeMoyne | 2 | at | Niagara | 3 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 4/5/2008 | * | Buffalo | 1 | at | Ball State | 3 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Buffalo | 1 | at | Ball State | 16 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Central Michigan | 3 | at | Bowling Green State | 10 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Central Michigan | 6 | at | Bowling Green State | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Eastern Michigan | 2 | at | Akron | 6 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Eastern Michigan | 5 | at | Akron | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Kent State | 2 | at | Northern Illinois | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Ohio | 4 | at | Toledo | 9 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Ohio | 18 | at | Toledo | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Western Michigan | 4 | at | Miami, Ohio | 5 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/5/2008 | * | Coppin State | 2 | at | Delaware State | 12 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/5/2008 | * | Coppin State | 1 | at | Delaware State | 13 | FINAL | Box Score | Recap | 5 innings, run rule |
| 4/5/2008 | * | Maryland-Eastern Shore |
| at | Norfolk State |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | Maryland-Eastern Shore |
| at | Norfolk State |
| Postponed | | Recap | PPD to 4/6, inclement weather |
| 4/5/2008 | * | North Carolina A&T | 6 | at | Bethune-Cookman | 18 | FINAL | Box Score | | 7 innings |
| 4/5/2008 | * | North Carolina A&T | 7 | at | Bethune-Cookman | 10 | FINAL | Box Score | | 7 innings |
| 4/5/2008 |
| Florida A&M |
| at | Savannah State |
| Canceled | | Recap | CCD, inclement weather |
| Missouri Valley Conference |
| 4/5/2008 | * | Missouri State | 8 | at | #8 Wichita State | 19 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/5/2008 | * | Creighton | 12 | at | Bradley | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Illinois State | 11 | at | Evansville | 1 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Illinois State | 7 | at | Evansville | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Northern Iowa | 12 | at | Indiana State | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Wisconsin-Milwaukee | 4 | at | Southern Illinois | 5 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/5/2008 | * | Air Force | 3 | at | Texas Christian | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Brigham Young | 21 | at | Nevada-Las Vegas | 12 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | New Mexico | 5 | at | San Diego State | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| Utah | 17 | at | Utah Valley State | 16 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/5/2008 | * | Long Island | 5 | at | Wagner | 16 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Long Island | 0 | at | Wagner | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Monmouth | 12 | at | Sacred Heart | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Monmouth | 12 | at | Sacred Heart | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Mount St. Mary's | 7 | at | Fairleigh Dickinson | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Mount St. Mary's |
| at | Fairleigh Dickinson |
| Suspended | | Recap | Suspended to 4/6, darkness (0-0, top 11) |
| 4/5/2008 | * | Quinnipiac | 2 | at | Central Connecticut State | 3 | FINAL | Box Score | Recap | 11 innings |
| 4/5/2008 | * | Quinnipiac | 2 | at | Central Connecticut State | 5 | FINAL | Box Score | Recap | 7 innings |
| Ohio Valley Conference |
| 4/5/2008 | * | Morehead State | 4 | at | Austin Peay State | 26 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Morehead State | 3 | at | Austin Peay State | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Murray State | 5 | at | Southeast Missouri State | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Murray State | 2 | at | Southeast Missouri State | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Samford | 6 | at | Jacksonville State | 7 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Samford | 4 | at | Jacksonville State | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Tennessee Tech | 1 | at | Eastern Kentucky | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Tennessee Tech |
| at | Eastern Kentucky |
| Postponed | | | PPD to 4/6 |
| 4/5/2008 | * | Tennessee-Martin | 4 | at | Eastern Illinois | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Tennessee-Martin | 6 | at | Eastern Illinois | 8 | FINAL | Box Score | Recap | 7 innings |
| Pac 10 Conference |
| 4/5/2008 | * | #1 Arizona State | 2 | at | Stanford | 12 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #11 Arizona | 5 | at | Washington | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #26 Oregon State | 3 | at | #20 California | 9 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Southern California | 7 | at | #28 UCLA | 4 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| UC Davis | 4 | at | Washington State | 6 | FINAL | Box Score | Recap | |
| 4/5/2008 |
| UC Davis | 5 | at | Washington State | 7 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/5/2008 | * | Army | 0 | at | Holy Cross | 9 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Army | 16 | at | Holy Cross | 0 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Bucknell | 0 | at | Lafayette | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Bucknell | 10 | at | Lafayette | 2 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Lehigh | 2 | at | Navy | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/5/2008 | * | Lehigh | 1 | at | Navy | 4 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/5/2008 | * | #6 Vanderbilt | 6 | at | #27 Mississippi | 7 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #6 Vanderbilt | 0 | at | #27 Mississippi | 8 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #7 South Carolina | 0 | at | Georgia | 1 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #7 South Carolina | 3 | at | Georgia | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Mississippi State | 6 | at | #14 Kentucky | 5 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Mississippi State | 4 | at | #14 Kentucky | 13 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | #25 Florida | 4 | at | Tennessee | 5 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | #25 Florida |
| at | Tennessee |
| Suspended | | Recap | Suspended to 4/6, rain (10-5 UT, bottom 6) |
| 4/5/2008 | * | Alabama | 0 | at | Louisiana State | 3 | FINAL | Box Score | Recap | Resumption of 4/4 game |
| 4/5/2008 | * | Alabama | 6 | at | Louisiana State | 5 | FINAL | Box Score | Recap | 11 innings |
| 4/5/2008 | * | Auburn | 4 | at | Arkansas | 5 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/5/2008 | * | College of Charleston |
| at | Appalachian State |
| Suspended | | Recap | Suspended to 4/6, fog (8-2 CoC, bottom 8) |
| 4/5/2008 | * | Davidson | 7 | at | Western Carolina | 22 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/5/2008 | * | Davidson | 8 | at | Western Carolina | 10 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Furman | 5 | at | North Carolina-Greensboro | 2 | FINAL | Box Score | Recap | Resumption of 4/4 game |
| 4/5/2008 | * | Furman |
| at | North Carolina-Greensboro |
| Postponed | | Recap | PPD to 4/6 |
| 4/5/2008 | * | Georgia Southern |
| at | Elon |
| Postponed | | Recap | PPD to 4/6, rain |
| 4/5/2008 | * | The Citadel | 6 | at | Wofford | 2 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/5/2008 | * | Lamar | 5 | at | Nicholls State | 8 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | McNeese State | 5 | at | Northwestern State | 3 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | McNeese State |
| at | Northwestern State |
| Postponed | | Recap | PPD to 4/6, field conditions (makeup of 4/4 game) |
| 4/5/2008 | * | Sam Houston State | 6 | at | Texas-Arlington | 5 | FINAL | Box Score | Recap | |
| 4/5/2008 | * | Stephen F. Austin | 10 | at | Central Arkansas | |