| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/6/2008 | * | #1 Arizona State | 2 | at | Stanford | 10 | FINAL | Box Score | Recap | 1,300th career victory for Mark Marquess (Stan) |
| 4/6/2008 | * | #17 Clemson | 6 | at | #2 Miami, Florida | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #12 Virginia | 2 | at | #3 Florida State | 3 | FINAL | Box Score | Recap | 10 innings (makeup of 4/5 game) |
| 4/6/2008 | * | #12 Virginia | 2 | at | #3 Florida State | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/6/2008 | * | #24 Georgia Tech | 4 | at | #4 North Carolina | 10 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | #24 Georgia Tech | 4 | at | #4 North Carolina | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #19 Cal State Fullerton | 6 | at | #5 UC Irvine | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #6 Vanderbilt | 6 | at | #27 Mississippi | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #7 South Carolina | 2 | at | Georgia | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Missouri State | 5 | at | #8 Wichita State | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #9 Long Beach State | 1 | at | UC Riverside | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #23 Oklahoma State | 8 | at | #10 Missouri | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #11 Arizona | 1 | at | Washington | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #13 Texas | 13 | at | Oklahoma | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Mississippi State | 8 | at | #14 Kentucky | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #15 Rice | 7 | at | Memphis | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Kansas State | 4 | at | #16 Texas A&M | 14 | FINAL | Box Score | Recap | 8 innings |
| 4/6/2008 | * | Gonzaga | 3 | at | #18 San Diego | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #26 Oregon State | 9 | at | #20 California | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Winthrop | 1 | at | #21 Coastal Carolina | 5 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Winthrop | 8 | at | #21 Coastal Carolina | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Texas Tech | 3 | at | #22 Nebraska | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #25 Florida | 6 | at | Tennessee | 12 | FINAL | Box Score | Recap | Resumption of 4/5 game |
| 4/6/2008 | * | #25 Florida | 7 | at | Tennessee | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Southern California | 2 | at | #28 UCLA | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Kansas | 7 | at | #29 Baylor | 17 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/6/2008 | * | #30 North Carolina-Wilmington | 3 | at | Northeastern | 3 | FINAL | Box Score | Recap | 12 innings, travel curfew |
| America East Conference |
| 4/6/2008 | * | Binghamton | 6 | at | Stony Brook | 7 | FINAL | Box Score | Recap | 7 innings (makeup of 4/4 game) |
| 4/6/2008 | * | Binghamton | 2 | at | Stony Brook | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Hartford | 2 | at | Albany | 6 | FINAL | Box Score | Recap | 7 innings (makeup of 4/4 game) |
| 4/6/2008 | * | Hartford | 3 | at | Albany | 1 | FINAL | Box Score | Recap | 11 innings |
| 4/6/2008 | * | Vermont | 13 | at | Maryland-Baltimore County | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| New Jersey Tech | 0 | at | Maine | 19 | FINAL | Box Score | Recap | Bangor, ME |
| Atlantic 10 Conference |
| 4/6/2008 | * | Dayton | 6 | at | St. Bonaventure | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Duquesne | 7 | at | Rhode Island | 6 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 | * | Fordham | 3 | at | St. Joseph's | 6 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 | * | LaSalle | 8 | at | St. Louis | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Massachusetts | 4 | at | George Washington | 0 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Richmond | 9 | at | Xavier | 2 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/6/2008 | * | #17 Clemson | 6 | at | #2 Miami, Florida | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #12 Virginia | 2 | at | #3 Florida State | 3 | FINAL | Box Score | Recap | 10 innings (makeup of 4/5 game) |
| 4/6/2008 | * | #12 Virginia | 2 | at | #3 Florida State | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/6/2008 | * | #24 Georgia Tech | 4 | at | #4 North Carolina | 10 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | #24 Georgia Tech | 4 | at | #4 North Carolina | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Duke | 6 | at | Boston College | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Maryland | 5 | at | Virginia Tech | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Wake Forest | 4 | at | North Carolina State | 14 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Wake Forest | 6 | at | North Carolina State | 18 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/6/2008 | * | East Tennessee State | 2 | at | Kennesaw State | 8 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 | * | Lipscomb | 11 | at | Stetson | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Mercer | 20 | at | Jacksonville | 15 | FINAL | Box Score | Recap | Resumption of 4/5 game |
| 4/6/2008 | * | Mercer | 10 | at | Jacksonville | 11 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | South Carolina-Upstate | 2 | at | Gardner-Webb | 1 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | South Carolina-Upstate | 4 | at | Gardner-Webb | 9 | FINAL | Box Score | Recap | makeup of 4/5 game |
| Big 10 Conference |
| 4/6/2008 | * | Illinois | 1 | at | Indiana | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Illinois | 7 | at | Indiana | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Michigan | 1 | at | Penn State | 10 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Michigan State | 4 | at | Northwestern | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Minnesota | 7 | at | Ohio State | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Purdue | 16 | at | Iowa | 3 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/6/2008 | * | #23 Oklahoma State | 8 | at | #10 Missouri | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #13 Texas | 13 | at | Oklahoma | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Kansas State | 4 | at | #16 Texas A&M | 14 | FINAL | Box Score | Recap | 8 innings |
| 4/6/2008 | * | Texas Tech | 3 | at | #22 Nebraska | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Kansas | 7 | at | #29 Baylor | 17 | FINAL | Box Score | Recap | 7 innings, run rule |
| Big East Conference |
| 4/6/2008 | * | Cincinnati | 6 | at | Connecticut | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Georgetown | 1 | at | Villanova | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Pittsburgh | 5 | at | Seton Hall | 15 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Rutgers | 2 | at | Notre Dame | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | South Florida | 5 | at | West Virginia | 2 | FINAL | Box Score | Recap | 11 innings |
| 4/6/2008 | * | St. John's | 3 | at | Louisville | 10 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/6/2008 | * | Winthrop | 1 | at | #21 Coastal Carolina | 5 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Winthrop | 8 | at | #21 Coastal Carolina | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | High Point | 8 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 | * | Liberty | 11 | at | North Carolina-Asheville | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Radford | 3 | at | VMI | 4 | FINAL | Box Score | Recap | 11 innings (Resumption of 4/5 game) |
| 4/6/2008 | * | Radford | 5 | at | VMI | 9 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/6/2008 | * | #19 Cal State Fullerton | 6 | at | #5 UC Irvine | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #9 Long Beach State | 1 | at | UC Riverside | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Cal Poly | 3 | at | Cal State Northridge | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | UC Santa Barbara | 12 | at | Pacific | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| UC Davis | 13 | at | Washington State | 11 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/6/2008 | * | #30 North Carolina-Wilmington | 3 | at | Northeastern | 3 | FINAL | Box Score | Recap | 12 innings, travel curfew |
| 4/6/2008 | * | George Mason | 5 | at | Towson | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Virginia Commonwealth |
| at | Old Dominion |
| Canceled | | Recap | CCD, rain (makeup of 4/5 game) |
| 4/6/2008 | * | Virginia Commonwealth |
| at | Old Dominion |
| Canceled | | Recap | CCD, rain |
| 4/6/2008 | * | William and Mary | 3 | at | Georgia State | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | William and Mary | 3 | at | Georgia State | 6 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 |
| James Madison |
| at | Longwood |
| Postponed | | Recap | PPD to 4/7, rain |
| 4/6/2008 |
| James Madison |
| at | Longwood |
| Postponed | | Recap | PPD to 4/7, rain |
| Conference USA |
| 4/6/2008 | * | #15 Rice | 7 | at | Memphis | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | East Carolina | 11 | at | Southern Mississippi | 3 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Marshall | 5 | at | Tulane | 5 | FINAL | Box Score | Recap | 10 innings, travel curfew |
| 4/6/2008 | * | UCF | 7 | at | Houston | 14 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Presbyterian | 2 | at | Alabama-Birmingham | 3 | FINAL | Box Score | Recap | 7 innings (makeup of 4/5 game) |
| 4/6/2008 |
| Presbyterian | 1 | at | Alabama-Birmingham | 3 | FINAL | Box Score | Recap | 7 innings |
| Division I Independents |
| 4/6/2008 |
| Chicago State | 9 | at | Jackson State | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Florida A&M |
| at | Savannah State |
| Canceled | | Recap | CCD, inclement weather |
| 4/6/2008 |
| Hawaii-Hilo | 6 | at | Hawaii Pacific | 4 | FINAL | Box Score | Recap | 8 innings |
| 4/6/2008 |
| Hawaii-Hilo | 2 | at | Hawaii Pacific | 14 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 |
| James Madison |
| at | Longwood |
| Postponed | | Recap | PPD to 4/7, rain |
| 4/6/2008 |
| James Madison |
| at | Longwood |
| Postponed | | Recap | PPD to 4/7, rain |
| 4/6/2008 |
| LeMoyne | 6 | at | Niagara | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| New Jersey Tech | 0 | at | Maine | 19 | FINAL | Box Score | Recap | Bangor, ME |
| 4/6/2008 |
| New Jersey Tech | 2 | vs | New York Tech | 11 | FINAL | Box Score | Recap | Bangor, ME |
| 4/6/2008 |
| New Orleans | 5 | at | Texas-Pan American | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Presbyterian | 2 | at | Alabama-Birmingham | 3 | FINAL | Box Score | Recap | 7 innings (makeup of 4/5 game) |
| 4/6/2008 |
| Presbyterian | 1 | at | Alabama-Birmingham | 3 | FINAL | Box Score | Recap | 7 innings |
| Horizon League |
| 4/6/2008 | * | Wright State | 3 | at | Cleveland State | 2 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 |
| Wisconsin-Milwaukee | 2 | at | Southern Illinois | 5 | FINAL | Box Score | Recap | |
| Ivy League |
| 4/6/2008 | * | Columbia | 2 | at | Harvard | 0 | FINAL | Box Score | Recap | 7 innings (makeup of 4/5 game) |
| 4/6/2008 | * | Columbia | 10 | at | Harvard | 2 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Cornell | 1 | at | Yale | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Cornell | 5 | at | Yale | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Pennsylvania | 1 | at | Dartmouth | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Pennsylvania | 3 | at | Dartmouth | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Princeton | 1 | at | Brown | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Princeton | 14 | at | Brown | 11 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/6/2008 | * | Fairfield | 10 | at | St. Peter's | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Fairfield | 2 | at | St. Peter's | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Marist | 2 | at | Iona | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Marist | 6 | at | Iona | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Rider | 7 | at | Canisius | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Siena | 16 | at | Manhattan | 10 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Siena | 3 | at | Manhattan | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 |
| LeMoyne | 6 | at | Niagara | 8 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/6/2008 | * | Buffalo | 3 | at | Ball State | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Central Michigan | 10 | at | Bowling Green State | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Eastern Michigan | 12 | at | Akron | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Kent State | 9 | at | Northern Illinois | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Ohio | 17 | at | Toledo | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Western Michigan | 13 | at | Miami, Ohio | 7 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/6/2008 | * | Coppin State | 3 | at | Delaware State | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Maryland-Eastern Shore |
| at | Norfolk State |
| Postponed | | Recap | PPD to 4/7, field conditions (makeup of 4/5 game) |
| 4/6/2008 | * | Maryland-Eastern Shore |
| at | Norfolk State |
| Postponed | | Recap | PPD to 4/7, field conditions (makeup of 4/5 game) |
| 4/6/2008 | * | North Carolina A&T | 1 | at | Bethune-Cookman | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Florida A&M |
| at | Savannah State |
| Canceled | | Recap | CCD, inclement weather |
| Missouri Valley Conference |
| 4/6/2008 | * | Missouri State | 5 | at | #8 Wichita State | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Creighton | 3 | at | Bradley | 4 | FINAL | Box Score | Recap | 12 innings |
| 4/6/2008 | * | Illinois State | 6 | at | Evansville | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Northern Iowa | 6 | at | Indiana State | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Wisconsin-Milwaukee | 2 | at | Southern Illinois | 5 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/6/2008 | * | Air Force | 2 | at | Texas Christian | 3 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | New Mexico | 2 | at | San Diego State | 3 | FINAL | Box Score | Recap | 11 innings |
| Northeast Conference |
| 4/6/2008 | * | Long Island | 0 | at | Wagner | 2 | FINAL | Box Score | Recap | 7 innings (makeup of 4/4 game) |
| 4/6/2008 | * | Long Island | 2 | at | Wagner | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Monmouth | 17 | at | Sacred Heart | 0 | FINAL | Box Score | Recap | 7 innings (makeup of 4/4 game) |
| 4/6/2008 | * | Monmouth | 5 | at | Sacred Heart | 4 | FINAL | Box Score | Recap | 11 innings |
| 4/6/2008 | * | Mount St. Mary's | 1 | at | Fairleigh Dickinson | 0 | FINAL | Box Score | Recap | 11 innings (Resumption of 4/5 game) |
| 4/6/2008 | * | Mount St. Mary's | 1 | at | Fairleigh Dickinson | 4 | FINAL | Box Score | Recap | makeup of 4/4 game |
| 4/6/2008 | * | Quinnipiac | 3 | at | Central Connecticut State | 5 | FINAL | Box Score | Recap | 7 innings (makeup of 4/4 game) |
| 4/6/2008 | * | Quinnipiac | 1 | at | Central Connecticut State | 6 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 4/6/2008 | * | Morehead State | 2 | at | Austin Peay State | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Murray State | 8 | at | Southeast Missouri State | 9 | FINAL | Box Score | Recap | 400th career win for SEMO's Mark Hogan |
| 4/6/2008 | * | Samford | 9 | at | Jacksonville State | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Tennessee Tech | 7 | at | Eastern Kentucky | 4 | FINAL | Box Score | Recap | 7 innings (makeup of 4/5 game) |
| 4/6/2008 | * | Tennessee Tech | 7 | at | Eastern Kentucky | 6 | FINAL | Box Score | Recap | 8 innings |
| 4/6/2008 | * | Tennessee-Martin | 2 | at | Eastern Illinois | 13 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/6/2008 | * | #1 Arizona State | 2 | at | Stanford | 10 | FINAL | Box Score | Recap | 1,300th career victory for Mark Marquess (Stan) |
| 4/6/2008 | * | #11 Arizona | 1 | at | Washington | 5 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #26 Oregon State | 9 | at | #20 California | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Southern California | 2 | at | #28 UCLA | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| UC Davis | 13 | at | Washington State | 11 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/6/2008 | * | Army | 1 | at | Holy Cross | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Army | 8 | at | Holy Cross | 1 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Bucknell | 5 | at | Lafayette | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Bucknell | 1 | at | Lafayette | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Lehigh | 2 | vs | Navy | 4 | FINAL | Box Score | Recap | 7 innings (Bethlehem, PA) |
| 4/6/2008 | * | Lehigh | 6 | vs | Navy | 5 | FINAL | Box Score | Recap | Bethlehem, PA |
| Southeastern Conference |
| 4/6/2008 | * | #6 Vanderbilt | 6 | at | #27 Mississippi | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #7 South Carolina | 2 | at | Georgia | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Mississippi State | 8 | at | #14 Kentucky | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | #25 Florida | 6 | at | Tennessee | 12 | FINAL | Box Score | Recap | Resumption of 4/5 game |
| 4/6/2008 | * | #25 Florida | 7 | at | Tennessee | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/6/2008 | * | Alabama | 7 | at | Louisiana State | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Auburn | 12 | at | Arkansas | 10 | FINAL | Box Score | Recap | 10 innings |
| Southern Conference |
| 4/6/2008 | * | College of Charleston | 8 | at | Appalachian State | 2 | FINAL | Box Score | Recap | Resumption of 4/5 game |
| 4/6/2008 | * | College of Charleston | 7 | at | Appalachian State | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/6/2008 | * | Davidson | 4 | at | Western Carolina | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Furman | 3 | at | North Carolina-Greensboro | 5 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Furman | 5 | at | North Carolina-Greensboro | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Georgia Southern | 10 | at | Elon | 11 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | Georgia Southern | 8 | at | Elon | 12 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | The Citadel | 18 | at | Wofford | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | The Citadel | 5 | at | Wofford | 6 | FINAL | Box Score | Recap | 10 innings (makeup of 4/4 game) |
| Southland Conference |
| 4/6/2008 | * | Lamar | 7 | at | Nicholls State | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | McNeese State | 4 | at | Northwestern State | 5 | FINAL | Box Score | Recap | makeup of 4/5 game |
| 4/6/2008 | * | McNeese State | 2 | at | Northwestern State | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Sam Houston State | 5 | at | Texas-Arlington | 6 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Stephen F. Austin | 10 | at | Central Arkansas | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Texas A&M-Corpus Christi | 4 | at | Texas State | 13 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Texas-San Antonio | 2 | at | Southeastern Louisiana | 4 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/6/2008 | * | Mississippi Valley State | 4 | at | Alabama State | 1 | FINAL | Box Score | | 7 innings |
| 4/6/2008 | * | Mississippi Valley State | 6 | at | Alabama State | 8 | FINAL | Box Score | | 7 innings |
| 4/6/2008 | * | Prairie View A&M | 18 | at | Arkansas-Pine Bluff | 12 | FINAL | Box Score | | |
| 4/6/2008 | * | Texas Southern | 7 | at | Grambling State | 15 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Chicago State | 9 | at | Jackson State | 11 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| Southern | 20 | at | Jackson State | 5 | FINAL | Box Score | Recap | 8 innings |
| Summit League |
| 4/6/2008 | * | Centenary | 1 | at | South Dakota State | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | North Dakota State | 6 | at | Oral Roberts | 7 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Oakland | 11 | at | Western Illinois | 9 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/6/2008 | * | Arkansas State | 2 | at | Troy | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Arkansas-Little Rock | 8 | at | Louisiana-Monroe | 12 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Florida Atlantic | 9 | at | South Alabama | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Florida International | 9 | at | Western Kentucky | 10 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Louisiana-Lafayette | 8 | at | Middle Tennessee State | 4 | FINAL | Box Score | Recap | |
| 4/6/2008 |
| New Orleans | 5 | at | Texas-Pan American | 2 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/6/2008 | * | Gonzaga | 3 | at | #18 San Diego | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Loyola Marymount | 2 | at | San Francisco | 8 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Pepperdine | 20 | at | St. Mary's | 9 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | Portland | 6 | at | Santa Clara | 2 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/6/2008 | * | Hawaii | 6 | at | San Jose State | 2 | FINAL | Box Score | Recap | |
| 4/6/2008 | * | New Mexico State | 1 | at | Nevada | 11 | FINAL | Box Score | Recap | 7 innings |