| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/11/2008 | * | #1 Miami, Florida |
| at | #25 Georgia Tech |
| Postponed | | Recap | PPD to 4/12 |
| 4/11/2008 | * | #2 Florida State | 8 | at | Boston College | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #2 Florida State | 4 | at | Boston College | 3 | FINAL | Box Score | Recap | moved from 4/12, impending weather |
| 4/11/2008 | * | #3 Arizona State | 15 | at | Washington State | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #4 North Carolina |
| at | #27 Clemson |
| Suspended | | Recap | Suspended to 4/12, inclement weather (5-0 UNC, top 7) |
| 4/11/2008 | * | #5 Wichita State |
| at | Creighton |
| Postponed | | Recap | PPD to 4/13, inclement weather |
| 4/11/2008 | * | #6 UC Irvine | 10 | at | #16 Long Beach State | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Alabama-Birmingham | 11 | at | #7 Rice | 13 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Oklahoma | 7 | at | #8 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #9 Kentucky | 2 | at | #24 Georgia | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #10 South Carolina | 7 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #11 Texas | 12 | at | #12 Missouri | 31 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #13 Vanderbilt | 15 | at | Mississippi State | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #14 Nebraska | 0 | at | #20 Oklahoma State | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Cal State Northridge | 0 | at | #15 Cal State Fullerton | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #17 California | 1 | at | Southern California | 17 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #18 San Diego | 8 | at | Portland | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #19 Virginia | 11 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #21 Coastal Carolina | 14 | at | Charleston Southern | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Indiana State | 2 | at | #22 Arizona | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Louisiana State | 1 | at | #23 Mississippi | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #26 Stanford | 9 | at | Oregon State | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/11/2008 | * | Georgia State | 5 | at | #28 North Carolina-Wilmington | 6 | FINAL | Box Score | Recap | 11 innings |
| 4/11/2008 | * | Arkansas | 2 | at | #29 Florida | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #30 Baylor | 1 | at | Kansas State | 6 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/11/2008 | * | Albany | 11 | at | Maine | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Albany | 0 | at | Maine | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/11/2008 | * | Hartford | 5 | at | Stony Brook | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Maryland-Baltimore County | 8 | at | Binghamton | 9 | FINAL | Box Score | Recap | 10 innings |
| Atlantic 10 Conference |
| 4/11/2008 | * | George Washington | 0 | at | Fordham | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | LaSalle | 9 | at | Duquesne | 18 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Massachusetts | 2 | at | St. Bonaventure | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Richmond | 23 | at | Temple | 0 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | St. Joseph's | 9 | at | Dayton | 4 | FINAL | Box Score | Recap | Xenia, OH (moved from Dayton, field conditions) |
| 4/11/2008 | * | St. Louis | 1 | at | Rhode Island | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | St. Louis | 6 | at | Rhode Island | 7 | FINAL | Box Score | Recap | moved from 4/12, impending weather |
| 4/11/2008 | * | Xavier | 5 | at | North Carolina-Charlotte | 4 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/11/2008 | * | #1 Miami, Florida |
| at | #25 Georgia Tech |
| Postponed | | Recap | PPD to 4/12 |
| 4/11/2008 | * | #2 Florida State | 8 | at | Boston College | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #2 Florida State | 4 | at | Boston College | 3 | FINAL | Box Score | Recap | moved from 4/12, impending weather |
| 4/11/2008 | * | #4 North Carolina |
| at | #27 Clemson |
| Suspended | | Recap | Suspended to 4/12, inclement weather (5-0 UNC, top 7) |
| 4/11/2008 | * | #19 Virginia | 11 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Duke | 4 | at | North Carolina State | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Virginia Tech | 7 | at | Wake Forest | 3 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/11/2008 | * | Florida Gulf Coast | 6 | at | Lipscomb | 7 | FINAL | Box Score | Recap | 10 innings |
| 4/11/2008 | * | Gardner-Webb | 21 | at | East Tennessee State | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Jacksonville | 8 | at | Campbell | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Jacksonville | 1 | at | Campbell | 3 | FINAL | Box Score | Recap | moved from 4/12, impending weather |
| 4/11/2008 | * | Kennesaw State | 5 | at | South Carolina-Upstate | 14 | FINAL | Box Score | Recap | 250th career win for USCU's Matt Fincher |
| 4/11/2008 | * | Stetson |
| at | Belmont |
| Postponed | | Recap | PPD to 4/12, inclement weather |
| Big 10 Conference |
| 4/11/2008 | * | Iowa | 12 | at | Indiana | 13 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Michigan | 9 | at | Illinois | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Minnesota |
| at | Northwestern |
| Postponed | | Recap | PPD to 4/12, travel problems |
| 4/11/2008 | * | Ohio State | 4 | at | Michigan State | 3 | FINAL | Box Score | Recap | 11 innings |
| 4/11/2008 | * | Penn State | 8 | at | Purdue | 13 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/11/2008 | * | Oklahoma | 7 | at | #8 Texas A&M | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #11 Texas | 12 | at | #12 Missouri | 31 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #14 Nebraska | 0 | at | #20 Oklahoma State | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #30 Baylor | 1 | at | Kansas State | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Texas Tech | 5 | at | Kansas | 9 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/11/2008 | * | Connecticut | 2 | at | St. John's | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Louisville | 10 | at | South Florida | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Notre Dame | 2 | at | Villanova | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Pittsburgh | 3 | at | Cincinnati | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Rutgers | 22 | at | Georgetown | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | West Virginia | 4 | at | Seton Hall | 7 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/11/2008 | * | #21 Coastal Carolina | 14 | at | Charleston Southern | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | High Point | 4 | at | Winthrop | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Liberty | 5 | at | Radford | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | VMI |
| at | North Carolina-Asheville |
| Suspended | | Recap | Suspended to 4/12, rain (0-0, top 1) |
| Big West Conference |
| 4/11/2008 | * | #6 UC Irvine | 10 | at | #16 Long Beach State | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Cal State Northridge | 0 | at | #15 Cal State Fullerton | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Pacific | 3 | at | Cal Poly | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | UC Davis | 2 | at | UC Santa Barbara | 9 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| UC Riverside | 3 | at | UCLA | 5 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/11/2008 | * | Georgia State | 5 | at | #28 North Carolina-Wilmington | 6 | FINAL | Box Score | Recap | 11 innings |
| 4/11/2008 | * | Delaware | 5 | at | James Madison | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | George Mason | 7 | at | Hofstra | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Northeastern | 7 | at | Virginia Commonwealth | 15 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Northeastern | 12 | at | Virginia Commonwealth | 11 | FINAL | Box Score | Recap | 7 innings (moved from 3/12, impending weather) |
| 4/11/2008 | * | Old Dominion | 3 | at | Towson | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| New York Tech | 6 | at | William and Mary | 9 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/11/2008 | * | Alabama-Birmingham | 11 | at | #7 Rice | 13 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Marshall | 4 | at | East Carolina | 7 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Memphis | 6 | at | UCF | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Tulane | 3 | at | Houston | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Arkansas State | 3 | at | Southern Mississippi | 6 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/11/2008 |
| Montana State-Billings |
| at | Northern Colorado |
| Postponed | | Recap | PPD to 4/12, inclement weather |
| 4/11/2008 |
| New York Tech | 6 | at | William and Mary | 9 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Texas-Pan American | 17 | at | Texas Southern | 11 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Utah Valley State | 0 | at | Nevada | 1 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/11/2008 | * | Cleveland State | 6 | at | Wisconsin-Milwaukee | 7 | FINAL | Box Score | Recap | Chicago, IL (moved from UWM, field conditions) |
| 4/11/2008 | * | Cleveland State | 24 | at | Wisconsin-Milwaukee | 18 | FINAL | Box Score | Recap | Chicago, IL (moved from UWM, field conditions) |
| 4/11/2008 | * | Illinois-Chicago | 5 | at | Youngstown State | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/11/2008 | * | Wright State | 17 | at | Butler | 9 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/11/2008 | * | Akron | 4 | at | Northern Illinois | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Bowling Green State | 18 | at | Ball State | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Buffalo | 5 | at | Western Michigan | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Eastern Michigan | 15 | at | Ohio | 13 | FINAL | Box Score | Recap | 11 innings |
| 4/11/2008 | * | Miami, Ohio | 3 | at | Central Michigan | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Toledo | 5 | at | Kent State | 14 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/11/2008 | * | #5 Wichita State |
| at | Creighton |
| Postponed | | Recap | PPD to 4/13, inclement weather |
| 4/11/2008 |
| Indiana State | 2 | at | #22 Arizona | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Bradley | 7 | at | Southern Illinois | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/11/2008 | * | Evansville | 4 | at | Missouri State | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Northern Iowa | 2 | at | Illinois State | 1 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/11/2008 | * | Air Force | 1 | at | New Mexico | 7 | FINAL | Box Score | Recap | Farmington, NM |
| 4/11/2008 | * | Nevada-Las Vegas | 3 | at | Texas Christian | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Utah | 0 | at | San Diego State | 1 | FINAL | Box Score | Recap | 23 strikeouts for SDSU's Stephen Strasburg |
| 4/11/2008 |
| Brigham Young | 4 | at | Washington | 12 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/11/2008 | * | Central Connecticut State | 8 | at | Mount St. Mary's | 9 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Fairleigh Dickinson | 11 | at | Quinnipiac | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Fairleigh Dickinson | 4 | at | Quinnipiac | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/11/2008 | * | Monmouth | 5 | at | Wagner | 0 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Sacred Heart | 9 | at | Long Island | 2 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/11/2008 | * | #3 Arizona State | 15 | at | Washington State | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #17 California | 1 | at | Southern California | 17 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Indiana State | 2 | at | #22 Arizona | 10 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #26 Stanford | 9 | at | Oregon State | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/11/2008 |
| Brigham Young | 4 | at | Washington | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| UC Riverside | 3 | at | UCLA | 5 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/11/2008 | * | #9 Kentucky | 2 | at | #24 Georgia | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #10 South Carolina | 7 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | #13 Vanderbilt | 15 | at | Mississippi State | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Louisiana State | 1 | at | #23 Mississippi | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Arkansas | 2 | at | #29 Florida | 1 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Alabama |
| at | Tennessee |
| Postponed | | Recap | PPD to 4/12, rain |
| Southern Conference |
| 4/11/2008 | * | Appalachian State | 7 | at | Georgia Southern | 13 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | College of Charleston |
| at | Furman |
| Suspended | | Recap | Suspended to 4/12, inclement weather (10-8 Furman, bottom 8) |
| 4/11/2008 | * | Davidson | 3 | at | The Citadel | 9 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Western Carolina | 1 | at | Elon | 16 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Wofford | 2 | at | North Carolina-Greensboro | 3 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/11/2008 | * | Nicholls State | 7 | at | Central Arkansas | 8 | FINAL | Box Score | Recap | 11 innings |
| 4/11/2008 | * | Sam Houston State | 14 | at | Lamar | 3 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/11/2008 | * | Texas A&M-Corpus Christi | 11 | at | Stephen F. Austin | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Texas State | 3 | at | Southeastern Louisiana | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Texas-Arlington | 7 | at | McNeese State | 2 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Texas-San Antonio | 10 | at | Northwestern State | 4 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/11/2008 | * | Alabama A&M | 5 | at | Jackson State | 14 | FINAL | Box Score | Recap | 7 innings |
| 4/11/2008 | * | Jackson State | 11 | vs | Alabama A&M | 4 | FINAL | Box Score | Recap | makeup of 3/8 game (7 innings (Jackson, MS)) |
| 4/11/2008 |
| Texas-Pan American | 17 | at | Texas Southern | 11 | FINAL | Box Score | Recap | |
| Summit League |
| 4/11/2008 | * | IUPU-Fort Wayne |
| at | Western Illinois |
| Postponed | | | PPD to 4/14, inclement weather |
| 4/11/2008 | * | IUPU-Fort Wayne |
| at | Western Illinois |
| Postponed | | | PPD to 4/14, inclement weather |
| 4/11/2008 | * | Oral Roberts | 10 | at | Centenary | 9 | FINAL | Box Score | Recap | 16 innings |
| 4/11/2008 | * | South Dakota State | 8 | at | Oakland | 5 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Southern Utah |
| at | North Dakota State |
| Postponed | | Recap | PPD to 4/13, inclement weather |
| Sun Belt Conference |
| 4/11/2008 | * | Louisiana-Monroe | 10 | at | Louisiana-Lafayette | 12 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Middle Tennessee State | 7 | at | Florida International | 3 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | South Alabama |
| at | Arkansas-Little Rock |
| Postponed | | Recap | PPD to 4/12, field conditions |
| 4/11/2008 | * | Troy | 5 | at | Florida Atlantic | 6 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Western Kentucky | 10 | at | New Orleans | 11 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Arkansas State | 3 | at | Southern Mississippi | 6 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/11/2008 | * | #18 San Diego | 8 | at | Portland | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | San Francisco | 2 | at | Pepperdine | 11 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | Santa Clara | 12 | at | Gonzaga | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | St. Mary's | 14 | at | Loyola Marymount | 9 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/11/2008 | * | Louisiana Tech | 5 | at | Fresno State | 14 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | New Mexico State | 3 | at | Hawaii | 8 | FINAL | Box Score | Recap | |
| 4/11/2008 | * | San Jose State | 9 | at | Cal State Sacramento | 4 | FINAL | Box Score | Recap | |
| 4/11/2008 |
| Utah Valley State | 0 | at | Nevada | 1 | FINAL | Box Score | Recap | |