| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/12/2008 | * | #1 Miami, Florida | 10 | at | #25 Georgia Tech | 5 | FINAL | Box Score | Recap | makeup of 4/11 game |
| 4/12/2008 | * | #1 Miami, Florida | 15 | at | #25 Georgia Tech | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #2 Florida State | 17 | at | Boston College | 2 | FINAL | Box Score | Recap | moved from 4/13 |
| 4/12/2008 | * | #3 Arizona State | 4 | at | Washington State | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #4 North Carolina | 8 | at | #27 Clemson | 2 | FINAL | Box Score | Recap | Resumption of 4/11 game |
| 4/12/2008 | * | #4 North Carolina | 4 | at | #27 Clemson | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #5 Wichita State | 3 | at | Creighton | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #6 UC Irvine | 1 | at | #16 Long Beach State | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Alabama-Birmingham | 4 | at | #7 Rice | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Oklahoma | 3 | at | #8 Texas A&M | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #9 Kentucky | 4 | at | #24 Georgia | 13 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #10 South Carolina | 8 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #11 Texas | 2 | at | #12 Missouri | 13 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #13 Vanderbilt | 16 | at | Mississippi State | 0 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #14 Nebraska | 2 | at | #20 Oklahoma State | 19 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Cal State Northridge | 4 | at | #15 Cal State Fullerton | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #17 California | 5 | at | Southern California | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #18 San Diego | 5 | at | Portland | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #19 Virginia | 5 | at | Maryland | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #21 Coastal Carolina | 15 | at | Charleston Southern | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #21 Coastal Carolina | 11 | at | Charleston Southern | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Indiana State | 0 | at | #22 Arizona | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Louisiana State | 1 | at | #23 Mississippi | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #26 Stanford | 6 | at | Oregon State | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Georgia State | 9 | at | #28 North Carolina-Wilmington | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Arkansas | 1 | at | #29 Florida | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #30 Baylor | 5 | at | Kansas State | 4 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/12/2008 | * | Albany | 5 | at | Maine | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Albany | 8 | at | Maine | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Hartford | 5 | at | Stony Brook | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Hartford | 6 | at | Stony Brook | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Maryland-Baltimore County | 2 | at | Binghamton | 13 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Maryland-Baltimore County | 9 | at | Binghamton | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| Vermont | 3 | at | New Jersey Tech | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| Vermont | 11 | at | New Jersey Tech | 3 | FINAL | Box Score | Recap | 7 innings |
| Atlantic 10 Conference |
| 4/12/2008 | * | George Washington | 9 | at | Fordham | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | LaSalle | 8 | at | Duquesne | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | LaSalle | 0 | at | Duquesne | 3 | FINAL | Box Score | Recap | moved from 4/13, impending weather |
| 4/12/2008 | * | Massachusetts | 6 | at | St. Bonaventure | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Massachusetts | 3 | at | St. Bonaventure | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Richmond | 2 | at | Temple | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | St. Joseph's | 4 | at | Dayton | 5 | FINAL | Box Score | Recap | 11 innings |
| 4/12/2008 | * | St. Joseph's | 4 | at | Dayton | 6 | FINAL | Box Score | Recap | moved from 4/13, impending weather |
| 4/12/2008 | * | Xavier | 5 | at | North Carolina-Charlotte | 6 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/12/2008 | * | #1 Miami, Florida | 10 | at | #25 Georgia Tech | 5 | FINAL | Box Score | Recap | makeup of 4/11 game |
| 4/12/2008 | * | #1 Miami, Florida | 15 | at | #25 Georgia Tech | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #2 Florida State | 17 | at | Boston College | 2 | FINAL | Box Score | Recap | moved from 4/13 |
| 4/12/2008 | * | #4 North Carolina | 8 | at | #27 Clemson | 2 | FINAL | Box Score | Recap | Resumption of 4/11 game |
| 4/12/2008 | * | #4 North Carolina | 4 | at | #27 Clemson | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #19 Virginia | 5 | at | Maryland | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Duke | 1 | at | North Carolina State | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Virginia Tech | 13 | at | Wake Forest | 4 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/12/2008 | * | Florida Gulf Coast | 1 | at | Lipscomb | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Florida Gulf Coast | 10 | at | Lipscomb | 9 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Gardner-Webb | 18 | at | East Tennessee State | 16 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Gardner-Webb | 7 | at | East Tennessee State | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/12/2008 | * | Jacksonville | 4 | at | Campbell | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Kennesaw State | 11 | at | South Carolina-Upstate | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Kennesaw State | 32 | at | South Carolina-Upstate | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | North Florida | 6 | at | Mercer | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | North Florida | 4 | at | Mercer | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Stetson | 6 | at | Belmont | 13 | FINAL | Box Score | Recap | makeup of 4/11 game |
| 4/12/2008 | * | Stetson | 5 | at | Belmont | 11 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/12/2008 | * | Iowa | 12 | at | Indiana | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Iowa | 13 | at | Indiana | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Michigan | 14 | at | Illinois | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Michigan | 14 | at | Illinois | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Minnesota |
| at | Northwestern |
| Postponed | | Recap | PPD to 4/14, rain (makeup of 4/11 game) |
| 4/12/2008 | * | Ohio State |
| at | Michigan State |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Ohio State |
| at | Michigan State |
| Canceled | | Recap | CCD, rain |
| 4/12/2008 | * | Penn State | 4 | at | Purdue | 12 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Penn State | 1 | at | Purdue | 4 | FINAL | Box Score | Recap | 7 innings |
| Big 12 Conference |
| 4/12/2008 | * | Oklahoma | 3 | at | #8 Texas A&M | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #11 Texas | 2 | at | #12 Missouri | 13 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #14 Nebraska | 2 | at | #20 Oklahoma State | 19 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #30 Baylor | 5 | at | Kansas State | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Texas Tech | 1 | at | Kansas | 9 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/12/2008 | * | Connecticut | 5 | at | St. John's | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Louisville | 10 | at | South Florida | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Notre Dame | 8 | at | Villanova | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Pittsburgh | 2 | at | Cincinnati | 3 | FINAL | Box Score | Recap | 11 innings |
| 4/12/2008 | * | Rutgers | 5 | at | Georgetown | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | West Virginia | 3 | at | Seton Hall | 4 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/12/2008 | * | #21 Coastal Carolina | 15 | at | Charleston Southern | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #21 Coastal Carolina | 11 | at | Charleston Southern | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | High Point | 4 | at | Winthrop | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Liberty | 18 | at | Radford | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | VMI | 5 | at | North Carolina-Asheville | 8 | FINAL | Box Score | Recap | Resumption of 4/11 game |
| 4/12/2008 | * | VMI | 7 | at | North Carolina-Asheville | 4 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/12/2008 | * | #6 UC Irvine | 1 | at | #16 Long Beach State | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Cal State Northridge | 4 | at | #15 Cal State Fullerton | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Pacific | 4 | at | Cal Poly | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | UC Davis | 16 | at | UC Santa Barbara | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| UC Riverside | 7 | at | UCLA | 18 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/12/2008 | * | Georgia State | 9 | at | #28 North Carolina-Wilmington | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Delaware | 7 | at | James Madison | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | George Mason | 10 | at | Hofstra | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Northeastern | 2 | at | Virginia Commonwealth | 16 | FINAL | Box Score | Recap | moved from 4/13 |
| 4/12/2008 | * | Old Dominion | 9 | at | Towson | 12 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| New York Tech | 9 | at | William and Mary | 15 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| New York Tech | 2 | at | William and Mary | 7 | FINAL | Box Score | Recap | 7 innings |
| Conference USA |
| 4/12/2008 | * | Alabama-Birmingham | 4 | at | #7 Rice | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Marshall | 3 | at | East Carolina | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Memphis | 8 | at | UCF | 7 | FINAL | Box Score | Recap | 11 innings |
| 4/12/2008 | * | Tulane | 7 | at | Houston | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Arkansas State | 7 | at | Southern Mississippi | 8 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/12/2008 |
| Chicago State |
| at | Valparaiso |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 |
| Chicago State |
| at | Valparaiso |
| Postponed | | Recap | PPD, rain |
| 4/12/2008 |
| LeMoyne | 20 | at | St. Peter's | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| LeMoyne | 29 | at | St. Peter's | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| Montana State-Billings | 8 | at | Northern Colorado | 19 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| New York Tech | 9 | at | William and Mary | 15 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| New York Tech | 2 | at | William and Mary | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| North Carolina Central |
| at | Virginia State |
| Canceled | | | CCD, rain |
| 4/12/2008 |
| North Carolina Central |
| at | Virginia State |
| Canceled | | | CCD, rain |
| 4/12/2008 |
| Savannah State | 7 | at | Presbyterian | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Texas-Pan American | 17 | at | Texas Southern | 12 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Utah Valley State | 1 | at | Nevada | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Utah Valley State | 3 | at | Nevada | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Vermont | 3 | at | New Jersey Tech | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| Vermont | 11 | at | New Jersey Tech | 3 | FINAL | Box Score | Recap | 7 innings |
| Horizon League |
| 4/12/2008 | * | Cleveland State |
| at | Wisconsin-Milwaukee |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Illinois-Chicago | 3 | at | Youngstown State | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Illinois-Chicago | 9 | at | Youngstown State | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Wright State | 5 | at | Butler | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Wright State | 4 | at | Butler | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Chicago State |
| at | Valparaiso |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 |
| Chicago State |
| at | Valparaiso |
| Postponed | | Recap | PPD, rain |
| Ivy League |
| 4/12/2008 | * | Cornell | 2 | at | Pennsylvania | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Cornell |
| at | Pennsylvania |
| Suspended | | Recap | Suspended to 4/13, darkness (6-6, bottom 8) |
| 4/12/2008 | * | Dartmouth | 8 | at | Brown | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Dartmouth | 6 | at | Brown | 18 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Harvard | 1 | at | Yale | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Harvard | 12 | at | Yale | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Princeton | 10 | at | Columbia | 9 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Princeton | 13 | at | Columbia | 7 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/12/2008 | * | Canisius | 6 | at | Marist | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Canisius | 6 | at | Marist | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Fairfield | 6 | at | Siena | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Fairfield | 6 | at | Siena | 20 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Manhattan |
| at | Niagara |
| Postponed | | Recap | PPD to 4/13, field conditions |
| 4/12/2008 | * | Niagara | 4 | at | Manhattan | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Rider | 6 | at | Iona | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Rider |
| at | Iona |
| Postponed | | Recap | PPD to 4/13, field conditions |
| 4/12/2008 |
| LeMoyne | 20 | at | St. Peter's | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| LeMoyne | 29 | at | St. Peter's | 7 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 4/12/2008 | * | Akron |
| at | Northern Illinois |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Bowling Green State | 18 | at | Ball State | 16 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Buffalo |
| at | Western Michigan |
| Postponed | | Recap | PPD to 4/13, inclement weather |
| 4/12/2008 | * | Eastern Michigan | 13 | at | Ohio | 12 | FINAL | Box Score | Recap | 10 innings |
| 4/12/2008 | * | Miami, Ohio | 4 | at | Central Michigan | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Miami, Ohio |
| at | Central Michigan |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Toledo | 2 | at | Kent State | 5 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/12/2008 | * | Florida A&M |
| at | Delaware State |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Florida A&M |
| at | Delaware State |
| Postponed | | Recap | PPD to 4/13, rain |
| 4/12/2008 | * | Norfolk State | 1 | at | Bethune-Cookman | 10 | FINAL | Box Score | Recap | Ormond Beach, FL |
| 4/12/2008 | * | Norfolk State | 0 | at | Bethune-Cookman | 3 | FINAL | Box Score | Recap | 7 innings (Ormond Beach, FL) |
| 4/12/2008 | * | North Carolina A&T |
| at | Maryland-Eastern Shore |
| Suspended | | Recap | Suspended to 4/13, inclement weather (0-0, top 2) |
| 4/12/2008 | * | North Carolina A&T |
| at | Maryland-Eastern Shore |
| Postponed | | Recap | PPD, inclement weather |
| Missouri Valley Conference |
| 4/12/2008 | * | #5 Wichita State | 3 | at | Creighton | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Indiana State | 0 | at | #22 Arizona | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Bradley | 4 | at | Southern Illinois | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Evansville | 1 | at | Missouri State | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Northern Iowa | 11 | at | Illinois State | 7 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/12/2008 | * | Air Force | 9 | at | New Mexico | 26 | FINAL | Box Score | Recap | 4 HR for NM's Brian Cavazos-Galvez (Farmington, NM) |
| 4/12/2008 | * | Nevada-Las Vegas | 1 | at | Texas Christian | 12 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Utah | 2 | at | San Diego State | 9 | FINAL | Box Score | Recap | SDSU's Pat Colwell hits for cycle |
| 4/12/2008 |
| Brigham Young | 11 | at | Washington | 7 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/12/2008 | * | Central Connecticut State | 2 | at | Mount St. Mary's | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Central Connecticut State | 5 | at | Mount St. Mary's | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Fairleigh Dickinson | 2 | at | Quinnipiac | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Fairleigh Dickinson | 4 | at | Quinnipiac | 14 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Monmouth | 1 | at | Wagner | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Monmouth | 3 | at | Wagner | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Sacred Heart | 1 | at | Long Island | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Sacred Heart | 5 | at | Long Island | 12 | FINAL | Box Score | Recap | 7 innings |
| Ohio Valley Conference |
| 4/12/2008 | * | Austin Peay State | 3 | at | Samford | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Austin Peay State | 1 | at | Samford | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Eastern Illinois | 4 | at | Murray State | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Eastern Illinois | 3 | at | Murray State | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Eastern Kentucky | 6 | at | Tennessee-Martin | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Eastern Kentucky | 6 | at | Tennessee-Martin | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Morehead State | 5 | at | Tennessee Tech | 9 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Morehead State | 3 | at | Tennessee Tech | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Southeast Missouri State | 6 | at | Jacksonville State | 16 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Southeast Missouri State | 3 | at | Jacksonville State | 4 | FINAL | Box Score | Recap | 7 innings |
| Pac 10 Conference |
| 4/12/2008 | * | #3 Arizona State | 4 | at | Washington State | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #17 California | 5 | at | Southern California | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Indiana State | 0 | at | #22 Arizona | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #26 Stanford | 6 | at | Oregon State | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Brigham Young | 11 | at | Washington | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| UC Riverside | 7 | at | UCLA | 18 | FINAL | Box Score | Recap | |
| Patriot League |
| 4/12/2008 | * | Army | 14 | at | Navy | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Army |
| at | Navy |
| Postponed | | Recap | PPD to 4/14, inclement weather |
| 4/12/2008 | * | Holy Cross | 4 | at | Bucknell | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Holy Cross | 8 | at | Bucknell | 0 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Lafayette | 1 | at | Lehigh | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Lafayette | 5 | at | Lehigh | 0 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/12/2008 | * | #9 Kentucky | 4 | at | #24 Georgia | 13 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #10 South Carolina | 8 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | #13 Vanderbilt | 16 | at | Mississippi State | 0 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Louisiana State | 1 | at | #23 Mississippi | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Arkansas | 1 | at | #29 Florida | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Alabama | 11 | at | Tennessee | 10 | FINAL | Box Score | Recap | makeup of 4/11 game |
| 4/12/2008 | * | Alabama | 5 | at | Tennessee | 13 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/12/2008 | * | Appalachian State | 5 | at | Georgia Southern | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | College of Charleston | 9 | at | Furman | 11 | FINAL | Box Score | Recap | Resumption of 4/11 game |
| 4/12/2008 | * | College of Charleston | 3 | at | Furman | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Davidson | 1 | at | The Citadel | 9 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Western Carolina | 2 | at | Elon | 3 | FINAL | Box Score | Recap | 11 innings |
| 4/12/2008 | * | Wofford | 9 | at | North Carolina-Greensboro | 16 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/12/2008 | * | Nicholls State | 4 | at | Central Arkansas | 14 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/12/2008 | * | Sam Houston State | 9 | at | Lamar | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Texas A&M-Corpus Christi | 9 | at | Stephen F. Austin | 7 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Texas State | 11 | at | Southeastern Louisiana | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Texas-Arlington | 10 | at | McNeese State | 8 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Texas-San Antonio | 11 | at | Northwestern State | 9 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/12/2008 | * | Alabama A&M | 5 | at | Jackson State | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Alabama A&M | 4 | at | Jackson State | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Alcorn State | 15 | at | Alabama State | 6 | FINAL | Box Score | | |
| 4/12/2008 | * | Arkansas-Pine Bluff | 8 | at | Southern | 21 | FINAL | Box Score | | 7 innings |
| 4/12/2008 | * | Arkansas-Pine Bluff | 5 | at | Southern | 12 | FINAL | Box Score | | 7 innings |
| 4/12/2008 | * | Prairie View A&M | 5 | at | Grambling State | 9 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | Prairie View A&M | 15 | at | Grambling State | 12 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 |
| Texas-Pan American | 17 | at | Texas Southern | 12 | FINAL | Box Score | Recap | |
| Summit League |
| 4/12/2008 | * | Oral Roberts | 8 | at | Centenary | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Oral Roberts | 7 | at | Centenary | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | South Dakota State |
| at | Oakland |
| Postponed | | Recap | PPD to 4/13, inclement weather |
| 4/12/2008 | * | South Dakota State |
| at | Oakland |
| Canceled | | Recap | CCD, inclement weather |
| 4/12/2008 | * | Southern Utah | 12 | at | North Dakota State | 5 | FINAL | Box Score | Recap | 17 innings |
| 4/12/2008 | * | Southern Utah |
| at | North Dakota State |
| Canceled | | Recap | CCD, field conditions |
| Sun Belt Conference |
| 4/12/2008 | * | Louisiana-Monroe | 15 | at | Louisiana-Lafayette | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Middle Tennessee State | 9 | at | Florida International | 7 | FINAL | Box Score | Recap | 10 innings |
| 4/12/2008 | * | South Alabama | 10 | at | Arkansas-Little Rock | 11 | FINAL | Box Score | Recap | makeup of 4/11 game |
| 4/12/2008 | * | South Alabama | 10 | at | Arkansas-Little Rock | 1 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Troy | 7 | at | Florida Atlantic | 2 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Western Kentucky | 3 | at | New Orleans | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Arkansas State | 7 | at | Southern Mississippi | 8 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/12/2008 | * | #18 San Diego | 5 | at | Portland | 4 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | San Francisco | 10 | at | Pepperdine | 11 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Santa Clara | 4 | at | Gonzaga | 5 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | St. Mary's | 9 | at | Loyola Marymount | 15 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/12/2008 | * | Louisiana Tech | 8 | at | Fresno State | 9 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | Louisiana Tech | 1 | at | Fresno State | 11 | FINAL | Box Score | Recap | 7 innings |
| 4/12/2008 | * | New Mexico State | 9 | at | Hawaii | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | New Mexico State | 1 | at | Hawaii | 5 | FINAL | Box Score | Recap | 200th career win for UH's Mke Trapasso |
| 4/12/2008 | * | San Jose State | 3 | at | Cal State Sacramento | 6 | FINAL | Box Score | Recap | |
| 4/12/2008 | * | San Jose State | 9 | at | Cal State Sacramento | 10 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Utah Valley State | 1 | at | Nevada | 3 | FINAL | Box Score | Recap | |
| 4/12/2008 |
| Utah Valley State | 3 | at | Nevada | 11 | FINAL | Box Score | Recap | |