| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/16/2008 |
| #1 Miami, Florida | 12 | at | Florida Atlantic | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Florida | 2 | at | #2 Florida State | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Carolina-Charlotte | 4 | at | #4 North Carolina | 5 | FINAL | Box Score | Recap | 12 innings |
| 4/16/2008 |
| #9 South Carolina | 6 | at | Clemson | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| William Woods | 9 | at | #10 Missouri | 16 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #11 Vanderbilt | 5 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Mid-America Christian | 1 | at | #14 Oklahoma State | 25 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Texas-Arlington | 4 | at | #15 Texas | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Morehead State | 5 | at | #17 Kentucky | 6 | FINAL | Box Score | Recap | makeup of 3/19 game |
| 4/16/2008 |
| #19 Coastal Carolina | 12 | at | Elon | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Georgia State | 5 | at | #21 Georgia | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #22 Arizona | 4 | at | New Mexico | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| San Francisco | 10 | at | #25 Stanford | 11 | FINAL | Box Score | Recap | 11 innings |
| 4/16/2008 |
| The Citadel | 3 | at | #26 East Carolina | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| Eastern Michigan | 5 | at | #27 Michigan | 20 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #28 Georgia Tech | 14 | at | Georgia Southern | 8 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/16/2008 |
| Hartford | 3 | at | Rhode Island | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Maine | 13 | at | Coppin State | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Vermont | 10 | at | Quinnipiac | 7 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/16/2008 |
| North Carolina-Charlotte | 4 | at | #4 North Carolina | 5 | FINAL | Box Score | Recap | 12 innings |
| 4/16/2008 |
| Canisius | 2 | at | St. Bonaventure | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Canisius | 11 | at | St. Bonaventure | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Eastern Illinois | 2 | at | St. Louis | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/16/2008 |
| Fordham | 9 | at | Columbia | 8 | FINAL | Box Score | Recap | 8 innings |
| 4/16/2008 |
| Fordham | 1 | at | Columbia | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| George Mason | 2 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Hartford | 3 | at | Rhode Island | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| LaSalle | 8 | at | Pennsylvania | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Massachusetts | 4 | at | Boston College | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Pittsburgh | 17 | vs | Duquesne | 6 | FINAL | Box Score | Recap | Pittsburgh, PA (PNC Park) |
| 4/16/2008 |
| Towson | 13 | at | George Washington | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Wright State | 10 | at | Dayton | 12 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| Xavier | 2 | at | Miami, Ohio | 7 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/16/2008 |
| #1 Miami, Florida | 12 | at | Florida Atlantic | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Florida | 2 | at | #2 Florida State | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Carolina-Charlotte | 4 | at | #4 North Carolina | 5 | FINAL | Box Score | Recap | 12 innings |
| 4/16/2008 |
| #9 South Carolina | 6 | at | Clemson | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #28 Georgia Tech | 14 | at | Georgia Southern | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Duke | 16 | at | Campbell | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Maryland-Eastern Shore | 1 | at | Maryland | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Massachusetts | 4 | at | Boston College | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Radford | 2 | at | North Carolina State | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Virginia Tech | 11 | at | Liberty | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Winthrop | 8 | at | Wake Forest | 10 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/16/2008 |
| North Florida | 2 | at | #2 Florida State | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Appalachian State | 1 | at | East Tennessee State | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Cumberlands (KY) | 4 | at | Belmont | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Duke | 16 | at | Campbell | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Gardner-Webb | 4 | at | North Carolina A&T | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Jacksonville | 9 | at | Florida A&M | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Kennesaw State | 4 | at | Alabama-Birmingham | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Savannah State | 1 | at | Mercer | 27 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/16/2008 |
| Eastern Michigan | 5 | at | #27 Michigan | 20 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Ball State | 5 | at | Indiana | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Central Michigan | 10 | at | Michigan State | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Iowa | 8 | at | Creighton | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Louisville | 13 | at | Ohio State | 12 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Minnesota | 8 | at | Northern Iowa | 9 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/16/2008 |
| William Woods | 9 | at | #10 Missouri | 16 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Mid-America Christian | 1 | at | #14 Oklahoma State | 25 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Texas-Arlington | 4 | at | #15 Texas | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Baylor | 5 | at | Dallas Baptist | 13 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Missouri State | 6 | at | Kansas | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Southern Nazarene | 3 | at | Oklahoma | 15 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/16/2008 |
| Texas Tech | 8 | at | Nevada-Las Vegas | 15 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/16/2008 |
| Cincinnati | 7 | at | Butler | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Connecticut | 10 | at | Brown | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Hofstra | 5 | at | St. John's | 19 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Iona | 7 | at | Rutgers | 16 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Lafayette | 6 | at | Villanova | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Louisville | 13 | at | Ohio State | 12 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Navy | 2 | at | Georgetown | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Notre Dame | 5 | vs | Northern Illinois | 4 | FINAL | Box Score | Recap | Chicago, IL |
| 4/16/2008 |
| Pittsburgh | 17 | vs | Duquesne | 6 | FINAL | Box Score | Recap | Pittsburgh, PA (PNC Park) |
| 4/16/2008 |
| South Florida | 7 | at | Bethune-Cookman | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Wagner | 2 | at | Seton Hall | 3 | FINAL | Box Score | Recap | 10 innings |
| Big South Conference |
| 4/16/2008 |
| #19 Coastal Carolina | 12 | at | Elon | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| College of Charleston | 5 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | Resumption of 4/1 game |
| 4/16/2008 |
| College of Charleston | 4 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Norfolk State | 7 | at | VMI | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Carolina-Asheville | 13 | at | Furman | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Radford | 2 | at | North Carolina State | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Virginia Tech | 11 | at | Liberty | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Winthrop | 8 | at | Wake Forest | 10 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/16/2008 |
| Loyola Marymount | 3 | at | Cal Poly | 10 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/16/2008 |
| Georgia State | 5 | at | #21 Georgia | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| George Mason | 2 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Hofstra | 5 | at | St. John's | 19 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Towson | 13 | at | George Washington | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| William and Mary | 13 | at | Longwood | 8 | FINAL | Box Score | Recap | 10 innings |
| Conference USA |
| 4/16/2008 |
| The Citadel | 3 | at | #26 East Carolina | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| Kennesaw State | 4 | at | Alabama-Birmingham | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Memphis | 7 | vs | Tennessee-Martin | 3 | FINAL | Box Score | Recap | Jackson, TN |
| 4/16/2008 |
| Sam Houston State | 6 | at | Houston | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Southern Mississippi | 6 | vs | Alabama | 3 | FINAL | Box Score | Recap | Pearl, MS |
| Division I Independents |
| 4/16/2008 |
| Baylor | 5 | at | Dallas Baptist | 13 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Chicago State | 5 | vs | Oakland | 11 | FINAL | Box Score | Recap | South Bend, IN |
| 4/16/2008 |
| New Jersey Tech | 1 | at | Rider | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| New York Tech | 0 | at | Siena | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| New York Tech | 1 | at | Siena | 10 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Savannah State | 1 | at | Mercer | 27 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Texas-Pan American | 0 | at | Texas State | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| William and Mary | 13 | at | Longwood | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| Wofford | 10 | at | Presbyterian | 2 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/16/2008 |
| Cincinnati | 7 | at | Butler | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Cleveland State | 5 | at | Niagara | 12 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Ohio | 14 | at | Youngstown State | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| St. Francis (IN) | 9 | at | Valparaiso | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| Wright State | 10 | at | Dayton | 12 | FINAL | Box Score | Recap | 10 innings |
| Ivy League |
| 4/16/2008 |
| Connecticut | 10 | at | Brown | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Fairfield | 0 | at | Yale | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Fairfield | 2 | at | Yale | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Fordham | 9 | at | Columbia | 8 | FINAL | Box Score | Recap | 8 innings |
| 4/16/2008 |
| Fordham | 1 | at | Columbia | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Holy Cross | 5 | at | Dartmouth | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| LaSalle | 8 | at | Pennsylvania | 2 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/16/2008 |
| Canisius | 2 | at | St. Bonaventure | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Canisius | 11 | at | St. Bonaventure | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Cleveland State | 5 | at | Niagara | 12 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Fairfield | 0 | at | Yale | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Fairfield | 2 | at | Yale | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| Fairleigh Dickinson | 15 | at | St. Peter's | 20 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Iona | 7 | at | Rutgers | 16 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Manhattan | 14 | at | Sacred Heart | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Marist | 7 | at | Army | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| New Jersey Tech | 1 | at | Rider | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| New York Tech | 0 | at | Siena | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/16/2008 |
| New York Tech | 1 | at | Siena | 10 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 4/16/2008 |
| Eastern Michigan | 5 | at | #27 Michigan | 20 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Akron | 15 | vs | Kent State | 16 | FINAL | Box Score | Recap | Akron, OH (Canal Park) |
| 4/16/2008 |
| Ball State | 5 | at | Indiana | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Bowling Green State | 15 | at | Toledo | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Central Michigan | 10 | at | Michigan State | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| IUPU-Fort Wayne | 5 | at | Western Michigan | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Notre Dame | 5 | vs | Northern Illinois | 4 | FINAL | Box Score | Recap | Chicago, IL |
| 4/16/2008 |
| Ohio | 14 | at | Youngstown State | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Xavier | 2 | at | Miami, Ohio | 7 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/16/2008 |
| Delaware State | 5 | at | Lehigh | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Gardner-Webb | 4 | at | North Carolina A&T | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Jacksonville | 9 | at | Florida A&M | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Maine | 13 | at | Coppin State | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Maryland-Eastern Shore | 1 | at | Maryland | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Norfolk State | 7 | at | VMI | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| South Florida | 7 | at | Bethune-Cookman | 6 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/16/2008 |
| Iowa | 8 | at | Creighton | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Minnesota | 8 | at | Northern Iowa | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Missouri State | 6 | at | Kansas | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Oakland City | 0 | at | Evansville | 5 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Robert Morris | 9 | at | Illinois State | 12 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/16/2008 |
| #22 Arizona | 4 | at | New Mexico | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Colorado Christian |
| at | Air Force |
| Suspended | | Recap | Suspended, snow (1-0 CC, top 3) |
| 4/16/2008 |
| Texas Tech | 8 | at | Nevada-Las Vegas | 15 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/16/2008 |
| Fairleigh Dickinson | 15 | at | St. Peter's | 20 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Manhattan | 14 | at | Sacred Heart | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Vermont | 10 | at | Quinnipiac | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Wagner | 2 | at | Seton Hall | 3 | FINAL | Box Score | Recap | 10 innings |
| Ohio Valley Conference |
| 4/16/2008 |
| Morehead State | 5 | at | #17 Kentucky | 6 | FINAL | Box Score | Recap | makeup of 3/19 game |
| 4/16/2008 |
| Alabama State | 6 | at | Jacksonville State | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Austin Peay State | 9 | at | Middle Tennessee State | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Eastern Illinois | 2 | at | St. Louis | 3 | FINAL | Box Score | Recap | 12 innings |
| 4/16/2008 |
| Memphis | 7 | vs | Tennessee-Martin | 3 | FINAL | Box Score | Recap | Jackson, TN |
| 4/16/2008 |
| Murray State | 2 | at | Arkansas State | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Samford | 1 | at | Troy | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Thomas More | 6 | at | Eastern Kentucky | 16 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/16/2008 |
| #22 Arizona | 4 | at | New Mexico | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| San Francisco | 10 | at | #25 Stanford | 11 | FINAL | Box Score | Recap | 11 innings |
| Patriot League |
| 4/16/2008 |
| Delaware State | 5 | at | Lehigh | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Holy Cross | 5 | at | Dartmouth | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Lafayette | 6 | at | Villanova | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Marist | 7 | at | Army | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Navy | 2 | at | Georgetown | 6 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/16/2008 |
| #9 South Carolina | 6 | at | Clemson | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #11 Vanderbilt | 5 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Morehead State | 5 | at | #17 Kentucky | 6 | FINAL | Box Score | Recap | makeup of 3/19 game |
| 4/16/2008 |
| Georgia State | 5 | at | #21 Georgia | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Alcorn State | 1 | at | Arkansas | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Louisiana State | 5 | at | New Orleans | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| South Alabama | 7 | at | Auburn | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Southern Mississippi | 6 | vs | Alabama | 3 | FINAL | Box Score | Recap | Pearl, MS |
| Southern Conference |
| 4/16/2008 |
| #19 Coastal Carolina | 12 | at | Elon | 0 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| The Citadel | 3 | at | #26 East Carolina | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/16/2008 |
| #28 Georgia Tech | 14 | at | Georgia Southern | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Appalachian State | 1 | at | East Tennessee State | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| College of Charleston | 5 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | Resumption of 4/1 game |
| 4/16/2008 |
| College of Charleston | 4 | at | Charleston Southern | 2 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| North Carolina-Asheville | 13 | at | Furman | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Wofford | 10 | at | Presbyterian | 2 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/16/2008 |
| Texas-Arlington | 4 | at | #15 Texas | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| McNeese State | 9 | at | Louisiana-Monroe | 21 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Mississippi Valley State | 3 | at | Southeastern Louisiana | 15 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Nicholls State | 10 | at | Southern | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Northwestern State | 3 | at | Louisiana-Lafayette | 4 | FINAL | Box Score | Recap | 500th win at ULL for Tony Robichaux (makeup of 3/18 game) |
| 4/16/2008 |
| Sam Houston State | 6 | at | Houston | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Texas-Pan American | 0 | at | Texas State | 8 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Texas-San Antonio | 1 | at | Lamar | 2 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/16/2008 |
| Alabama A&M |
| at | Western Illinois |
| Canceled | | Recap | CCD, travel conflict |
| 4/16/2008 |
| Alabama State | 6 | at | Jacksonville State | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Alcorn State | 1 | at | Arkansas | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Arkansas-Pine Bluff | 6 | at | Jackson State | 13 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Mississippi Valley State | 3 | at | Southeastern Louisiana | 15 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Nicholls State | 10 | at | Southern | 14 | FINAL | Box Score | Recap | |
| Summit League |
| 4/16/2008 |
| Alabama A&M |
| at | Western Illinois |
| Canceled | | Recap | CCD, travel conflict |
| 4/16/2008 |
| Chicago State | 5 | vs | Oakland | 11 | FINAL | Box Score | Recap | South Bend, IN |
| 4/16/2008 |
| IUPU-Fort Wayne | 5 | at | Western Michigan | 14 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Wiley |
| at | Centenary |
| Canceled | | Recap | CCD, travel problems |
| Sun Belt Conference |
| 4/16/2008 |
| #1 Miami, Florida | 12 | at | Florida Atlantic | 10 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| #11 Vanderbilt | 5 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Austin Peay State | 9 | at | Middle Tennessee State | 11 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Louisiana State | 5 | at | New Orleans | 6 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| McNeese State | 9 | at | Louisiana-Monroe | 21 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Murray State | 2 | at | Arkansas State | 3 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Northwestern State | 3 | at | Louisiana-Lafayette | 4 | FINAL | Box Score | Recap | 500th win at ULL for Tony Robichaux (makeup of 3/18 game) |
| 4/16/2008 |
| Samford | 1 | at | Troy | 9 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| South Alabama | 7 | at | Auburn | 1 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/16/2008 |
| San Francisco | 10 | at | #25 Stanford | 11 | FINAL | Box Score | Recap | 11 innings |
| 4/16/2008 |
| Lewis and Clark | 0 | at | Portland | 7 | FINAL | Box Score | Recap | |
| 4/16/2008 |
| Loyola Marymount | 3 | at | Cal Poly | 10 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/16/2008 |
| Panhandle State | 9 | at | New Mexico State | 19 | FINAL | Box Score | Recap | 7 innings, run rule |