| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/18/2008 | * | #1 Miami, Florida | 11 | at | #2 Florida State | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Oregon State | 6 | at | #3 Arizona State | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Boston College | 3 | at | #4 North Carolina | 12 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | UC Riverside | 2 | at | #5 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Southern Illinois | 0 | at | #6 Wichita State | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/18/2008 | * | #26 East Carolina | 3 | at | #7 Rice | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Baylor | 1 | at | #8 Texas A&M | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #23 Mississippi | 2 | at | #9 South Carolina | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #10 Missouri | 9 | at | Oklahoma | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Auburn |
| at | #11 Vanderbilt |
| Suspended | | Recap | Suspended to 4/19, inclement weather (5-3 Auburn, bottom 7) |
| 4/18/2008 | * | St. Mary's | 2 | at | #12 San Diego | 9 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Kansas | 6 | at | #13 Nebraska | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #14 Oklahoma State | 2 | at | #15 Texas | 1 | FINAL | Box Score | Recap | 11 innings |
| 4/18/2008 | * | Wake Forest | 2 | at | #16 Virginia | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #29 Florida | 7 | at | #17 Kentucky | 11 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #18 Cal State Fullerton | 15 | at | Pacific | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | North Carolina-Asheville | 3 | at | #19 Coastal Carolina | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Washington | 5 | at | #20 California | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #21 Georgia | 6 | at | Louisiana State | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Washington State | 6 | at | #22 Arizona | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/18/2008 | * | #24 Long Beach State | 16 | at | Cal State Northridge | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #25 Stanford | 4 | at | UCLA | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Michigan State | 3 | at | #27 Michigan | 8 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #28 Georgia Tech | 5 | at | Maryland | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #30 North Carolina-Wilmington | 13 | at | Delaware | 14 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/18/2008 | * | Albany | 4 | at | Binghamton | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Maine | 6 | at | Maryland-Baltimore County | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/18/2008 | * | Maine | 8 | at | Maryland-Baltimore County | 21 | FINAL | Box Score | Recap | 7 innings |
| 4/18/2008 | * | Stony Brook | 10 | at | Vermont | 4 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/18/2008 | * | Dayton | 12 | at | George Washington | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Duquesne | 4 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Fordham | 7 | at | LaSalle | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | North Carolina-Charlotte | 18 | at | Massachusetts | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Rhode Island | 8 | at | Richmond | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | St. Joseph's | 1 | at | Xavier | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | St. Louis | 11 | at | St. Bonaventure | 1 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/18/2008 | * | #1 Miami, Florida | 11 | at | #2 Florida State | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Boston College | 3 | at | #4 North Carolina | 12 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Wake Forest | 2 | at | #16 Virginia | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #28 Georgia Tech | 5 | at | Maryland | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Clemson | 7 | at | Duke | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | North Carolina State | 8 | at | Virginia Tech | 2 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/18/2008 | * | Belmont | 4 | at | East Tennessee State | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Campbell | 8 | at | Gardner-Webb | 13 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Florida Gulf Coast | 5 | at | Jacksonville | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Florida Gulf Coast | 4 | at | Jacksonville | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Lipscomb | 9 | at | South Carolina-Upstate | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Mercer | 8 | at | Kennesaw State | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Stetson | 2 | at | North Florida | 5 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/18/2008 | * | Michigan State | 3 | at | #27 Michigan | 8 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Illinois |
| at | Minnesota |
| Postponed | | Recap | PPD to 4/20, rain |
| 4/18/2008 | * | Indiana | 3 | at | Penn State | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Northwestern |
| at | Iowa |
| Postponed | | Recap | PPD to 4/20, rain |
| 4/18/2008 | * | Purdue | 7 | at | Ohio State | 4 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/18/2008 | * | Baylor | 1 | at | #8 Texas A&M | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #10 Missouri | 9 | at | Oklahoma | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Kansas | 6 | at | #13 Nebraska | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #14 Oklahoma State | 2 | at | #15 Texas | 1 | FINAL | Box Score | Recap | 11 innings |
| 4/18/2008 | * | Kansas State | 12 | at | Texas Tech | 4 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/18/2008 | * | Georgetown | 1 | at | Cincinnati | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Notre Dame | 8 | at | West Virginia | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Seton Hall | 9 | at | Connecticut | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | South Florida | 7 | at | Rutgers | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | St. John's | 3 | at | Pittsburgh | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Villanova | 5 | at | Louisville | 12 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/18/2008 | * | North Carolina-Asheville | 3 | at | #19 Coastal Carolina | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Radford | 1 | at | High Point | 8 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | VMI | 0 | at | Liberty | 8 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Winthrop | 4 | at | Charleston Southern | 9 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/18/2008 | * | UC Riverside | 2 | at | #5 UC Irvine | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #18 Cal State Fullerton | 15 | at | Pacific | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #24 Long Beach State | 16 | at | Cal State Northridge | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Cal Poly | 2 | at | UC Davis | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Southern California | 4 | at | UC Santa Barbara | 6 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/18/2008 | * | #30 North Carolina-Wilmington | 13 | at | Delaware | 14 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | James Madison | 2 | at | George Mason | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Old Dominion | 11 | at | Hofstra | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Virginia Commonwealth | 4 | at | William and Mary | 8 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/18/2008 | * | #26 East Carolina | 3 | at | #7 Rice | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Houston | 9 | at | Alabama-Birmingham | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Southern Mississippi | 3 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | UCF | 10 | at | Marshall | 12 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Dallas Baptist | 4 | at | Memphis | 3 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/18/2008 |
| Air Force | 6 | at | Northern Colorado | 13 | FINAL | Box Score | Recap | Northern Colorado Triangular, Greeley, CO |
| 4/18/2008 |
| Chicago State |
| at | Illinois State |
| Postponed | | Recap | PPD to 4/20, rain |
| 4/18/2008 |
| Dallas Baptist | 4 | at | Memphis | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Florida Atlantic | 7 | at | New York Tech | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Hawaii-Hilo | 2 | at | Cal State Sacramento | 12 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/18/2008 |
| Utah Valley State | 7 | vs | Air Force | 8 | FINAL | Box Score | Recap | 10 innings (Northern Colorado Triangular, Greeley, CO) |
| Horizon League |
| 4/18/2008 | * | Illinois-Chicago | 14 | at | Valparaiso | 12 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Illinois-Chicago | 14 | at | Valparaiso | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Tiffin | 4 | vs | Cleveland State | 3 | FINAL | Box Score | Recap | Lorain, OH |
| Mid American Conference |
| 4/18/2008 | * | Ball State | 3 | at | Central Michigan | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Kent State | 11 | at | Bowling Green State | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Miami, Ohio | 8 | at | Buffalo | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/18/2008 | * | Northern Illinois | 9 | at | Toledo | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Ohio | 6 | at | Akron | 7 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Western Michigan | 4 | at | Eastern Michigan | 5 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/18/2008 | * | Southern Illinois | 0 | at | #6 Wichita State | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/18/2008 | * | Creighton |
| at | Northern Iowa |
| Postponed | | Recap | PPD to 4/19, rain |
| 4/18/2008 | * | Indiana State |
| at | Evansville |
| Suspended | | Recap | Suspended to 4/19, rain (2-0 EU, top 4) |
| 4/18/2008 | * | Missouri State |
| at | Bradley |
| Postponed | | Recap | PPD to 4/19, inclement weather |
| 4/18/2008 |
| Chicago State |
| at | Illinois State |
| Postponed | | Recap | PPD to 4/20, rain |
| Mountain West Conference |
| 4/18/2008 | * | San Diego State | 17 | at | Nevada-Las Vegas | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Texas Christian | 13 | at | Brigham Young | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Utah | 4 | at | New Mexico | 5 | FINAL | Box Score | Recap | 12 innings |
| 4/18/2008 |
| Air Force | 6 | at | Northern Colorado | 13 | FINAL | Box Score | Recap | Northern Colorado Triangular, Greeley, CO |
| 4/18/2008 |
| Utah Valley State | 7 | vs | Air Force | 8 | FINAL | Box Score | Recap | 10 innings (Northern Colorado Triangular, Greeley, CO) |
| Northeast Conference |
| 4/18/2008 | * | Long Island | 6 | at | Central Connecticut State | 7 | FINAL | Box Score | Recap | Bristol, CT |
| 4/18/2008 | * | Mount St. Mary's | 23 | at | Sacred Heart | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Quinnipiac | 5 | at | Monmouth | 18 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Wagner | 3 | at | Fairleigh Dickinson | 16 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/18/2008 | * | Oregon State | 6 | at | #3 Arizona State | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Washington | 5 | at | #20 California | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Washington State | 6 | at | #22 Arizona | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/18/2008 | * | #25 Stanford | 4 | at | UCLA | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Southern California | 4 | at | UC Santa Barbara | 6 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/18/2008 | * | #23 Mississippi | 2 | at | #9 South Carolina | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Auburn |
| at | #11 Vanderbilt |
| Suspended | | Recap | Suspended to 4/19, inclement weather (5-3 Auburn, bottom 7) |
| 4/18/2008 | * | #29 Florida | 7 | at | #17 Kentucky | 11 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | #21 Georgia | 6 | at | Louisiana State | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Mississippi State |
| at | Alabama |
| Postponed | | Recap | PPD to 4/19, rain |
| 4/18/2008 | * | Tennessee | 4 | at | Arkansas | 5 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/18/2008 | * | Elon | 15 | at | College of Charleston | 14 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Georgia Southern | 10 | at | Davidson | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | North Carolina-Greensboro | 3 | at | The Citadel | 1 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Western Carolina | 2 | at | Appalachian State | 6 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Wofford | 1 | at | Furman | 17 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/18/2008 | * | Central Arkansas | 7 | at | Texas State | 13 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Lamar | 6 | at | Texas A&M-Corpus Christi | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | McNeese State | 1 | at | Sam Houston State | 2 | FINAL | Box Score | Recap | 10 innings |
| 4/18/2008 | * | Northwestern State |
| at | Nicholls State |
| Postponed | | Recap | PPD to 4/19, field conditions |
| 4/18/2008 | * | Southeastern Louisiana | 1 | at | Texas-Arlington | 2 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Stephen F. Austin | 1 | at | Texas-San Antonio | 9 | FINAL | Box Score | Recap | |
| Summit League |
| 4/18/2008 | * | Centenary | 5 | at | Oakland | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | North Dakota State | 2 | at | IUPU-Fort Wayne | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | South Dakota State | 7 | at | Southern Utah | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | South Dakota State | 2 | at | Southern Utah | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/18/2008 | * | Western Illinois | 2 | at | Oral Roberts | 19 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/18/2008 | * | Arkansas State | 1 | at | Western Kentucky | 8 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Arkansas-Little Rock | 0 | at | Troy | 4 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Florida International | 14 | at | New Orleans | 19 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Louisiana-Lafayette | 9 | at | South Alabama | 3 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Middle Tennessee State | 4 | at | Louisiana-Monroe | 5 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Florida Atlantic | 7 | at | New York Tech | 10 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/18/2008 | * | St. Mary's | 2 | at | #12 San Diego | 9 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Pepperdine | 5 | at | Loyola Marymount | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/18/2008 | * | Portland | 5 | at | Gonzaga | 11 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | San Francisco | 0 | at | Santa Clara | 8 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/18/2008 | * | Fresno State | 13 | at | New Mexico State | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 | * | Louisiana Tech | 1 | at | San Jose State | 11 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/18/2008 | * | Nevada | 4 | at | Hawaii | 10 | FINAL | Box Score | Recap | |
| 4/18/2008 |
| Hawaii-Hilo | 2 | at | Cal State Sacramento | 12 | FINAL | Box Score | Recap | 7 innings, run rule |