| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/22/2008 |
| #3 North Carolina | 17 | at | North Carolina-Charlotte | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Sam Houston State | 2 | at | #4 Rice | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #5 Arizona State | 9 | at | #18 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas State | 11 | at | #6 Texas A&M | 14 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #7 South Carolina | 5 | at | Furman | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Kansas | 4 | at | #8 Wichita State | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Eastern Illinois | 6 | vs | #9 Missouri | 8 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/22/2008 |
| #10 Vanderbilt | 9 | at | Austin Peay State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #11 UC Irvine | 4 | at | Kansas State | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #23 Long Beach State | 2 | at | #12 San Diego | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Creighton | 3 | at | #13 Nebraska | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Mid-America Christian | 4 | at | #14 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| College of Charleston | 6 | at | #15 Coastal Carolina | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Kennesaw State | 2 | at | #16 Georgia | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #17 Kentucky | 5 | at | Louisville | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cal Poly | 8 | at | #19 California | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Mexico | 1 | at | #20 Arizona | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Georgetown | 1 | at | #21 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #25 Texas | 8 | at | Baylor | 2 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Murray State | 5 | at | #26 Mississippi | 15 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #27 North Carolina-Wilmington | 1 | at | East Carolina | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #30 Oral Roberts | 6 | at | Missouri State | 9 | FINAL | Box Score | Recap | |
| America East Conference |
| 4/22/2008 |
| Albany | 7 | at | LeMoyne | 11 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| George Washington | 11 | at | Maryland-Baltimore County | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Marist | 8 | at | Hartford | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Stony Brook | 18 | at | Hofstra | 16 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Thomas | 4 | at | Maine | 13 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Vermont | 9 | at | Dartmouth | 10 | FINAL | Box Score | Recap | 12 innings |
| Atlantic 10 Conference |
| 4/22/2008 |
| #3 North Carolina | 17 | at | North Carolina-Charlotte | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Central Connecticut State | 9 | at | Massachusetts | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/22/2008 |
| George Washington | 11 | at | Maryland-Baltimore County | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Iona | 4 | at | Fordham | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| LaSalle | 3 | at | Penn State | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Missouri-St. Louis | 6 | at | St. Louis | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Rhode Island | 9 | at | Sacred Heart | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| St. Bonaventure | 2 | at | Buffalo | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| St. Bonaventure | 11 | at | Buffalo | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Villanova | 13 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Virginia Commonwealth |
| at | Richmond |
| Canceled | | Recap | CCD, field conditions |
| 4/22/2008 |
| West Virginia | 9 | at | Duquesne | 1 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Xavier | 4 | at | Ball State | 14 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/22/2008 |
| #3 North Carolina | 17 | at | North Carolina-Charlotte | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Georgetown | 1 | at | #21 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Clemson | 6 | at | Western Carolina | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Duke | 10 | at | North Carolina-Greensboro | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Georgia Tech | 16 | at | Mercer | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Harvard | 4 | at | Boston College | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Old Dominion | 5 | at | Maryland | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Radford | 4 | vs | Virginia Tech | 5 | FINAL | Box Score | Recap | Pulaski, VA |
| 4/22/2008 |
| Wake Forest | 10 | at | Elon | 19 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/22/2008 |
| Kennesaw State | 2 | at | #16 Georgia | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Campbell |
| at | Longwood |
| Postponed | | Recap | PPD, rain |
| 4/22/2008 |
| Gardner-Webb | 5 | at | North Carolina-Asheville | 6 | FINAL | Box Score | Recap | 12 innings |
| 4/22/2008 |
| Georgia Tech | 16 | at | Mercer | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Lipscomb | 4 | at | Alabama | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| North Florida | 4 | at | Georgia Southern | 17 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| South Carolina-Upstate | 7 | at | Presbyterian | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Stetson | 6 | at | Bethune-Cookman | 2 | FINAL | Box Score | Recap | 11 innings |
| 4/22/2008 |
| Tennessee Tech | 13 | at | Belmont | 3 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/22/2008 |
| Illinois State | 4 | at | Illinois | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| LaSalle | 3 | at | Penn State | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Robert Morris | 8 | at | Northwestern | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wisconsin-Milwaukee | 13 | at | Iowa | 5 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 4/22/2008 |
| Texas State | 11 | at | #6 Texas A&M | 14 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Kansas | 4 | at | #8 Wichita State | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Eastern Illinois | 6 | vs | #9 Missouri | 8 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/22/2008 |
| #11 UC Irvine | 4 | at | Kansas State | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Creighton | 3 | at | #13 Nebraska | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Mid-America Christian | 4 | at | #14 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #25 Texas | 8 | at | Baylor | 2 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Mexico State | 2 | at | Texas Tech | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas Christian | 6 | at | Oklahoma | 11 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/22/2008 |
| #17 Kentucky | 5 | at | Louisville | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Georgetown | 1 | at | #21 Virginia | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Chicago State | 2 | at | Notre Dame | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cincinnati | 6 | at | Ohio | 18 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Connecticut | 12 | at | Fairfield | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Princeton | 2 | at | St. John's | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Seton Hall | 6 | at | New York Tech | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| South Florida | 19 | at | Florida Atlantic | 11 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Villanova | 13 | at | Temple | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wagner | 3 | at | Rutgers | 7 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/22/2008 |
| West Virginia | 9 | at | Duquesne | 1 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/22/2008 |
| College of Charleston | 6 | at | #15 Coastal Carolina | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Coppin State | 8 | at | VMI | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Gardner-Webb | 5 | at | North Carolina-Asheville | 6 | FINAL | Box Score | Recap | 12 innings |
| 4/22/2008 |
| Liberty | 7 | at | James Madison | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Radford | 4 | vs | Virginia Tech | 5 | FINAL | Box Score | Recap | Pulaski, VA |
| Big West Conference |
| 4/22/2008 |
| #5 Arizona State | 9 | at | #18 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #11 UC Irvine | 4 | at | Kansas State | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #23 Long Beach State | 2 | at | #12 San Diego | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cal Poly | 8 | at | #19 California | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Loyola Marymount | 7 | at | UC Riverside | 1 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| UC Santa Barbara | 0 | at | Cal State Northridge | 7 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/22/2008 |
| #27 North Carolina-Wilmington | 1 | at | East Carolina | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Delaware | 13 | at | Delaware State | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| George Mason |
| at | Mount St. Mary's |
| Canceled | | Recap | CCD, impending weather |
| 4/22/2008 |
| Liberty | 7 | at | James Madison | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Old Dominion | 5 | at | Maryland | 6 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Stony Brook | 18 | at | Hofstra | 16 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Virginia Commonwealth |
| at | Richmond |
| Canceled | | Recap | CCD, field conditions |
| Conference USA |
| 4/22/2008 |
| Sam Houston State | 2 | at | #4 Rice | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #27 North Carolina-Wilmington | 1 | at | East Carolina | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Jacksonville State |
| at | Alabama-Birmingham |
| Suspended | | Recap | Suspended to 5/7, technical problem (7-3 UAB, bottom 5) |
| 4/22/2008 |
| Louisiana State | 8 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Marshall | 1 | at | Kent State | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| McNeese State | 4 | at | Houston | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Memphis | 7 | at | Middle Tennessee State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Mississippi State | 7 | at | Southern Mississippi | 11 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/22/2008 |
| Albany | 7 | at | LeMoyne | 11 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Campbell |
| at | Longwood |
| Postponed | | Recap | PPD, rain |
| 4/22/2008 |
| Chicago State | 2 | at | Notre Dame | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Hawaii-Hilo | 4 | at | San Jose State | 13 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Northern Colorado | 2 | at | Arkansas | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Seton Hall | 6 | at | New York Tech | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| South Carolina-Upstate | 7 | at | Presbyterian | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| St. Peter's | 8 | at | New Jersey Tech | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Stephen F. Austin | 3 | at | Dallas Baptist | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas A&M-Corpus Christi | 10 | at | Texas-Pan American | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas A&M-Corpus Christi | 8 | at | Texas-Pan American | 2 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/22/2008 |
| Canisius | 8 | at | Cleveland State | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Canisius | 3 | at | Cleveland State | 5 | FINAL | Box Score | Recap | 500th career win for CSU's Kevin Kocks (7 innings) |
| 4/22/2008 |
| Illinois-Chicago | 3 | vs | Northern Illinois | 4 | FINAL | Box Score | Recap | Geneva, IL |
| 4/22/2008 |
| Valparaiso | 2 | at | Central Michigan | 13 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wisconsin-Milwaukee | 13 | at | Iowa | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wright State | 12 | at | Toledo | 9 | FINAL | Box Score | Recap | 11 innings |
| Ivy League |
| 4/22/2008 |
| Harvard | 4 | at | Boston College | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Princeton | 2 | at | St. John's | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Siena | 2 | at | Cornell | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Siena | 2 | at | Cornell | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Vermont | 9 | at | Dartmouth | 10 | FINAL | Box Score | Recap | 12 innings |
| Metro Atlantic Athletic Conference |
| 4/22/2008 |
| Canisius | 8 | at | Cleveland State | 9 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Canisius | 3 | at | Cleveland State | 5 | FINAL | Box Score | Recap | 500th career win for CSU's Kevin Kocks (7 innings) |
| 4/22/2008 |
| Connecticut | 12 | at | Fairfield | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Iona | 4 | at | Fordham | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Marist | 8 | at | Hartford | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Monmouth | 8 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Siena | 2 | at | Cornell | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Siena | 2 | at | Cornell | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| St. Peter's | 8 | at | New Jersey Tech | 6 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/22/2008 |
| Albion | 1 | at | Bowling Green State | 21 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cincinnati | 6 | at | Ohio | 18 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Illinois-Chicago | 3 | vs | Northern Illinois | 4 | FINAL | Box Score | Recap | Geneva, IL |
| 4/22/2008 |
| Indiana State | 8 | at | Miami, Ohio | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Marshall | 1 | at | Kent State | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| St. Bonaventure | 2 | at | Buffalo | 3 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| St. Bonaventure | 11 | at | Buffalo | 1 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Valparaiso | 2 | at | Central Michigan | 13 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wright State | 12 | at | Toledo | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/22/2008 |
| Xavier | 4 | at | Ball State | 14 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/22/2008 |
| Coppin State | 8 | at | VMI | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Delaware | 13 | at | Delaware State | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Florida A&M | 6 | at | Alabama State | 3 | FINAL | Box Score | | |
| 4/22/2008 |
| Maryland-Eastern Shore | 1 | at | Navy | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| North Carolina A&T | 9 | at | Wofford | 1 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Stetson | 6 | at | Bethune-Cookman | 2 | FINAL | Box Score | Recap | 11 innings |
| Missouri Valley Conference |
| 4/22/2008 |
| Kansas | 4 | at | #8 Wichita State | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Creighton | 3 | at | #13 Nebraska | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #30 Oral Roberts | 6 | at | Missouri State | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Bradley |
| at | Western Illinois |
| Canceled | | Recap | CCD, rain |
| 4/22/2008 |
| Clarke | 0 | at | Northern Iowa | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/22/2008 |
| Illinois State | 4 | at | Illinois | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Indiana State | 8 | at | Miami, Ohio | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Tennessee-Martin | 13 | at | Evansville | 12 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/22/2008 |
| New Mexico | 1 | at | #20 Arizona | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Nevada-Las Vegas | 7 | at | UCLA | 8 | FINAL | Box Score | Recap | 11 innings |
| 4/22/2008 |
| San Diego State | 6 | at | Southern California | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Southern Utah | 6 | at | Utah | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas Christian | 6 | at | Oklahoma | 11 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/22/2008 |
| Central Connecticut State | 9 | at | Massachusetts | 7 | FINAL | Box Score | Recap | 12 innings |
| 4/22/2008 |
| George Mason |
| at | Mount St. Mary's |
| Canceled | | Recap | CCD, impending weather |
| 4/22/2008 |
| Monmouth | 8 | at | Rider | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Rhode Island | 9 | at | Sacred Heart | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wagner | 3 | at | Rutgers | 7 | FINAL | Box Score | Recap | makeup of 4/1 game |
| Ohio Valley Conference |
| 4/22/2008 |
| Eastern Illinois | 6 | vs | #9 Missouri | 8 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/22/2008 |
| #10 Vanderbilt | 9 | at | Austin Peay State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Murray State | 5 | at | #26 Mississippi | 15 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Berea | 9 | at | Eastern Kentucky | 17 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Jacksonville State |
| at | Alabama-Birmingham |
| Suspended | | Recap | Suspended to 5/7, technical problem (7-3 UAB, bottom 5) |
| 4/22/2008 |
| Samford | 12 | at | Auburn | 11 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Southeast Missouri State | 12 | at | Arkansas State | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Tennessee Tech | 13 | at | Belmont | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Tennessee-Martin | 13 | at | Evansville | 12 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/22/2008 |
| #5 Arizona State | 9 | at | #18 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cal Poly | 8 | at | #19 California | 10 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Mexico | 1 | at | #20 Arizona | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Gonzaga | 8 | at | Washington State | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Nevada-Las Vegas | 7 | at | UCLA | 8 | FINAL | Box Score | Recap | 11 innings |
| 4/22/2008 |
| San Diego State | 6 | at | Southern California | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Washington |
| at | Portland |
| Postponed | | Recap | PPD, impending weather |
| Patriot League |
| 4/22/2008 |
| Maryland-Eastern Shore | 1 | at | Navy | 5 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/22/2008 |
| #7 South Carolina | 5 | at | Furman | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #10 Vanderbilt | 9 | at | Austin Peay State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Kennesaw State | 2 | at | #16 Georgia | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| #17 Kentucky | 5 | at | Louisville | 6 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Murray State | 5 | at | #26 Mississippi | 15 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Appalachian State | 4 | at | Tennessee | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Lipscomb | 4 | at | Alabama | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Louisiana State | 8 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Mississippi State | 7 | at | Southern Mississippi | 11 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Northern Colorado | 2 | at | Arkansas | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Samford | 12 | at | Auburn | 11 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/22/2008 |
| #7 South Carolina | 5 | at | Furman | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| College of Charleston | 6 | at | #15 Coastal Carolina | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Appalachian State | 4 | at | Tennessee | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Clemson | 6 | at | Western Carolina | 0 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Duke | 10 | at | North Carolina-Greensboro | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| North Carolina A&T | 9 | at | Wofford | 1 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| North Florida | 4 | at | Georgia Southern | 17 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Wake Forest | 10 | at | Elon | 19 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/22/2008 |
| Sam Houston State | 2 | at | #4 Rice | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas State | 11 | at | #6 Texas A&M | 14 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Alcorn State | 4 | at | Southeastern Louisiana | 14 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/22/2008 |
| Louisiana-Lafayette | 0 | at | Lamar | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| McNeese State | 4 | at | Houston | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Stephen F. Austin | 3 | at | Dallas Baptist | 7 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas A&M-Corpus Christi | 10 | at | Texas-Pan American | 5 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Texas A&M-Corpus Christi | 8 | at | Texas-Pan American | 2 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/22/2008 |
| Alcorn State | 4 | at | Southeastern Louisiana | 14 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/22/2008 |
| Delta State |
| at | Mississippi Valley State |
| Canceled | | | CCD, rain |
| 4/22/2008 |
| Florida A&M | 6 | at | Alabama State | 3 | FINAL | Box Score | | |
| 4/22/2008 |
| Jackson State | 0 | at | South Alabama | 18 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/22/2008 |
| Jarvis Christian | 11 | at | Grambling State | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Orleans | 6 | at | Southern | 3 | FINAL | Box Score | Recap | 5 innings, inclement weather |
| Summit League |
| 4/22/2008 |
| #30 Oral Roberts | 6 | at | Missouri State | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Arkansas-Little Rock | 3 | at | Centenary | 2 | FINAL | Box Score | Recap | 6 innings, lightning |
| 4/22/2008 |
| Bradley |
| at | Western Illinois |
| Canceled | | Recap | CCD, rain |
| 4/22/2008 |
| Dakota Wesleyan | 2 | at | South Dakota State | 12 | FINAL | Box Score | Recap | 7 innings |
| 4/22/2008 |
| Southern Utah | 6 | at | Utah | 9 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/22/2008 |
| Arkansas-Little Rock | 3 | at | Centenary | 2 | FINAL | Box Score | Recap | 6 innings, lightning |
| 4/22/2008 |
| Jackson State | 0 | at | South Alabama | 18 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/22/2008 |
| Louisiana-Lafayette | 0 | at | Lamar | 3 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Memphis | 7 | at | Middle Tennessee State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Orleans | 6 | at | Southern | 3 | FINAL | Box Score | Recap | 5 innings, inclement weather |
| 4/22/2008 |
| South Florida | 19 | at | Florida Atlantic | 11 | FINAL | Box Score | Recap | 10 innings |
| 4/22/2008 |
| Southeast Missouri State | 12 | at | Arkansas State | 3 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/22/2008 |
| #23 Long Beach State | 2 | at | #12 San Diego | 4 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Cal State Sacramento | 8 | at | San Francisco | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Gonzaga | 8 | at | Washington State | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Loyola Marymount | 7 | at | UC Riverside | 1 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Santa Clara | 10 | at | Fresno State | 8 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Washington |
| at | Portland |
| Postponed | | Recap | PPD, impending weather |
| Western Athletic Conference |
| 4/22/2008 |
| Cal State Sacramento | 8 | at | San Francisco | 9 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Hawaii-Hilo | 4 | at | San Jose State | 13 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| New Mexico State | 2 | at | Texas Tech | 12 | FINAL | Box Score | Recap | |
| 4/22/2008 |
| Santa Clara | 10 | at | Fresno State | 8 | FINAL | Box Score | Recap | |