| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/23/2008 |
| Florida International | 6 | at | #1 Miami, Florida | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| High Point | 5 | at | #3 North Carolina | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #5 Arizona State | 10 | at | #18 Cal State Fullerton | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Wofford | 1 | at | #7 South Carolina | 10 | FINAL | Box Score | Recap | 3 HR for SC's Justin Smoak |
| 4/23/2008 |
| #8 Wichita State | 3 | at | #14 Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Southern Illinois | 2 | vs | #9 Missouri | 1 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/23/2008 |
| #10 Vanderbilt | 10 | at | Belmont | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #11 UC Irvine | 7 | at | Kansas State | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| #13 Nebraska | 16 | at | Creighton | 7 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/23/2008 |
| Wake Forest | 8 | at | #15 Coastal Carolina | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #17 Kentucky | 2 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| New Mexico | 4 | at | #20 Arizona | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| William and Mary | 6 | at | #21 Virginia | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| St. Mary's | 4 | at | #22 Stanford | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Texas-San Antonio | 7 | at | #25 Texas | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #26 Mississippi | 9 | at | Arkansas State | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| North Carolina Central | 8 | at | #27 North Carolina-Wilmington | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #28 North Carolina State | 7 | at | North Carolina-Greensboro | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Portland |
| at | #29 Oregon State |
| Postponed | | Recap | PPD, inclement weather |
| America East Conference |
| 4/23/2008 |
| Binghamton | 12 | at | LeMoyne | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Quinnipiac | 11 | at | Vermont | 12 | FINAL | Box Score | Recap | 12 innings |
| 4/23/2008 |
| Yale | 11 | at | Hartford | 6 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/23/2008 |
| Bucknell | 9 | at | St. Bonaventure | 6 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Connecticut | 4 | at | Rhode Island | 9 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Dayton | 6 | at | Butler | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Dayton | 19 | at | Butler | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| James Madison | 8 | at | George Washington | 5 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| Kent State | 9 | at | Duquesne | 18 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Miami, Ohio | 8 | at | Xavier | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Missouri State | 9 | at | St. Louis | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| New York Tech | 12 | at | Fordham | 13 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| South Carolina-Upstate | 7 | at | North Carolina-Charlotte | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| St. Joseph's | 3 | at | Villanova | 12 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 4/23/2008 |
| Florida International | 6 | at | #1 Miami, Florida | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| High Point | 5 | at | #3 North Carolina | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Wake Forest | 8 | at | #15 Coastal Carolina | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| William and Mary | 6 | at | #21 Virginia | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #28 North Carolina State | 7 | at | North Carolina-Greensboro | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Duke | 8 | at | Davidson | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Maryland | 3 | at | Towson | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Presbyterian | 7 | vs | Clemson | 12 | FINAL | Box Score | Recap | Greenville, SC |
| Atlantic Sun Conference |
| 4/23/2008 |
| #10 Vanderbilt | 10 | at | Belmont | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Appalachian State | 9 | at | Gardner-Webb | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| East Carolina | 9 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| East Tennessee State | 11 | at | Tennessee | 9 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Florida A&M |
| at | North Florida |
| Canceled | | | CCD |
| 4/23/2008 |
| Georgia Southern | 6 | at | Kennesaw State | 4 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| South Carolina-Upstate | 7 | at | North Carolina-Charlotte | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Stetson | 1 | at | South Florida | 2 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Western Carolina | 8 | at | Mercer | 7 | FINAL | Box Score | Recap | 10 innings |
| Big 10 Conference |
| 4/23/2008 |
| Akron | 7 | at | Ohio State | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Akron | 7 | at | Ohio State | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Ball State | 1 | at | Purdue | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Indiana State | 2 | at | Indiana | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Iowa | 5 | at | Northern Iowa | 2 | FINAL | Box Score | Recap | 400th career win for Iowa's Jack Dahm |
| 4/23/2008 |
| Minnesota | 4 | vs | South Dakota State | 5 | FINAL | Box Score | Recap | 10 innings (Sioux Falls, SD) |
| 4/23/2008 |
| Toledo | 6 | at | Michigan State | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Western Illinois | 2 | at | Illinois | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Youngstown State | 4 | at | Penn State | 5 | FINAL | Box Score | Recap | 13 innings |
| Big 12 Conference |
| 4/23/2008 |
| #8 Wichita State | 3 | at | #14 Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Southern Illinois | 2 | vs | #9 Missouri | 1 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/23/2008 |
| #11 UC Irvine | 7 | at | Kansas State | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| #13 Nebraska | 16 | at | Creighton | 7 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/23/2008 |
| Texas-San Antonio | 7 | at | #25 Texas | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Baylor | 25 | at | Texas State | 13 | FINAL | Box Score | Recap | 8 innings |
| 4/23/2008 |
| Southern Nazarene | 8 | at | Oklahoma | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Texas Tech | 16 | vs | New Mexico State | 10 | FINAL | Box Score | Recap | TT's Chris Richburg hits for cycle (Roswell, NM) |
| Big East Conference |
| 4/23/2008 |
| Connecticut | 4 | at | Rhode Island | 9 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Fairleigh Dickinson | 0 | at | Seton Hall | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Lafayette | 9 | at | Rutgers | 10 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| Morehead State | 3 | at | Cincinnati | 18 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Notre Dame | 5 | at | IUPU-Fort Wayne | 0 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| St. Joseph's | 3 | at | Villanova | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Stetson | 1 | at | South Florida | 2 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/23/2008 |
| High Point | 5 | at | #3 North Carolina | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Wake Forest | 8 | at | #15 Coastal Carolina | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Coppin State | 4 | at | VMI | 13 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Elon | 9 | at | Winthrop | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Liberty | 11 | at | Old Dominion | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| North Carolina A&T | 5 | at | North Carolina-Asheville | 6 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Radford | 6 | at | George Mason | 7 | FINAL | Box Score | Recap | 10 innings |
| Big West Conference |
| 4/23/2008 |
| #5 Arizona State | 10 | at | #18 Cal State Fullerton | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| #11 UC Irvine | 7 | at | Kansas State | 9 | FINAL | Box Score | Recap | 11 innings |
| Colonial Athletic Association |
| 4/23/2008 |
| William and Mary | 6 | at | #21 Virginia | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| North Carolina Central | 8 | at | #27 North Carolina-Wilmington | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| James Madison | 8 | at | George Washington | 5 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| Liberty | 11 | at | Old Dominion | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Maryland | 3 | at | Towson | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Radford | 6 | at | George Mason | 7 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Savannah State | 7 | at | Georgia State | 8 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/23/2008 |
| Alabama-Birmingham | 16 | at | Samford | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| East Carolina | 9 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Marshall | 17 | at | Ohio | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Memphis | 17 | at | Middle Tennessee State | 11 | FINAL | Box Score | Recap | 14 innings |
| 4/23/2008 |
| Mississippi State | 7 | at | Southern Mississippi | 12 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/23/2008 |
| North Carolina Central | 8 | at | #27 North Carolina-Wilmington | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Binghamton | 12 | at | LeMoyne | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Hawaii-Hilo | 2 | at | San Jose State | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| New Jersey Tech | 2 | at | Siena | 11 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| New York Tech | 12 | at | Fordham | 13 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Norfolk State | 2 | at | Longwood | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Norfolk State |
| at | Longwood |
| Canceled | | | CCD |
| 4/23/2008 |
| Northern Colorado | 1 | at | Arkansas | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Presbyterian | 7 | vs | Clemson | 12 | FINAL | Box Score | Recap | Greenville, SC |
| 4/23/2008 |
| Savannah State | 7 | at | Georgia State | 8 | FINAL | Box Score | Recap | |
| Horizon League |
| 4/23/2008 |
| Central Michigan | 7 | at | Illinois-Chicago | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Dayton | 6 | at | Butler | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Dayton | 19 | at | Butler | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Judson | 0 | at | Valparaiso | 13 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Mt. Vernon Nazarene | 8 | at | Cleveland State | 2 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Youngstown State | 4 | at | Penn State | 5 | FINAL | Box Score | Recap | 13 innings |
| Ivy League |
| 4/23/2008 |
| Columbia | 0 | at | Manhattan | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Columbia | 2 | at | Manhattan | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Holy Cross | 3 | at | Brown | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Holy Cross | 14 | at | Brown | 12 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Lehigh | 3 | at | Pennsylvania | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Lehigh | 2 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Yale | 11 | at | Hartford | 6 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 4/23/2008 |
| Buffalo | 6 | at | Niagara | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Columbia | 0 | at | Manhattan | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Columbia | 2 | at | Manhattan | 4 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Iona | 4 | at | Wagner | 11 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Long Island | 8 | at | Rider | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Monmouth | 12 | at | St. Peter's | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| New Jersey Tech | 2 | at | Siena | 11 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/23/2008 |
| Akron | 7 | at | Ohio State | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Akron | 7 | at | Ohio State | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Ball State | 1 | at | Purdue | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Buffalo | 6 | at | Niagara | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Central Michigan | 7 | at | Illinois-Chicago | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Illinois State | 14 | at | Northern Illinois | 10 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/23/2008 |
| Kent State | 9 | at | Duquesne | 18 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Marshall | 17 | at | Ohio | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Miami, Ohio | 8 | at | Xavier | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Oakland | 6 | at | Bowling Green State | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Olivet | 1 | at | Eastern Michigan | 15 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Toledo | 6 | at | Michigan State | 10 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 4/23/2008 |
| Coppin State | 4 | at | VMI | 13 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Florida A&M |
| at | North Florida |
| Canceled | | | CCD |
| 4/23/2008 |
| Norfolk State | 2 | at | Longwood | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Norfolk State |
| at | Longwood |
| Canceled | | | CCD |
| 4/23/2008 |
| North Carolina A&T | 5 | at | North Carolina-Asheville | 6 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/23/2008 |
| #8 Wichita State | 3 | at | #14 Oklahoma State | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Southern Illinois | 2 | vs | #9 Missouri | 1 | FINAL | Box Score | Recap | O'Fallon, MO |
| 4/23/2008 |
| #13 Nebraska | 16 | at | Creighton | 7 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/23/2008 |
| Austin Peay State | 5 | at | Evansville | 2 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Eastern Illinois | 4 | at | Bradley | 11 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Illinois State | 14 | at | Northern Illinois | 10 | FINAL | Box Score | Recap | makeup of 4/1 game |
| 4/23/2008 |
| Indiana State | 2 | at | Indiana | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Iowa | 5 | at | Northern Iowa | 2 | FINAL | Box Score | Recap | 400th career win for Iowa's Jack Dahm |
| 4/23/2008 |
| Missouri State | 9 | at | St. Louis | 4 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/23/2008 |
| New Mexico | 4 | at | #20 Arizona | 10 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/23/2008 |
| Fairleigh Dickinson | 0 | at | Seton Hall | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Iona | 4 | at | Wagner | 11 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Long Island | 8 | at | Rider | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Monmouth | 12 | at | St. Peter's | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Quinnipiac | 11 | at | Vermont | 12 | FINAL | Box Score | Recap | 12 innings |
| Ohio Valley Conference |
| 4/23/2008 |
| Alabama-Birmingham | 16 | at | Samford | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Austin Peay State | 5 | at | Evansville | 2 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Eastern Illinois | 4 | at | Bradley | 11 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Kentucky State | 0 | at | Eastern Kentucky | 14 | FINAL | Box Score | Recap | 6 innings |
| 4/23/2008 |
| Kentucky State | 2 | at | Eastern Kentucky | 15 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Morehead State | 3 | at | Cincinnati | 18 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Tennessee Tech | 15 | at | Alabama A&M | 2 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/23/2008 |
| Troy | 10 | at | Jacksonville State | 3 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/23/2008 |
| #5 Arizona State | 10 | at | #18 Cal State Fullerton | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| New Mexico | 4 | at | #20 Arizona | 10 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| St. Mary's | 4 | at | #22 Stanford | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Portland |
| at | #29 Oregon State |
| Postponed | | Recap | PPD, inclement weather |
| Patriot League |
| 4/23/2008 |
| Bucknell | 9 | at | St. Bonaventure | 6 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Holy Cross | 3 | at | Brown | 5 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Holy Cross | 14 | at | Brown | 12 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Lafayette | 9 | at | Rutgers | 10 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| Lehigh | 3 | at | Pennsylvania | 0 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Lehigh | 2 | at | Pennsylvania | 6 | FINAL | Box Score | Recap | 7 innings |
| Southeastern Conference |
| 4/23/2008 |
| Wofford | 1 | at | #7 South Carolina | 10 | FINAL | Box Score | Recap | 3 HR for SC's Justin Smoak |
| 4/23/2008 |
| #10 Vanderbilt | 10 | at | Belmont | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #17 Kentucky | 2 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #26 Mississippi | 9 | at | Arkansas State | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Alabama | 9 | at | South Alabama | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| East Tennessee State | 11 | at | Tennessee | 9 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| McNeese State | 0 | at | Louisiana State | 6 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Mississippi State | 7 | at | Southern Mississippi | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Northern Colorado | 1 | at | Arkansas | 7 | FINAL | Box Score | Recap | |
| Southern Conference |
| 4/23/2008 |
| Wofford | 1 | at | #7 South Carolina | 10 | FINAL | Box Score | Recap | 3 HR for SC's Justin Smoak |
| 4/23/2008 |
| #28 North Carolina State | 7 | at | North Carolina-Greensboro | 8 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Appalachian State | 9 | at | Gardner-Webb | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Duke | 8 | at | Davidson | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Elon | 9 | at | Winthrop | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Georgia Southern | 6 | at | Kennesaw State | 4 | FINAL | Box Score | Recap | 11 innings |
| 4/23/2008 |
| Western Carolina | 8 | at | Mercer | 7 | FINAL | Box Score | Recap | 10 innings |
| Southland Conference |
| 4/23/2008 |
| Texas-San Antonio | 7 | at | #25 Texas | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Arkansas-Pine Bluff | 0 | at | Central Arkansas | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Baylor | 25 | at | Texas State | 13 | FINAL | Box Score | Recap | 8 innings |
| 4/23/2008 |
| Centenary | 7 | at | Sam Houston State | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Louisiana-Lafayette | 4 | at | Southeastern Louisiana | 14 | FINAL | Box Score | Recap | makeup of 4/2 game |
| 4/23/2008 |
| McNeese State | 0 | at | Louisiana State | 6 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Nicholls State | 8 | at | Loyola (LA) | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Northwestern State | 10 | at | Louisiana Tech | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Texas Wesleyan |
| at | Texas-Arlington |
| Postponed | | Recap | PPD, inclement weather |
| Southwestern Athletic Conference |
| 4/23/2008 |
| Arkansas-Pine Bluff | 0 | at | Central Arkansas | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Grambling State | 5 | at | Louisiana-Monroe | 17 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Tennessee Tech | 15 | at | Alabama A&M | 2 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/23/2008 |
| Texas Southern | 6 | at | Houston Baptist | 2 | FINAL | Box Score | Recap | 7 innings |
| 4/23/2008 |
| Texas Southern | 1 | at | Houston Baptist | 25 | FINAL | Box Score | Recap | 5 innings, run rule |
| Summit League |
| 4/23/2008 |
| Centenary | 7 | at | Sam Houston State | 8 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Minnesota | 4 | vs | South Dakota State | 5 | FINAL | Box Score | Recap | 10 innings (Sioux Falls, SD) |
| 4/23/2008 |
| Notre Dame | 5 | at | IUPU-Fort Wayne | 0 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Oakland | 6 | at | Bowling Green State | 14 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Western Illinois | 2 | at | Illinois | 10 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/23/2008 |
| Florida International | 6 | at | #1 Miami, Florida | 3 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #17 Kentucky | 2 | at | Western Kentucky | 1 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| #26 Mississippi | 9 | at | Arkansas State | 4 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Alabama | 9 | at | South Alabama | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Grambling State | 5 | at | Louisiana-Monroe | 17 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Louisiana-Lafayette | 4 | at | Southeastern Louisiana | 14 | FINAL | Box Score | Recap | makeup of 4/2 game |
| 4/23/2008 |
| Memphis | 17 | at | Middle Tennessee State | 11 | FINAL | Box Score | Recap | 14 innings |
| 4/23/2008 |
| Troy | 10 | at | Jacksonville State | 3 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 4/23/2008 |
| St. Mary's | 4 | at | #22 Stanford | 7 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Portland |
| at | #29 Oregon State |
| Postponed | | Recap | PPD, inclement weather |
| 4/23/2008 |
| Lewis-Clark State |
| at | Gonzaga |
| Postponed | | Recap | PPD to 5/12, inclement weather |
| 4/23/2008 |
| San Francisco | 4 | at | Fresno State | 5 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 4/23/2008 |
| Hawaii-Hilo | 2 | at | San Jose State | 3 | FINAL | Box Score | Recap | 10 innings |
| 4/23/2008 |
| Northwestern State | 10 | at | Louisiana Tech | 12 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| San Francisco | 4 | at | Fresno State | 5 | FINAL | Box Score | Recap | |
| 4/23/2008 |
| Texas Tech | 16 | vs | New Mexico State | 10 | FINAL | Box Score | Recap | TT's Chris Richburg hits for cycle (Roswell, NM) |
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