| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 4/25/2008 | * | #21 Virginia | 0 | at | #1 Miami, Florida | 1 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #2 Florida State | 4 | at | #3 North Carolina | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #4 Rice | 2 | at | UCF | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #19 California | 7 | at | #5 Arizona State | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #9 Missouri | 8 | at | #6 Texas A&M | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #7 South Carolina | 3 | at | Louisiana State | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #8 Wichita State |
| at | Indiana State |
| Suspended | | Recap | Suspended to 4/26, inclement weather (8-7 WSU, top 9) |
| 4/25/2008 | * | #17 Kentucky | 2 | at | #10 Vanderbilt | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| #11 UC Irvine | 5 | at | New Mexico | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Loyola Marymount | 4 | at | #12 San Diego | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #13 Nebraska |
| at | Baylor |
| Postponed | | Recap | PPD to 4/26, inclement weather |
| 4/25/2008 | * | Kansas | 1 | at | #14 Oklahoma State | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #15 Coastal Carolina | 5 | at | VMI | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #16 Georgia | 7 | at | Florida | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | UC Davis | 3 | at | #18 Cal State Fullerton | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #20 Arizona | 7 | at | #29 Oregon State | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Southern California | 0 | at | #22 Stanford | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Pacific | 3 | at | #23 Long Beach State | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #24 Michigan | 14 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #25 Texas | 6 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Arkansas | 4 | at | #26 Mississippi | 12 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| New York Tech | 6 | at | #27 North Carolina-Wilmington | 13 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Boston College | 1 | at | #28 North Carolina State | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #30 Oral Roberts | 7 | at | Southern Utah | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #30 Oral Roberts | 15 | at | Southern Utah | 8 | FINAL | Box Score | Recap | 7 innings |
| America East Conference |
| 4/25/2008 | * | Maryland-Baltimore County | 13 | at | Hartford | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Stony Brook | 8 | at | Maine | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Vermont | 4 | at | Albany | 10 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 4/25/2008 | * | Duquesne | 4 | at | North Carolina-Charlotte | 5 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2008 | * | Fordham | 9 | at | Temple | 1 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | George Washington |
| at | St. Louis |
| Postponed | | Recap | PPD to 4/26, inclement weather |
| 4/25/2008 | * | Massachusetts | 4 | at | St. Joseph's | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Rhode Island | 4 | at | LaSalle | 7 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Richmond | 5 | at | Dayton | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | St. Bonaventure | 5 | at | Xavier | 6 | FINAL | Box Score | Recap | 12 innings |
| Atlantic Coast Conference |
| 4/25/2008 | * | #21 Virginia | 0 | at | #1 Miami, Florida | 1 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #2 Florida State | 4 | at | #3 North Carolina | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Boston College | 1 | at | #28 North Carolina State | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Maryland | 12 | at | Duke | 8 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Virginia Tech | 5 | at | Clemson | 13 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Wake Forest | 1 | at | Georgia Tech | 12 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 4/25/2008 | * | East Tennessee State | 1 | at | Lipscomb | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Gardner-Webb | 8 | at | Mercer | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Kennesaw State | 14 | at | Campbell | 3 | FINAL | Box Score | Recap | 8 innings, run rule |
| 4/25/2008 | * | Kennesaw State | 5 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | South Carolina-Upstate | 3 | at | Belmont | 6 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 4/25/2008 | * | #24 Michigan | 14 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Iowa | 16 | at | Michigan State | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Minnesota | 2 | at | Purdue | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Ohio State | 11 | at | Northwestern | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Penn State |
| at | Illinois |
| Suspended | | Recap | Suspended to 4/26, rain (16-11 Illinois, bottom 8) |
| Big 12 Conference |
| 4/25/2008 | * | #9 Missouri | 8 | at | #6 Texas A&M | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #13 Nebraska |
| at | Baylor |
| Postponed | | Recap | PPD to 4/26, inclement weather |
| 4/25/2008 | * | Kansas | 1 | at | #14 Oklahoma State | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #25 Texas | 6 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Oklahoma | 12 | at | Texas Tech | 7 | FINAL | Box Score | Recap | |
| Big East Conference |
| 4/25/2008 | * | Cincinnati | 11 | at | Louisville | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Connecticut | 1 | at | West Virginia | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Georgetown | 2 | at | Pittsburgh | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Rutgers | 7 | at | Seton Hall | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | St. John's | 10 | at | Notre Dame | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Villanova | 5 | at | South Florida | 8 | FINAL | Box Score | Recap | |
| Big South Conference |
| 4/25/2008 | * | #15 Coastal Carolina | 5 | at | VMI | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Liberty | 5 | at | Winthrop | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | North Carolina-Asheville | 0 | at | Radford | 4 | FINAL | Box Score | Recap | |
| Big West Conference |
| 4/25/2008 |
| #11 UC Irvine | 5 | at | New Mexico | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | UC Davis | 3 | at | #18 Cal State Fullerton | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Pacific | 3 | at | #23 Long Beach State | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Cal State Northridge | 0 | at | UC Riverside | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | UC Santa Barbara | 2 | at | Cal Poly | 3 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 4/25/2008 |
| New York Tech | 6 | at | #27 North Carolina-Wilmington | 13 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | George Mason | 6 | at | Delaware | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Hofstra | 1 | at | Georgia State | 7 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Northeastern | 0 | at | Old Dominion | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Virginia Commonwealth | 6 | at | James Madison | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | William and Mary | 12 | at | Towson | 15 | FINAL | Box Score | Recap | |
| Conference USA |
| 4/25/2008 | * | #4 Rice | 2 | at | UCF | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Houston | 9 | at | Southern Mississippi | 12 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Marshall | 3 | at | Alabama-Birmingham | 15 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Tulane | 17 | at | Memphis | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Presbyterian | 1 | at | East Carolina | 6 | FINAL | Box Score | Recap | |
| Division I Independents |
| 4/25/2008 |
| New York Tech | 6 | at | #27 North Carolina-Wilmington | 13 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Chicago State | 1 | at | Bradley | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Dallas Baptist | 22 | at | Northern Colorado | 15 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Hawaii-Hilo | 0 | at | Santa Clara | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| 4/25/2008 |
| Presbyterian | 1 | at | East Carolina | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Texas-Pan American | 18 | at | Arkansas-Pine Bluff | 0 | FINAL | Box Score | | 6 innings, rain |
| Horizon League |
| 4/25/2008 | * | Butler | 12 | at | Valparaiso | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Wisconsin-Milwaukee | 13 | at | Wright State | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Youngstown State | 8 | at | Cleveland State | 19 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Trinity International |
| at | Illinois-Chicago |
| Suspended | | Recap | Suspended to 4/26, inclement weather (1-0, bottom 1) |
| Ivy League |
| 4/25/2008 | * | Princeton | 5 | at | Cornell | 6 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Princeton | 19 | at | Cornell | 1 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 4/25/2008 | * | Akron | 4 | at | Buffalo | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Ball State | 11 | at | Western Michigan | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Bowling Green State | 8 | at | Miami, Ohio | 9 | FINAL | Box Score | Recap | 11 innings |
| 4/25/2008 | * | Central Michigan | 1 | at | Toledo | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Eastern Michigan | 4 | at | Northern Illinois | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Ohio | 7 | at | Kent State | 2 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 4/25/2008 | * | #8 Wichita State |
| at | Indiana State |
| Suspended | | Recap | Suspended to 4/26, inclement weather (8-7 WSU, top 9) |
| 4/25/2008 | * | Evansville | 4 | at | Creighton | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Illinois State | 1 | at | Missouri State | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Southern Illinois | 13 | at | Northern Iowa | 14 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Chicago State | 1 | at | Bradley | 5 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 4/25/2008 |
| #11 UC Irvine | 5 | at | New Mexico | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Brigham Young | 22 | at | Air Force | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Nevada-Las Vegas | 2 | at | Utah | 10 | FINAL | Box Score | Recap | Ogden, UT |
| 4/25/2008 | * | Texas Christian | 1 | at | San Diego State | 4 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 4/25/2008 | * | Long Island | 4 | at | Quinnipiac | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Monmouth | 6 | at | Central Connecticut State | 2 | FINAL | Box Score | Recap | Bristol, CT |
| 4/25/2008 | * | Sacred Heart | 11 | at | Fairleigh Dickinson | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Wagner | 1 | at | Mount St. Mary's | 5 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 4/25/2008 | * | #19 California | 7 | at | #5 Arizona State | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #20 Arizona | 7 | at | #29 Oregon State | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Southern California | 0 | at | #22 Stanford | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | UCLA | 2 | at | Washington | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| San Jose State | 3 | at | Washington State | 8 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 4/25/2008 | * | #7 South Carolina | 3 | at | Louisiana State | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #17 Kentucky | 2 | at | #10 Vanderbilt | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #16 Georgia | 7 | at | Florida | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Arkansas | 4 | at | #26 Mississippi | 12 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Auburn | 5 | at | Alabama | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Tennessee | 3 | at | Mississippi State | 4 | FINAL | Box Score | Recap | 12 innings |
| Southern Conference |
| 4/25/2008 | * | Davidson | 5 | at | Appalachian State | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Elon | 9 | at | North Carolina-Greensboro | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Furman | 4 | at | Western Carolina | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Georgia Southern | 15 | at | Wofford | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | The Citadel | 2 | at | College of Charleston | 12 | FINAL | Box Score | Recap | |
| Southland Conference |
| 4/25/2008 | * | Central Arkansas | 1 | at | Southeastern Louisiana | 7 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Lamar | 5 | at | Texas State | 4 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2008 | * | Sam Houston State | 10 | at | Texas-San Antonio | 12 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Stephen F. Austin | 8 | at | Nicholls State | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Texas A&M-Corpus Christi | 3 | at | McNeese State | 2 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Texas-Arlington | 2 | at | Northwestern State | 8 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 4/25/2008 | * | Alabama State | 7 | at | Jackson State | 10 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Mississippi Valley State | 4 | at | Alcorn State | 5 | FINAL | Box Score | | 7 innings |
| 4/25/2008 | * | Mississippi Valley State | 8 | at | Alcorn State | 3 | FINAL | Box Score | | 7 innings |
| 4/25/2008 | * | Texas Southern | 3 | at | Prairie View A&M | 6 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2008 | * | Texas Southern | 1 | at | Prairie View A&M | 7 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2008 |
| Texas-Pan American | 18 | at | Arkansas-Pine Bluff | 0 | FINAL | Box Score | | 6 innings, rain |
| Summit League |
| 4/25/2008 | * | #30 Oral Roberts | 7 | at | Southern Utah | 0 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | #30 Oral Roberts | 15 | at | Southern Utah | 8 | FINAL | Box Score | Recap | 7 innings |
| 4/25/2008 | * | Centenary | 5 | at | IUPU-Fort Wayne | 16 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 4/25/2008 | * | Louisiana-Monroe | 6 | at | Florida International | 9 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | New Orleans |
| at | Arkansas State |
| Suspended | | Recap | Suspended to 4/26, lightning (5-1 UNO, bottom 8) |
| 4/25/2008 | * | South Alabama | 10 | at | Middle Tennessee State | 5 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Troy | 3 | at | Louisiana-Lafayette | 7 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Western Kentucky | 6 | at | Florida Atlantic | 12 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| Houston Baptist | 5 | at | Arkansas-Little Rock | 3 | FINAL | Box Score | Recap | 13 innings |
| West Coast Conference |
| 4/25/2008 | * | Loyola Marymount | 4 | at | #12 San Diego | 11 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Gonzaga | 11 | at | St. Mary's | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Portland | 9 | at | San Francisco | 10 | FINAL | Box Score | Recap | 10 innings |
| 4/25/2008 |
| Hawaii-Hilo | 0 | at | Santa Clara | 10 | FINAL | Box Score | Recap | 7 innings, run rule |
| Western Athletic Conference |
| 4/25/2008 | * | Fresno State | 9 | at | Nevada | 3 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | Hawaii | 13 | at | Louisiana Tech | 7 | FINAL | Box Score | Recap | |
| 4/25/2008 | * | New Mexico State | 7 | at | Cal State Sacramento | 4 | FINAL | Box Score | Recap | |
| 4/25/2008 |
| San Jose State | 3 | at | Washington State | 8 | FINAL | Box Score | Recap | |