| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/6/2008 |
| North Florida | 2 | at | #2 North Carolina | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #4 Arizona State | 6 | at | Kansas State | 7 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Texas State | 1 | at | #5 Rice | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #6 Texas A&M | 13 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #9 San Diego | 5 | at | UCLA | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #10 UC Irvine | 10 | at | UC Riverside | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #11 Vanderbilt | 8 | vs | Memphis | 0 | FINAL | Box Score | Recap | Jackson, TN |
| 5/6/2008 |
| Central Arkansas | 10 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Pepperdine | 1 | at | #15 Cal State Fullerton | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Creighton | 4 | at | #16 Missouri | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #18 Stanford | 9 | at | San Francisco | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| UC Davis | 4 | at | #20 California | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #21 North Carolina State | 6 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Wright State | 3 | at | #22 Kentucky | 21 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #23 Michigan | 15 | at | Ball State | 8 | FINAL | Box Score | Recap | moved from 4/7 and Ann Arbor, impending weather |
| 5/6/2008 |
| Fresno State | 1 | at | #25 Long Beach State | 2 | FINAL | Box Score | Recap | |
| America East Conference |
| 5/6/2008 |
| Central Connecticut State |
| at | Hartford |
| Canceled | | Recap | CCD, scheduling conflict (makeup of 3/12 game) |
| 5/6/2008 |
| Delaware | 7 | at | Maryland-Baltimore County | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| LeMoyne | 15 | at | Albany | 8 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 5/6/2008 |
| Dayton | 3 | at | Toledo | 2 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Northeastern | 6 | at | Massachusetts | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Richmond | 7 | at | Norfolk State | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/6/2008 |
| Rider | 1 | at | St. Joseph's | 8 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Washington and Jefferson | 7 | at | Duquesne | 7 | FINAL | Box Score | | 11 innings, darkness |
| Atlantic Coast Conference |
| 5/6/2008 |
| North Florida | 2 | at | #2 North Carolina | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #21 North Carolina State | 6 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Davidson | 1 | at | Duke | 2 | FINAL | Box Score | Recap | 10 innings |
| 5/6/2008 |
| Maryland-Eastern Shore | 0 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/6/2008 |
| North Florida | 2 | at | #2 North Carolina | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #21 North Carolina State | 6 | at | Campbell | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Florida International | 1 | at | Florida Gulf Coast | 12 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| James Madison | 8 | at | East Tennessee State | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Samford | 2 | at | Lipscomb | 4 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 5/6/2008 |
| #23 Michigan | 15 | at | Ball State | 8 | FINAL | Box Score | Recap | moved from 4/7 and Ann Arbor, impending weather |
| 5/6/2008 |
| Elmhurst | 4 | at | Northwestern | 15 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Louisville | 13 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Valparaiso | 5 | at | Iowa | 13 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 5/6/2008 |
| #4 Arizona State | 6 | at | Kansas State | 7 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #6 Texas A&M | 13 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Creighton | 4 | at | #16 Missouri | 5 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/6/2008 |
| Coppin State | 3 | at | Pittsburgh | 17 | FINAL | Box Score | Recap | 7 innings (Panther Classic, Pittsburgh, PA) |
| 5/6/2008 |
| Iona | 2 | at | St. John's | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Iona | 2 | at | St. John's | 15 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Louisville | 13 | at | Indiana | 6 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Mount St. Joseph | 3 | at | Cincinnati | 20 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| New York Tech | 1 | at | Seton Hall | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| UCF | 9 | at | South Florida | 5 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/6/2008 |
| Charleston Southern | 6 | at | Furman | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| High Point | 3 | at | North Carolina-Greensboro | 4 | FINAL | Box Score | Recap | 10 innings |
| Big West Conference |
| 5/6/2008 |
| #10 UC Irvine | 10 | at | UC Riverside | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Pepperdine | 1 | at | #15 Cal State Fullerton | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| UC Davis | 4 | at | #20 California | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Fresno State | 1 | at | #25 Long Beach State | 2 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Cal Poly | 3 | at | Southern California | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Cal State Northridge | 3 | at | Nevada-Las Vegas | 10 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/6/2008 |
| Delaware | 7 | at | Maryland-Baltimore County | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Hofstra | 5 | at | Manhattan | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| James Madison | 8 | at | East Tennessee State | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Northeastern | 6 | at | Massachusetts | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Presbyterian | 4 | at | Georgia State | 10 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Presbyterian | 1 | at | Georgia State | 7 | FINAL | Box Score | Recap | 7 innings |
| Conference USA |
| 5/6/2008 |
| Texas State | 1 | at | #5 Rice | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #11 Vanderbilt | 8 | vs | Memphis | 0 | FINAL | Box Score | Recap | Jackson, TN |
| 5/6/2008 |
| Alabama-Birmingham | 9 | at | Jacksonville State | 11 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Lamar |
| at | Houston |
| Canceled | | Recap | CCD, inclement weather (makeup of 3/18 game) |
| 5/6/2008 |
| New Orleans | 9 | at | Tulane | 8 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| UCF | 9 | at | South Florida | 5 | FINAL | Box Score | Recap | |
| Division I Independents |
| 5/6/2008 |
| Chicago State | 13 | at | Wisconsin-Milwaukee | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Chicago State | 3 | at | Wisconsin-Milwaukee | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| LeMoyne | 15 | at | Albany | 8 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| New York Tech | 1 | at | Seton Hall | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Presbyterian | 4 | at | Georgia State | 10 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Presbyterian | 1 | at | Georgia State | 7 | FINAL | Box Score | Recap | 7 innings |
| Horizon League |
| 5/6/2008 |
| Wright State | 3 | at | #22 Kentucky | 21 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Chicago State | 13 | at | Wisconsin-Milwaukee | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Chicago State | 3 | at | Wisconsin-Milwaukee | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Valparaiso | 5 | at | Iowa | 13 | FINAL | Box Score | Recap | |
| Ivy League |
| 5/6/2008 | IVY-02 | Dartmouth | 16 | vs | Columbia | 15 | FINAL | Box Score | Recap | Ivy League Championship, Game 2 (Hanover, NH) |
| 5/6/2008 | IVY-01 | Columbia | 11 | vs | Dartmouth | 7 | FINAL | Box Score | Recap | Ivy League Championship, Game 1 (Hanover, NH) |
| Metro Atlantic Athletic Conference |
| 5/6/2008 |
| Hofstra | 5 | at | Manhattan | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Iona | 2 | at | St. John's | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Iona | 2 | at | St. John's | 15 | FINAL | Box Score | Recap | 7 innings |
| 5/6/2008 |
| Rider | 1 | at | St. Joseph's | 8 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 5/6/2008 |
| #23 Michigan | 15 | at | Ball State | 8 | FINAL | Box Score | Recap | moved from 4/7 and Ann Arbor, impending weather |
| 5/6/2008 |
| Coppin State | 2 | vs | Central Michigan | 13 | FINAL | Box Score | Recap | 7 innings, run rule (Panther Classic, Pittsburgh, PA) |
| 5/6/2008 |
| Dayton | 3 | at | Toledo | 2 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Eastern Michigan | 5 | at | Bowling Green State | 15 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Otterbein | 9 | at | Ohio | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Western Michigan | 5 | at | Oakland | 19 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/6/2008 |
| Bethune-Cookman | 2 | at | Florida Atlantic | 12 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Coppin State | 2 | vs | Central Michigan | 13 | FINAL | Box Score | Recap | 7 innings, run rule (Panther Classic, Pittsburgh, PA) |
| 5/6/2008 |
| Coppin State | 3 | at | Pittsburgh | 17 | FINAL | Box Score | Recap | 7 innings (Panther Classic, Pittsburgh, PA) |
| 5/6/2008 |
| Florida Atlantic | 8 | vs | Bethune-Cookman | 10 | FINAL | Box Score | Recap | Resumption of 2/26 game (Boca Raton, FL) |
| 5/6/2008 |
| Maryland-Eastern Shore | 0 | at | Maryland | 6 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Richmond | 7 | at | Norfolk State | 6 | FINAL | Box Score | Recap | 10 innings |
| Missouri Valley Conference |
| 5/6/2008 |
| Central Arkansas | 10 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Creighton | 4 | at | #16 Missouri | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Eastern Illinois | 6 | at | Indiana State | 11 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 5/6/2008 |
| Cal State Northridge | 3 | at | Nevada-Las Vegas | 10 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Southern Utah | 3 | at | Utah | 22 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Washington State | 13 | at | Brigham Young | 7 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/6/2008 |
| Central Connecticut State |
| at | Hartford |
| Canceled | | Recap | CCD, scheduling conflict (makeup of 3/12 game) |
| Ohio Valley Conference |
| 5/6/2008 |
| Alabama-Birmingham | 9 | at | Jacksonville State | 11 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Eastern Illinois | 6 | at | Indiana State | 11 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Samford | 2 | at | Lipscomb | 4 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 5/6/2008 |
| #4 Arizona State | 6 | at | Kansas State | 7 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #9 San Diego | 5 | at | UCLA | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #18 Stanford | 9 | at | San Francisco | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| UC Davis | 4 | at | #20 California | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Cal Poly | 3 | at | Southern California | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Washington | 9 | at | Portland | 2 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Washington State | 13 | at | Brigham Young | 7 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 5/6/2008 |
| #11 Vanderbilt | 8 | vs | Memphis | 0 | FINAL | Box Score | Recap | Jackson, TN |
| 5/6/2008 |
| Wright State | 3 | at | #22 Kentucky | 21 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Mississippi State | 5 | at | Middle Tennessee State | 20 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/6/2008 |
| Charleston Southern | 6 | at | Furman | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Davidson | 1 | at | Duke | 2 | FINAL | Box Score | Recap | 10 innings |
| 5/6/2008 |
| High Point | 3 | at | North Carolina-Greensboro | 4 | FINAL | Box Score | Recap | 10 innings |
| Southland Conference |
| 5/6/2008 |
| Texas State | 1 | at | #5 Rice | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #6 Texas A&M | 13 | at | Sam Houston State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Central Arkansas | 10 | at | #13 Wichita State | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Lamar |
| at | Houston |
| Canceled | | Recap | CCD, inclement weather (makeup of 3/18 game) |
| 5/6/2008 |
| Southeastern Louisiana | 12 | at | Alcorn State | 10 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 5/6/2008 |
| Southeastern Louisiana | 12 | at | Alcorn State | 10 | FINAL | Box Score | Recap | |
| Summit League |
| 5/6/2008 |
| Augustana |
| at | South Dakota State |
| Canceled | | Recap | CCD, rain |
| 5/6/2008 |
| Southern Utah | 3 | at | Utah | 22 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Western Michigan | 5 | at | Oakland | 19 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 5/6/2008 |
| Bethune-Cookman | 2 | at | Florida Atlantic | 12 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Florida Atlantic | 8 | vs | Bethune-Cookman | 10 | FINAL | Box Score | Recap | Resumption of 2/26 game (Boca Raton, FL) |
| 5/6/2008 |
| Florida International | 1 | at | Florida Gulf Coast | 12 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Louisiana Tech | 3 | at | Louisiana-Lafayette | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Mississippi State | 5 | at | Middle Tennessee State | 20 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| New Orleans | 9 | at | Tulane | 8 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 5/6/2008 |
| #9 San Diego | 5 | at | UCLA | 3 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Pepperdine | 1 | at | #15 Cal State Fullerton | 9 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| #18 Stanford | 9 | at | San Francisco | 13 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| San Jose State | 7 | at | St. Mary's | 5 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Washington | 9 | at | Portland | 2 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 5/6/2008 |
| Fresno State | 1 | at | #25 Long Beach State | 2 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| Louisiana Tech | 3 | at | Louisiana-Lafayette | 4 | FINAL | Box Score | Recap | |
| 5/6/2008 |
| San Jose State | 7 | at | St. Mary's | 5 | FINAL | Box Score | Recap | |