| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/7/2008 |
| North Florida | 5 | at | #2 North Carolina | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Jacksonville | 7 | at | #3 Florida State | 6 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #4 Arizona State | 6 | at | #13 Wichita State | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #8 Oklahoma State | 2 | at | #5 Rice | 4 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Tennessee Tech | 2 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #12 South Carolina | 10 | at | Wofford | 5 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Georgia Tech | 11 | at | #14 Georgia | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Missouri State |
| at | #16 Missouri |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| #18 St. Mary's | 6 | at | San Francisco | 5 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #21 North Carolina State | 2 | at | #29 North Carolina-Wilmington | 3 | FINAL | Box Score | Recap | 11 innings |
| America East Conference |
| 5/7/2008 |
| Stony Brook | 6 | at | Seton Hall | 3 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 5/7/2008 |
| Akron | 9 | at | Duquesne | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| LaSalle | 7 | at | Maryland-Eastern Shore | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Ohio | 12 | at | Dayton | 3 | FINAL | Box Score | Recap | 5 innings, rain |
| 5/7/2008 |
| Temple | 4 | at | Delaware | 22 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/7/2008 |
| North Florida | 5 | at | #2 North Carolina | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Jacksonville | 7 | at | #3 Florida State | 6 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Georgia Tech | 11 | at | #14 Georgia | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #21 North Carolina State | 2 | at | #29 North Carolina-Wilmington | 3 | FINAL | Box Score | Recap | 11 innings |
| 5/7/2008 |
| Furman | 5 | at | Clemson | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Liberty | 7 | at | Virginia Tech | 6 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Towson | 4 | at | Maryland | 7 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/7/2008 |
| North Florida | 5 | at | #2 North Carolina | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Jacksonville | 7 | at | #3 Florida State | 6 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Belmont | 5 | at | Tennessee | 3 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| East Tennessee State |
| at | Appalachian State |
| Canceled | | Recap | CCD, scheduling conflict |
| 5/7/2008 |
| Florida Gulf Coast | 7 | at | Florida Atlantic | 5 | FINAL | Box Score | Recap | 11 innings |
| 5/7/2008 |
| Presbyterian | 2 | at | South Carolina-Upstate | 9 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 5/7/2008 |
| Cincinnati |
| at | Indiana |
| Canceled | | Recap | CCD, scheduling conflict |
| 5/7/2008 |
| Marshall | 1 | at | Ohio State | 8 | FINAL | Box Score | Recap | 5 innings, inclement weather |
| 5/7/2008 |
| Minnesota | 4 | at | North Dakota State | 9 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Purdue |
| at | Indiana State |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Western Michigan | 6 | at | Michigan State | 8 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 5/7/2008 |
| #8 Oklahoma State | 2 | at | #5 Rice | 4 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Missouri State |
| at | #16 Missouri |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Oral Roberts |
| at | Kansas |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Texas Tech | 7 | at | Dallas Baptist | 16 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/7/2008 |
| Butler | 1 | at | Louisville | 8 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Central Michigan | 10 | at | Pittsburgh | 8 | FINAL | Box Score | Recap | Panther Classic, Pittsburgh, PA |
| 5/7/2008 |
| Cincinnati |
| at | Indiana |
| Canceled | | Recap | CCD, scheduling conflict |
| 5/7/2008 |
| Coppin State | 5 | at | Pittsburgh | 25 | FINAL | Box Score | Recap | 7 innings, run rule (Panther Classic, Pittsburgh, PA) |
| 5/7/2008 |
| Fairleigh Dickinson | 2 | at | Rutgers | 10 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Stony Brook | 6 | at | Seton Hall | 3 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/7/2008 |
| Charleston Southern | 4 | at | College of Charleston | 13 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Liberty | 7 | at | Virginia Tech | 6 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Longwood | 9 | at | High Point | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Radford | 3 | at | Old Dominion | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| The Citadel | 14 | at | Winthrop | 7 | FINAL | Box Score | Recap | |
| Big West Conference |
| 5/7/2008 |
| Cal State Northridge | 4 | at | Nevada-Las Vegas | 2 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Santa Clara | 7 | at | Pacific | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| UC Santa Barbara | 4 | at | Pepperdine | 5 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/7/2008 |
| #21 North Carolina State | 2 | at | #29 North Carolina-Wilmington | 3 | FINAL | Box Score | Recap | 11 innings |
| 5/7/2008 |
| Hofstra |
| at | Long Island |
| Canceled | | Recap | CCD, scheduling conflict |
| 5/7/2008 |
| Radford | 3 | at | Old Dominion | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Temple | 4 | at | Delaware | 22 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Towson | 4 | at | Maryland | 7 | FINAL | Box Score | Recap | |
| Conference USA |
| 5/7/2008 |
| #8 Oklahoma State | 2 | at | #5 Rice | 4 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Jacksonville State | 3 | at | Alabama-Birmingham | 17 | FINAL | Box Score | Recap | Resumption of 4/22 game |
| 5/7/2008 |
| Jacksonville State | 17 | at | Alabama-Birmingham | 8 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Marshall | 1 | at | Ohio State | 8 | FINAL | Box Score | Recap | 5 innings, inclement weather |
| 5/7/2008 |
| Tulane | 10 | at | Southern | 3 | FINAL | Box Score | Recap | |
| Division I Independents |
| 5/7/2008 |
| Army | 3 | at | New York Tech | 4 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Eastern Illinois |
| at | Chicago State |
| Canceled | | Recap | CCD, rain |
| 5/7/2008 |
| Longwood | 9 | at | High Point | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Presbyterian | 2 | at | South Carolina-Upstate | 9 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Texas Tech | 7 | at | Dallas Baptist | 16 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/7/2008 |
| Butler | 1 | at | Louisville | 8 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Wisconsin-Milwaukee | 6 | at | Northern Iowa | 9 | FINAL | Box Score | Recap | |
| Ivy League |
| 5/7/2008 | IVY-03 | Columbia | 7 | vs | Dartmouth | 5 | FINAL | Box Score | Recap | Ivy League Championship, Game 3 (Hanover, NH) |
| Metro Atlantic Athletic Conference |
| 5/7/2008 |
| Lafayette | 7 | at | Rider | 8 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 5/7/2008 |
| Akron | 9 | at | Duquesne | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Bowling Green State |
| at | Eastern Michigan |
| Canceled | | Recap | CCD, rain |
| 5/7/2008 |
| Central Michigan | 10 | at | Pittsburgh | 8 | FINAL | Box Score | Recap | Panther Classic, Pittsburgh, PA |
| 5/7/2008 |
| Ohio | 12 | at | Dayton | 3 | FINAL | Box Score | Recap | 5 innings, rain |
| 5/7/2008 |
| Toledo | 19 | at | Oakland | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/7/2008 |
| Toledo |
| at | Oakland |
| Canceled | | Recap | CCD, rain |
| 5/7/2008 |
| Western Michigan | 6 | at | Michigan State | 8 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/7/2008 |
| Bethune-Cookman | 10 | at | Florida | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Coppin State | 5 | at | Pittsburgh | 25 | FINAL | Box Score | Recap | 7 innings, run rule (Panther Classic, Pittsburgh, PA) |
| 5/7/2008 |
| LaSalle | 7 | at | Maryland-Eastern Shore | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| North Carolina A&T | 5 | at | North Carolina-Greensboro | 3 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 5/7/2008 |
| #4 Arizona State | 6 | at | #13 Wichita State | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Missouri State |
| at | #16 Missouri |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Evansville | 4 | at | Austin Peay State | 10 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Purdue |
| at | Indiana State |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Wisconsin-Milwaukee | 6 | at | Northern Iowa | 9 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 5/7/2008 |
| Cal State Northridge | 4 | at | Nevada-Las Vegas | 2 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Washington State | 12 | at | Brigham Young | 5 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/7/2008 |
| Fairleigh Dickinson | 2 | at | Rutgers | 10 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Hofstra |
| at | Long Island |
| Canceled | | Recap | CCD, scheduling conflict |
| Ohio Valley Conference |
| 5/7/2008 |
| Tennessee Tech | 2 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Eastern Illinois |
| at | Chicago State |
| Canceled | | Recap | CCD, rain |
| 5/7/2008 |
| Evansville | 4 | at | Austin Peay State | 10 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Jacksonville State | 3 | at | Alabama-Birmingham | 17 | FINAL | Box Score | Recap | Resumption of 4/22 game |
| 5/7/2008 |
| Jacksonville State | 17 | at | Alabama-Birmingham | 8 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 5/7/2008 |
| #4 Arizona State | 6 | at | #13 Wichita State | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Oregon State | 4 | vs | Portland | 1 | FINAL | Box Score | Recap | Resumption of 4/15 game (Corvallis, OR) |
| 5/7/2008 |
| Washington State | 12 | at | Brigham Young | 5 | FINAL | Box Score | Recap | |
| Patriot League |
| 5/7/2008 |
| Army | 3 | at | New York Tech | 4 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Lafayette | 7 | at | Rider | 8 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 5/7/2008 |
| Tennessee Tech | 2 | at | #11 Vanderbilt | 7 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| #12 South Carolina | 10 | at | Wofford | 5 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Georgia Tech | 11 | at | #14 Georgia | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Belmont | 5 | at | Tennessee | 3 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Bethune-Cookman | 10 | at | Florida | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Mississippi State | 4 | at | Middle Tennessee State | 3 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/7/2008 |
| #12 South Carolina | 10 | at | Wofford | 5 | FINAL | Box Score | Recap | |
| 5/7/2008 | * | Elon | 19 | at | Davidson | 9 | FINAL | Box Score | Recap | |
| 5/7/2008 | * | Elon | 7 | at | Davidson | 1 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Charleston Southern | 4 | at | College of Charleston | 13 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| East Tennessee State |
| at | Appalachian State |
| Canceled | | Recap | CCD, scheduling conflict |
| 5/7/2008 |
| Furman | 5 | at | Clemson | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| North Carolina A&T | 5 | at | North Carolina-Greensboro | 3 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| The Citadel | 14 | at | Winthrop | 7 | FINAL | Box Score | Recap | |
| Southland Conference |
| 5/7/2008 |
| Louisiana Tech | 1 | at | Northwestern State | 7 | FINAL | Box Score | Recap | makeup of 4/2 game |
| 5/7/2008 |
| McNeese State | 4 | at | Louisiana-Lafayette | 5 | FINAL | Box Score | Recap | 10 innings |
| Southwestern Athletic Conference |
| 5/7/2008 |
| Grambling State | 10 | at | Alcorn State | 13 | FINAL | Box Score | | |
| 5/7/2008 |
| Tulane | 10 | at | Southern | 3 | FINAL | Box Score | Recap | |
| Summit League |
| 5/7/2008 |
| Minnesota | 4 | at | North Dakota State | 9 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Oral Roberts |
| at | Kansas |
| Canceled | | Recap | CCD, inclement weather |
| 5/7/2008 |
| Toledo | 19 | at | Oakland | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/7/2008 |
| Toledo |
| at | Oakland |
| Canceled | | Recap | CCD, rain |
| Sun Belt Conference |
| 5/7/2008 |
| Florida Gulf Coast | 7 | at | Florida Atlantic | 5 | FINAL | Box Score | Recap | 11 innings |
| 5/7/2008 |
| McNeese State | 4 | at | Louisiana-Lafayette | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/7/2008 |
| Mississippi State | 4 | at | Middle Tennessee State | 3 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 5/7/2008 |
| #18 St. Mary's | 6 | at | San Francisco | 5 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| Oregon State | 4 | vs | Portland | 1 | FINAL | Box Score | Recap | Resumption of 4/15 game (Corvallis, OR) |
| 5/7/2008 |
| Santa Clara | 7 | at | Pacific | 11 | FINAL | Box Score | Recap | |
| 5/7/2008 |
| UC Santa Barbara | 4 | at | Pepperdine | 5 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 5/7/2008 |
| Louisiana Tech | 1 | at | Northwestern State | 7 | FINAL | Box Score | Recap | makeup of 4/2 game |