| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/11/2008 | * | #2 North Carolina | 4 | at | #28 Virginia | 5 | FINAL | Box Score | Recap | 6 innings, rain |
| 5/11/2008 |
| Savannah State | 4 | at | #3 Florida State | 24 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 |
| Loyola Marymount | 3 | at | #4 Arizona State | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Houston | 6 | at | #5 Rice | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #6 Texas A&M | 8 | at | #7 Nebraska | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #6 Texas A&M | 10 | at | #7 Nebraska | 13 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 | * | Texas Tech | 12 | at | #8 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #9 San Diego | 3 | at | San Francisco | 14 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Pacific | 1 | at | #10 UC Irvine | 2 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #14 Georgia | 12 | at | #11 Vanderbilt | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #12 South Carolina | 2 | at | Arkansas | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #13 Wichita State | 16 | at | Evansville | 3 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | Cal Poly | 9 | at | #15 Cal State Fullerton | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #16 Missouri | 6 | at | Kansas | 7 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 | * | #16 Missouri | 12 | at | Kansas | 1 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | High Point | 3 | at | #17 Coastal Carolina | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #20 California | 5 | at | #18 Stanford | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Utah Valley State | 4 | at | #19 Arizona | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #21 North Carolina State | 17 | at | Maryland | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #22 Kentucky | 20 | at | Tennessee | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #23 Michigan | 11 | at | Minnesota | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #23 Michigan | 12 | at | Minnesota | 8 | FINAL | Box Score | Recap | 7 innings |
| 5/11/2008 | * | UC Santa Barbara | 5 | at | #25 Long Beach State | 3 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Mississippi State | 6 | at | #27 Louisiana State | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #29 North Carolina-Wilmington | 23 | at | James Madison | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Memphis | 0 | at | #30 Southern Mississippi | 13 | FINAL | Box Score | Recap | 7 innings, run rule |
| America East Conference |
| 5/11/2008 | * | Binghamton | 1 | at | Hartford | 5 | FINAL | Box Score | Recap | 7 innings (makeup of 5/9 game) |
| 5/11/2008 | * | Binghamton | 19 | at | Hartford | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Maine | 16 | at | Vermont | 5 | FINAL | Box Score | Recap | 7 innings |
| 5/11/2008 | * | Maine | 1 | at | Vermont | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Maryland-Baltimore County | 7 | at | Stony Brook | 4 | FINAL | Box Score | Recap | 8 innings (makeup of 5/9 game) |
| 5/11/2008 | * | Maryland-Baltimore County | 5 | at | Stony Brook | 16 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| New York Tech | 6 | at | Albany | 5 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 5/11/2008 | * | Dayton | 7 | at | Temple | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | George Washington | 8 | at | LaSalle | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Massachusetts | 2 | at | Rhode Island | 3 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | St. Bonaventure | 15 | at | St. Joseph's | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | St. Louis |
| at | Duquesne |
| Canceled | | Recap | CCD, inclement weather |
| 5/11/2008 | * | Xavier | 11 | at | Fordham | 3 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/11/2008 | * | #2 North Carolina | 4 | at | #28 Virginia | 5 | FINAL | Box Score | Recap | 6 innings, rain |
| 5/11/2008 |
| Savannah State | 4 | at | #3 Florida State | 24 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | #21 North Carolina State | 17 | at | Maryland | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Clemson | 16 | at | Georgia Tech | 6 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Duke | 4 | at | Wake Forest | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Northeastern | 6 | at | Boston College | 3 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/11/2008 | * | East Tennessee State | 2 | at | Florida Gulf Coast | 15 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | North Florida | 6 | at | Kennesaw State | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/11/2008 |
| Norfolk State | 9 | at | Gardner-Webb | 14 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Norfolk State | 5 | at | Gardner-Webb | 11 | FINAL | Box Score | Recap | 7 innings |
| Big 10 Conference |
| 5/11/2008 | * | #23 Michigan | 11 | at | Minnesota | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #23 Michigan | 12 | at | Minnesota | 8 | FINAL | Box Score | Recap | 7 innings |
| 5/11/2008 | * | Illinois |
| at | Ohio State |
| Canceled | | Recap | CCD, inclement weather |
| 5/11/2008 | * | Indiana | 14 | at | Northwestern | 12 | FINAL | Box Score | Recap | 10 innings |
| 5/11/2008 | * | Iowa | 8 | at | Penn State | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Michigan State |
| at | Purdue |
| Canceled | | Recap | CCD, rain |
| Big 12 Conference |
| 5/11/2008 | * | #6 Texas A&M | 8 | at | #7 Nebraska | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #6 Texas A&M | 10 | at | #7 Nebraska | 13 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 | * | Texas Tech | 12 | at | #8 Oklahoma State | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #16 Missouri | 6 | at | Kansas | 7 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 | * | #16 Missouri | 12 | at | Kansas | 1 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | Kansas State | 2 | at | Oklahoma | 10 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/11/2008 | * | Cincinnati | 7 | at | Seton Hall | 1 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Louisville | 4 | at | West Virginia | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/11/2008 | * | Pittsburgh |
| at | Notre Dame |
| Canceled | | Recap | CCD, rain |
| 5/11/2008 | * | South Florida | 9 | at | St. John's | 2 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Villanova | 2 | at | Rutgers | 1 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/11/2008 | * | High Point | 3 | at | #17 Coastal Carolina | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Charleston Southern | 7 | at | North Carolina-Asheville | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Longwood | 3 | at | Liberty | 3 | FINAL | Box Score | Recap | 6 innings, inclement weather |
| 5/11/2008 |
| Maryland-Eastern Shore | 6 | at | VMI | 7 | FINAL | Box Score | Recap | 8 innings, rain |
| Big West Conference |
| 5/11/2008 | * | Pacific | 1 | at | #10 UC Irvine | 2 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Cal Poly | 9 | at | #15 Cal State Fullerton | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | UC Santa Barbara | 5 | at | #25 Long Beach State | 3 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | UC Davis | 6 | at | UC Riverside | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Cal State Northridge | 2 | at | Southern California | 8 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/11/2008 | * | #29 North Carolina-Wilmington | 23 | at | James Madison | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Georgia State | 5 | at | Old Dominion | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Towson | 10 | at | Delaware | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Virginia Commonwealth | 7 | at | Hofstra | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Northeastern | 6 | at | Boston College | 3 | FINAL | Box Score | Recap | |
| Conference USA |
| 5/11/2008 | * | Houston | 6 | at | #5 Rice | 12 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Memphis | 0 | at | #30 Southern Mississippi | 13 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | Alabama-Birmingham | 14 | at | UCF | 3 | FINAL | Box Score | Recap | 7 innings, run rule |
| Division I Independents |
| 5/11/2008 |
| Savannah State | 4 | at | #3 Florida State | 24 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 |
| Utah Valley State | 4 | at | #19 Arizona | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Longwood | 3 | at | Liberty | 3 | FINAL | Box Score | Recap | 6 innings, inclement weather |
| 5/11/2008 |
| New York Tech | 6 | at | Albany | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Rider | 10 | at | LeMoyne | 15 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Texas-Pan American | 3 | at | Texas Christian | 13 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/11/2008 | * | Cleveland State | 2 | at | Illinois-Chicago | 6 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Cleveland State | 1 | at | Illinois-Chicago | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Valparaiso |
| at | Butler |
| Canceled | | Recap | CCD, rain |
| 5/11/2008 | * | Valparaiso |
| at | Butler |
| Canceled | | Recap | CCD, rain |
| Metro Atlantic Athletic Conference |
| 5/11/2008 | * | Canisius | 13 | at | Fairfield | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Iona | 4 | at | Siena | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Marist | 2 | at | Niagara | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | St. Peter's | 4 | at | Manhattan | 12 | FINAL | Box Score | Recap | 7 innings (makeup of 5/10 game) |
| 5/11/2008 | * | St. Peter's | 4 | at | Manhattan | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Rider | 10 | at | LeMoyne | 15 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 5/11/2008 | * | Kent State | 19 | at | Akron | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Northern Illinois |
| at | Ball State |
| Canceled | | Recap | CCD, rain |
| 5/11/2008 | * | Toledo |
| at | Eastern Michigan |
| Canceled | | Recap | CCD, rain |
| Mid-Eastern Athletic Conference |
| 5/11/2008 |
| Maryland-Eastern Shore | 6 | at | VMI | 7 | FINAL | Box Score | Recap | 8 innings, rain |
| 5/11/2008 |
| Norfolk State | 9 | at | Gardner-Webb | 14 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Norfolk State | 5 | at | Gardner-Webb | 11 | FINAL | Box Score | Recap | 7 innings |
| Missouri Valley Conference |
| 5/11/2008 | * | #13 Wichita State | 16 | at | Evansville | 3 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | Indiana State | 2 | at | Creighton | 5 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 | * | Indiana State | 4 | at | Creighton | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Northern Iowa | 4 | at | Bradley | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Middle Tennessee State | 3 | at | Missouri State | 4 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 |
| Middle Tennessee State | 6 | at | Missouri State | 7 | FINAL | Box Score | Recap | 900th career win for MSU's Keith Guttin (13 innings) |
| Mountain West Conference |
| 5/11/2008 | * | New Mexico | 15 | at | Nevada-Las Vegas | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Utah | 12 | at | Air Force | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Texas-Pan American | 3 | at | Texas Christian | 13 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/11/2008 | * | Fairleigh Dickinson | 5 | at | Monmouth | 8 | FINAL | Box Score | Recap | 7 innings (makeup of 5/9 game) |
| 5/11/2008 | * | Fairleigh Dickinson | 5 | at | Monmouth | 19 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Long Island | 7 | at | Mount St. Mary's | 4 | FINAL | Box Score | Recap | 10 innings (makeup of 5/9 game) |
| 5/11/2008 | * | Long Island |
| at | Mount St. Mary's |
| Canceled | | Recap | CCD, rain |
| 5/11/2008 | * | Quinnipiac | 12 | at | Sacred Heart | 0 | FINAL | Box Score | Recap | 7 innings (makeup of 5/9 game) |
| 5/11/2008 | * | Quinnipiac | 5 | at | Sacred Heart | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Wagner | 4 | at | Central Connecticut State | 5 | FINAL | Box Score | Recap | 10 innings (makeup of 5/9 game (New Britain, CT)) |
| 5/11/2008 | * | Wagner | 2 | at | Central Connecticut State | 5 | FINAL | Box Score | Recap | New Britain, CT |
| Ohio Valley Conference |
| 5/11/2008 | * | Austin Peay State |
| at | Eastern Illinois |
| Canceled | | Recap | CCD, rain |
| 5/11/2008 | * | Eastern Kentucky | 7 | at | Southeast Missouri State | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Morehead State | 3 | at | Samford | 17 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Tennessee Tech | 12 | at | Jacksonville State | 14 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Tennessee-Martin | 4 | at | Murray State | 13 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 5/11/2008 |
| Loyola Marymount | 3 | at | #4 Arizona State | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #20 California | 5 | at | #18 Stanford | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Utah Valley State | 4 | at | #19 Arizona | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | UCLA | 7 | at | Oregon State | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Washington State | 1 | at | Washington | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Cal State Northridge | 2 | at | Southern California | 8 | FINAL | Box Score | Recap | |
| Patriot League |
| 5/11/2008 | PATRIOT-06 | Holy Cross | 5 | vs | Navy | 9 | FINAL | Box Score | Recap | Patriot Semifinal, Game 3 (Annapolis, MD) |
| 5/11/2008 | PATRIOT-03 | Bucknell | 1 | vs | Army | 0 | FINAL | Box Score | Recap | Patriot Semifinal, Game 3 (West Point, NY) |
| Southeastern Conference |
| 5/11/2008 | * | #14 Georgia | 12 | at | #11 Vanderbilt | 10 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #12 South Carolina | 2 | at | Arkansas | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #22 Kentucky | 20 | at | Tennessee | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Mississippi State | 6 | at | #27 Louisiana State | 9 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Auburn | 2 | at | Mississippi | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Florida | 7 | at | Alabama | 8 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/11/2008 | * | Furman | 2 | at | Appalachian State | 4 | FINAL | Box Score | Recap | |
| Southland Conference |
| 5/11/2008 | * | Central Arkansas | 11 | at | Texas A&M-Corpus Christi | 11 | FINAL | Box Score | Recap | 9 innings, travel curfew |
| 5/11/2008 | * | Lamar | 3 | at | Northwestern State | 6 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Nicholls State | 2 | at | Texas-San Antonio | 5 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Sam Houston State | 2 | at | Southeastern Louisiana | 12 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/11/2008 | * | Texas State | 3 | at | McNeese State | 1 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Texas-Arlington | 1 | at | Stephen F. Austin | 9 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 5/11/2008 | * | Alcorn State | 15 | vs | Alabama A&M | 14 | FINAL | Box Score | | 10 innings (Meridian, MS (makeup of 4/5 game)) |
| 5/11/2008 |
| Stillman |
| at | Southern |
| Canceled | | | CCD, scheduling conflict |
| Summit League |
| 5/11/2008 | * | North Dakota State |
| at | Western Illinois |
| Postponed | | Recap | PPD to 5/12, inclement weather |
| 5/11/2008 | * | North Dakota State |
| at | Western Illinois |
| Postponed | | Recap | PPD to 5/12, inclement weather |
| 5/11/2008 | * | Oakland | 0 | at | Oral Roberts | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | South Dakota State |
| at | IUPU-Fort Wayne |
| Canceled | | Recap | CCD, rain |
| Sun Belt Conference |
| 5/11/2008 | * | Arkansas State | 11 | at | Florida Atlantic | 11 | FINAL | Box Score | Recap | 6 innings, travel curfew |
| 5/11/2008 | * | Louisiana-Lafayette | 4 | at | Western Kentucky | 13 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | New Orleans | 12 | at | Arkansas-Little Rock | 4 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | South Alabama | 4 | at | Florida International | 7 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Troy | 5 | at | Louisiana-Monroe | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 |
| Middle Tennessee State | 3 | at | Missouri State | 4 | FINAL | Box Score | Recap | makeup of 5/10 game |
| 5/11/2008 |
| Middle Tennessee State | 6 | at | Missouri State | 7 | FINAL | Box Score | Recap | 900th career win for MSU's Keith Guttin (13 innings) |
| West Coast Conference |
| 5/11/2008 |
| Loyola Marymount | 3 | at | #4 Arizona State | 11 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | #9 San Diego | 3 | at | San Francisco | 14 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | Portland | 5 | at | Pepperdine | 8 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | St. Mary's | 6 | at | Santa Clara | 14 | FINAL | Box Score | Recap | |
| Western Athletic Conference |
| 5/11/2008 | * | Cal State Sacramento | 12 | at | Nevada | 13 | FINAL | Box Score | Recap | |
| 5/11/2008 | * | San Jose State | 2 | at | Fresno State | 1 | FINAL | Box Score | Recap | |