| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/13/2008 |
| North Florida | 2 | at | #1 Miami, Florida | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Winthrop | 1 | at | #2 North Carolina | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #6 Nebraska | 8 | at | Creighton | 1 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #7 Texas A&M | 8 | at | Texas-Arlington | 16 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Western Illinois | 1 | at | #8 Oklahoma State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| UCLA | 6 | at | #9 UC Irvine | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #29 Georgia Tech | 2 | vs | #12 Georgia | 3 | FINAL | Box Score | Recap | Atlanta, GA |
| 5/13/2008 |
| #17 California | 5 | at | UC Davis | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Oral Roberts | 12 | at | #18 Wichita State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| The Citadel | 2 | at | #19 South Carolina | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #22 Michigan | 15 | vs | Notre Dame | 12 | FINAL | Box Score | Recap | Grand Rapids, MI |
| 5/13/2008 |
| North Carolina A&T | 6 | at | #23 North Carolina State | 17 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| New Orleans | 6 | vs | #24 Louisiana State | 7 | FINAL | Box Score | Recap | 15 innings (Wally Pontiff Jr. Classic, Metairie, LA) |
| 5/13/2008 |
| #25 Long Beach State | 10 | at | San Diego State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #26 North Carolina-Wilmington | 2 | at | #30 East Carolina | 3 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #27 Southern Mississippi | 5 | at | South Alabama | 16 | FINAL | Box Score | Recap | 7 innings, run rule |
| America East Conference |
| 5/13/2008 |
| Georgetown |
| at | Maryland-Baltimore County |
| Canceled | | Recap | CCD, field conditions |
| 5/13/2008 |
| Seton Hall | 7 | at | Stony Brook | 8 | FINAL | Box Score | Recap | |
| Atlantic 10 Conference |
| 5/13/2008 |
| Duquesne | 7 | at | Cleveland State | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Eastern Kentucky | 10 | at | Dayton | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| LaSalle |
| at | Rider |
| Canceled | | Recap | CCD, field conditions |
| 5/13/2008 |
| Massachusetts | 2 | at | Quinnipiac | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Mount St. Mary's | 11 | at | George Washington | 12 | FINAL | Box Score | Recap | makeup of 3/19 game |
| 5/13/2008 |
| New Jersey Tech | 13 | at | St. Joseph's | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Niagara | 2 | at | St. Bonaventure | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Rhode Island | 10 | at | Northeastern | 2 | FINAL | Box Score | Recap | 7 innings |
| 5/13/2008 |
| Rhode Island | 3 | at | Northeastern | 8 | FINAL | Box Score | Recap | 7 innings |
| 5/13/2008 |
| Richmond | 2 | at | Old Dominion | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| St. Louis | 1 | vs | Southern Illinois | 2 | FINAL | Box Score | Recap | 11 innings (Sauget, IL) |
| 5/13/2008 |
| Temple | 14 | at | Villanova | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Xavier | 5 | at | Bowling Green State | 6 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/13/2008 |
| North Florida | 2 | at | #1 Miami, Florida | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Winthrop | 1 | at | #2 North Carolina | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #29 Georgia Tech | 2 | vs | #12 Georgia | 3 | FINAL | Box Score | Recap | Atlanta, GA |
| 5/13/2008 |
| North Carolina A&T | 6 | at | #23 North Carolina State | 17 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Campbell | 5 | at | Duke | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| College of Charleston | 6 | at | Clemson | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Connecticut | 9 | at | Boston College | 11 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Maryland | 4 | at | Delaware | 0 | FINAL | Box Score | Recap | No-hitter for UM's Scott Swinson |
| 5/13/2008 |
| VMI | 5 | at | Virginia | 6 | FINAL | Box Score | Recap | 11 innings |
| 5/13/2008 |
| Wake Forest | 15 | at | Elon | 16 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| William and Mary | 5 | at | Virginia Tech | 10 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/13/2008 |
| North Florida | 2 | at | #1 Miami, Florida | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Auburn | 18 | at | Mercer | 6 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Austin Peay State | 2 | at | Lipscomb | 7 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Campbell | 5 | at | Duke | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Florida Atlantic | 1 | at | Florida Gulf Coast | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Georgia Southern | 4 | at | Jacksonville | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Jacksonville State | 12 | at | Kennesaw State | 11 | FINAL | Box Score | Recap | 11 innings |
| 5/13/2008 |
| South Carolina-Upstate | 5 | at | High Point | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/13/2008 |
| Tennessee-Martin | 5 | at | Belmont | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Western Carolina |
| at | East Tennessee State |
| Canceled | | Recap | CCD, scheduling conflict |
| Big 10 Conference |
| 5/13/2008 |
| #22 Michigan | 15 | vs | Notre Dame | 12 | FINAL | Box Score | Recap | Grand Rapids, MI |
| 5/13/2008 |
| Buffalo | 13 | at | Ohio State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Butler | 5 | at | Indiana | 13 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Michigan State | 6 | at | Central Michigan | 14 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 5/13/2008 |
| #6 Nebraska | 8 | at | Creighton | 1 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #7 Texas A&M | 8 | at | Texas-Arlington | 16 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Western Illinois | 1 | at | #8 Oklahoma State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Dallas Baptist | 8 | at | Texas Tech | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Dallas Baptist | 8 | at | Texas Tech | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Texas State | 2 | at | Baylor | 7 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/13/2008 |
| #22 Michigan | 15 | vs | Notre Dame | 12 | FINAL | Box Score | Recap | Grand Rapids, MI |
| 5/13/2008 |
| Akron | 4 | at | Pittsburgh | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Ball State | 3 | at | Louisville | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Connecticut | 9 | at | Boston College | 11 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Georgetown |
| at | Maryland-Baltimore County |
| Canceled | | Recap | CCD, field conditions |
| 5/13/2008 |
| Seton Hall | 7 | at | Stony Brook | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| South Florida | 2 | at | Florida | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Temple | 14 | at | Villanova | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Wright State | 7 | at | Cincinnati | 13 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/13/2008 |
| Winthrop | 1 | at | #2 North Carolina | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Appalachian State | 9 | at | North Carolina-Asheville | 3 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Radford | 3 | at | Longwood | 1 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| South Carolina-Upstate | 5 | at | High Point | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/13/2008 |
| Virginia Commonwealth | 3 | at | Liberty | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| VMI | 5 | at | Virginia | 6 | FINAL | Box Score | Recap | 11 innings |
| Big West Conference |
| 5/13/2008 |
| UCLA | 6 | at | #9 UC Irvine | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #17 California | 5 | at | UC Davis | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #25 Long Beach State | 10 | at | San Diego State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Nevada-Las Vegas | 5 | at | UC Riverside | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Pepperdine | 8 | at | Cal Poly | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Portland | 9 | at | Cal State Northridge | 4 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/13/2008 |
| #26 North Carolina-Wilmington | 2 | at | #30 East Carolina | 3 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Georgia State | 8 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Maryland | 4 | at | Delaware | 0 | FINAL | Box Score | Recap | No-hitter for UM's Scott Swinson |
| 5/13/2008 |
| Rhode Island | 10 | at | Northeastern | 2 | FINAL | Box Score | Recap | 7 innings |
| 5/13/2008 |
| Rhode Island | 3 | at | Northeastern | 8 | FINAL | Box Score | Recap | 7 innings |
| 5/13/2008 |
| Richmond | 2 | at | Old Dominion | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Virginia Commonwealth | 3 | at | Liberty | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| William and Mary | 5 | at | Virginia Tech | 10 | FINAL | Box Score | Recap | |
| Conference USA |
| 5/13/2008 |
| #26 North Carolina-Wilmington | 2 | at | #30 East Carolina | 3 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #27 Southern Mississippi | 5 | at | South Alabama | 16 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/13/2008 |
| Alabama-Birmingham | 13 | at | Troy | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Houston | 14 | at | Texas-San Antonio | 4 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/13/2008 |
| Memphis | 1 | at | Mississippi State | 4 | FINAL | Box Score | Recap | |
| Division I Independents |
| 5/13/2008 |
| Dallas Baptist | 8 | at | Texas Tech | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Dallas Baptist | 8 | at | Texas Tech | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Georgia State | 8 | at | Presbyterian | 7 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| New Jersey Tech | 13 | at | St. Joseph's | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Radford | 3 | at | Longwood | 1 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Utah Valley State | 4 | at | Oregon State | 8 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/13/2008 |
| Butler | 5 | at | Indiana | 13 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Cedarville | 6 | at | Valparaiso | 13 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Duquesne | 7 | at | Cleveland State | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Kent State | 9 | at | Youngstown State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Wright State | 7 | at | Cincinnati | 13 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 5/13/2008 |
| LaSalle |
| at | Rider |
| Canceled | | Recap | CCD, field conditions |
| 5/13/2008 |
| Niagara | 2 | at | St. Bonaventure | 10 | FINAL | Box Score | Recap | |
| Mid American Conference |
| 5/13/2008 |
| Akron | 4 | at | Pittsburgh | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Ball State | 3 | at | Louisville | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Buffalo | 13 | at | Ohio State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Illinois State | 4 | at | Western Michigan | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/13/2008 |
| Kent State | 9 | at | Youngstown State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Miami, Ohio | 12 | at | Indiana State | 17 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Michigan State | 6 | at | Central Michigan | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Oakland | 7 | at | Eastern Michigan | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Xavier | 5 | at | Bowling Green State | 6 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/13/2008 |
| North Carolina A&T | 6 | at | #23 North Carolina State | 17 | FINAL | Box Score | Recap | |
| Missouri Valley Conference |
| 5/13/2008 |
| #6 Nebraska | 8 | at | Creighton | 1 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Oral Roberts | 12 | at | #18 Wichita State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Evansville | 4 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Illinois State | 4 | at | Western Michigan | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/13/2008 |
| Miami, Ohio | 12 | at | Indiana State | 17 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| St. Louis | 1 | vs | Southern Illinois | 2 | FINAL | Box Score | Recap | 11 innings (Sauget, IL) |
| Mountain West Conference |
| 5/13/2008 |
| #25 Long Beach State | 10 | at | San Diego State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Nevada-Las Vegas | 5 | at | UC Riverside | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Southern Utah | 6 | at | Utah | 7 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/13/2008 |
| Massachusetts | 2 | at | Quinnipiac | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Mount St. Mary's | 11 | at | George Washington | 12 | FINAL | Box Score | Recap | makeup of 3/19 game |
| 5/13/2008 |
| Sacred Heart | 12 | at | Army | 27 | FINAL | Box Score | Recap | |
| Ohio Valley Conference |
| 5/13/2008 |
| Arkansas State | 5 | at | Murray State | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Austin Peay State | 2 | at | Lipscomb | 7 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Central Arkansas | 4 | at | Southeast Missouri State | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Eastern Kentucky | 10 | at | Dayton | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Evansville | 4 | at | Eastern Illinois | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Jacksonville State | 12 | at | Kennesaw State | 11 | FINAL | Box Score | Recap | 11 innings |
| 5/13/2008 |
| Tennessee-Martin | 5 | at | Belmont | 12 | FINAL | Box Score | Recap | |
| Pac 10 Conference |
| 5/13/2008 |
| UCLA | 6 | at | #9 UC Irvine | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| #17 California | 5 | at | UC Davis | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Lewis-Clark State |
| at | Washington |
| Postponed | | Recap | PPD to 5/20, scheduling conflict |
| 5/13/2008 |
| Utah Valley State | 4 | at | Oregon State | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Washington State | 7 | at | Gonzaga | 5 | FINAL | Box Score | Recap | 11 innings |
| Patriot League |
| 5/13/2008 |
| Sacred Heart | 12 | at | Army | 27 | FINAL | Box Score | Recap | |
| Southeastern Conference |
| 5/13/2008 |
| #29 Georgia Tech | 2 | vs | #12 Georgia | 3 | FINAL | Box Score | Recap | Atlanta, GA |
| 5/13/2008 |
| The Citadel | 2 | at | #19 South Carolina | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| New Orleans | 6 | vs | #24 Louisiana State | 7 | FINAL | Box Score | Recap | 15 innings (Wally Pontiff Jr. Classic, Metairie, LA) |
| 5/13/2008 |
| Auburn | 18 | at | Mercer | 6 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Memphis | 1 | at | Mississippi State | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| South Florida | 2 | at | Florida | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Tennessee | 4 | at | Furman | 2 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/13/2008 |
| The Citadel | 2 | at | #19 South Carolina | 10 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Appalachian State | 9 | at | North Carolina-Asheville | 3 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| College of Charleston | 6 | at | Clemson | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Georgia Southern | 4 | at | Jacksonville | 9 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Tennessee | 4 | at | Furman | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Wake Forest | 15 | at | Elon | 16 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Western Carolina |
| at | East Tennessee State |
| Canceled | | Recap | CCD, scheduling conflict |
| Southland Conference |
| 5/13/2008 |
| #7 Texas A&M | 8 | at | Texas-Arlington | 16 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Central Arkansas | 4 | at | Southeast Missouri State | 12 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Houston | 14 | at | Texas-San Antonio | 4 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/13/2008 |
| Texas State | 2 | at | Baylor | 7 | FINAL | Box Score | Recap | |
| Summit League |
| 5/13/2008 |
| Western Illinois | 1 | at | #8 Oklahoma State | 14 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Oral Roberts | 12 | at | #18 Wichita State | 0 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Oakland | 7 | at | Eastern Michigan | 8 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Southern Utah | 6 | at | Utah | 7 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 5/13/2008 |
| New Orleans | 6 | vs | #24 Louisiana State | 7 | FINAL | Box Score | Recap | 15 innings (Wally Pontiff Jr. Classic, Metairie, LA) |
| 5/13/2008 |
| #27 Southern Mississippi | 5 | at | South Alabama | 16 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/13/2008 |
| Alabama-Birmingham | 13 | at | Troy | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Arkansas State | 5 | at | Murray State | 2 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Florida Atlantic | 1 | at | Florida Gulf Coast | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Louisiana-Monroe | 5 | at | Louisiana Tech | 15 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 5/13/2008 |
| Pepperdine | 8 | at | Cal Poly | 5 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Portland | 9 | at | Cal State Northridge | 4 | FINAL | Box Score | Recap | |
| 5/13/2008 |
| Washington State | 7 | at | Gonzaga | 5 | FINAL | Box Score | Recap | 11 innings |
| Western Athletic Conference |
| 5/13/2008 |
| Louisiana-Monroe | 5 | at | Louisiana Tech | 15 | FINAL | Box Score | Recap | |