| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/16/2008 | * | #2 North Carolina | 10 | at | #1 Miami, Florida | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #23 North Carolina State | 0 | at | #3 Florida State | 1 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Washington | 3 | at | #4 Arizona State | 13 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #5 Rice | 8 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #5 Rice | 6 | at | Tulane | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #6 Nebraska | 1 | at | #15 Missouri | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #7 Texas A&M | 2 | at | #28 Texas | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #8 Oklahoma State | 7 | vs | Oklahoma | 1 | FINAL | Box Score | Recap | Tulsa, OK |
| 5/16/2008 | * | #9 UC Irvine | 1 | at | UC Davis | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| San Diego State | 3 | at | #11 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Alabama | 17 | at | #12 Georgia | 13 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Alabama | 4 | at | #12 Georgia | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #13 Vanderbilt | 4 | at | Florida | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #14 Coastal Carolina | 10 | at | Radford | 4 | FINAL | Box Score | Recap | Pulaski, VA |
| 5/16/2008 | * | Bradley | 3 | at | #18 Wichita State | 9 | FINAL | Box Score | Recap | WSU's Dusty Coleman hits for cycle |
| 5/16/2008 | * | Tennessee | 5 | at | #19 South Carolina | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Mississippi | 0 | at | #20 Kentucky | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Northwestern | 1 | at | #22 Michigan | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Northwestern | 2 | at | #22 Michigan | 0 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | #24 Louisiana State | 15 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #25 Long Beach State | 7 | at | Cal Poly | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Old Dominion | 9 | at | #26 North Carolina-Wilmington | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #27 Southern Mississippi | 0 | at | Alabama-Birmingham | 6 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | #27 Southern Mississippi | 8 | at | Alabama-Birmingham | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #29 Georgia Tech | 14 | at | Virginia | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #30 East Carolina | 17 | at | Memphis | 3 | FINAL | Box Score | Recap | |
| America East Conference |
| 5/16/2008 | * | Maine |
| at | Binghamton |
| Postponed | | | PPD to 5/17, rain |
| 5/16/2008 | * | Maine |
| at | Binghamton |
| Canceled | | | CCD, rain |
| 5/16/2008 | * | Stony Brook | 7 | at | Albany | 2 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Stony Brook | 2 | at | Albany | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Vermont |
| at | Hartford |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| 5/16/2008 | * | Vermont |
| at | Hartford |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| Atlantic 10 Conference |
| 5/16/2008 | * | Duquesne | 10 | at | Dayton | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Fordham | 4 | at | Massachusetts | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | George Washington | 8 | at | Xavier | 9 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | George Washington | 1 | at | Xavier | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Rhode Island | 2 | at | North Carolina-Charlotte | 8 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Rhode Island | 7 | at | North Carolina-Charlotte | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | St. Bonaventure | 14 | at | Richmond | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | St. Joseph's |
| at | LaSalle |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| 5/16/2008 | * | Temple | 7 | at | St. Louis | 6 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Temple | 2 | at | St. Louis | 5 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/16/2008 | * | #2 North Carolina | 10 | at | #1 Miami, Florida | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #23 North Carolina State | 0 | at | #3 Florida State | 1 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #29 Georgia Tech | 14 | at | Virginia | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Duke | 5 | at | Virginia Tech | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Wake Forest | 2 | at | Boston College | 0 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Clemson | 7 | at | UCF | 3 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/16/2008 | * | Belmont | 12 | at | Mercer | 1 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Belmont | 2 | at | Mercer | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Florida Gulf Coast | 9 | at | South Carolina-Upstate | 0 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Florida Gulf Coast | 3 | at | South Carolina-Upstate | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Kennesaw State | 10 | at | Jacksonville | 0 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Kennesaw State | 8 | at | Jacksonville | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Lipscomb | 5 | at | Campbell | 10 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Lipscomb | 6 | at | Campbell | 1 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | North Florida | 6 | at | Gardner-Webb | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | North Florida | 8 | at | Gardner-Webb | 0 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Stetson | 18 | at | East Tennessee State | 12 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 5/16/2008 | * | Northwestern | 1 | at | #22 Michigan | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Northwestern | 2 | at | #22 Michigan | 0 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Indiana | 7 | at | Michigan State | 6 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Indiana | 7 | at | Michigan State | 3 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Ohio State | 12 | at | Iowa | 2 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Ohio State | 4 | at | Iowa | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Penn State | 5 | at | Minnesota | 3 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Penn State | 9 | at | Minnesota | 7 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Purdue | 14 | at | Illinois | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Purdue | 13 | at | Illinois | 8 | FINAL | Box Score | Recap | 7 innings |
| Big 12 Conference |
| 5/16/2008 | * | #6 Nebraska | 1 | at | #15 Missouri | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #7 Texas A&M | 2 | at | #28 Texas | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #8 Oklahoma State | 7 | vs | Oklahoma | 1 | FINAL | Box Score | Recap | Tulsa, OK |
| 5/16/2008 | * | Baylor | 4 | at | Texas Tech | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Kansas State | 5 | at | Kansas | 0 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/16/2008 | * | Connecticut |
| at | Pittsburgh |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| 5/16/2008 | * | Notre Dame | 2 | at | South Florida | 3 | FINAL | Box Score | Recap | 16 innings |
| 5/16/2008 | * | Rutgers | 1 | at | Louisville | 3 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Rutgers | 3 | at | Louisville | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Seton Hall |
| at | Georgetown |
| Postponed | | Recap | PPD to 5/17, field conditions |
| 5/16/2008 | * | St. John's |
| at | Villanova |
| Postponed | | Recap | PPD to 5/17, rain |
| 5/16/2008 | * | West Virginia | 5 | at | Cincinnati | 14 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | West Virginia | 1 | at | Cincinnati | 9 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/16/2008 | * | #14 Coastal Carolina | 10 | at | Radford | 4 | FINAL | Box Score | Recap | Pulaski, VA |
| 5/16/2008 | * | Charleston Southern | 3 | at | VMI | 14 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | High Point | 1 | at | Liberty | 8 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Winthrop | 13 | at | North Carolina-Asheville | 12 | FINAL | Box Score | Recap | 800th career win for Winthrop's Joe Hudak (10 innings) |
| Big West Conference |
| 5/16/2008 | * | #9 UC Irvine | 1 | at | UC Davis | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| San Diego State | 3 | at | #11 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #25 Long Beach State | 7 | at | Cal Poly | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Cal State Northridge | 5 | at | Pacific | 17 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | UC Riverside | 2 | at | UC Santa Barbara | 13 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/16/2008 | * | Old Dominion | 9 | at | #26 North Carolina-Wilmington | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Delaware |
| at | Virginia Commonwealth |
| Canceled | | Recap | CCD, rain |
| 5/16/2008 | * | Delaware |
| at | Virginia Commonwealth |
| Canceled | | Recap | CCD, rain (moved from 5/17, impending weather) |
| 5/16/2008 | * | Georgia State | 3 | at | Towson | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | James Madison | 10 | at | Northeastern | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | William and Mary |
| at | George Mason |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| Conference USA |
| 5/16/2008 | * | #5 Rice | 8 | at | Tulane | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #5 Rice | 6 | at | Tulane | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #27 Southern Mississippi | 0 | at | Alabama-Birmingham | 6 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | #27 Southern Mississippi | 8 | at | Alabama-Birmingham | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #30 East Carolina | 17 | at | Memphis | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Marshall | 3 | at | Houston | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Clemson | 7 | at | UCF | 3 | FINAL | Box Score | Recap | |
| Division I Independents |
| 5/16/2008 |
| Dallas Baptist | 11 | at | San Francisco | 7 | FINAL | Box Score | Recap | 10 innings |
| 5/16/2008 |
| LeMoyne |
| at | Iona |
| Canceled | | Recap | CCD, rain |
| 5/16/2008 |
| New Jersey Tech | 3 | at | Wright State | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Northern Colorado |
| at | New York Tech |
| Canceled | | Recap | CCD, rain |
| 5/16/2008 |
| Presbyterian | 6 | at | The Citadel | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Utah Valley State | 6 | at | Hawaii | 9 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/16/2008 | * | Cleveland State | 3 | at | Butler | 1 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Valparaiso | 4 | at | Illinois-Chicago | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Youngstown State | 8 | at | Wisconsin-Milwaukee | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| New Jersey Tech | 3 | at | Wright State | 9 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 5/16/2008 | * | Canisius | 7 | at | Niagara | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Manhattan |
| at | Fairfield |
| Postponed | | Recap | PPD to 5/17, rain |
| 5/16/2008 | * | Rider |
| at | St. Peter's |
| Postponed | | Recap | PPD, inclement weather |
| 5/16/2008 | * | Siena |
| at | Marist |
| Canceled | | Recap | CCD, rain |
| 5/16/2008 |
| LeMoyne |
| at | Iona |
| Canceled | | Recap | CCD, rain |
| Mid American Conference |
| 5/16/2008 | * | Ball State | 3 | at | Toledo | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Bowling Green State | 12 | at | Akron | 7 | FINAL | Box Score | Recap | 11 innings |
| 5/16/2008 | * | Eastern Michigan | 9 | at | Central Michigan | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Kent State | 6 | at | Miami, Ohio | 3 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Kent State | 16 | at | Miami, Ohio | 17 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Ohio | 4 | at | Buffalo | 5 | FINAL | Box Score | Recap | 10 innings |
| 5/16/2008 | * | Western Michigan | 8 | at | Northern Illinois | 4 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/16/2008 | MEAC-06 | Norfolk State | 5 | vs | Delaware State | 1 | FINAL | Box Score | Recap | MEAC Tournament, Game 6 (Norfolk, VA) |
| 5/16/2008 | MEAC-05 | Florida A&M | 5 | vs | North Carolina A&T | 6 | FINAL | Box Score | Recap | MEAC Tournament, Game 5 (Norfolk, VA) |
| 5/16/2008 | MEAC-04 | Norfolk State | 7 | vs | Maryland-Eastern Shore | 2 | FINAL | Box Score | Recap | MEAC Tournament, Game 4 (Norfolk, VA) |
| Missouri Valley Conference |
| 5/16/2008 | * | Bradley | 3 | at | #18 Wichita State | 9 | FINAL | Box Score | Recap | WSU's Dusty Coleman hits for cycle |
| 5/16/2008 | * | Evansville | 2 | at | Southern Illinois | 8 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Evansville | 2 | at | Southern Illinois | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Illinois State | 0 | at | Indiana State | 4 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Illinois State | 1 | at | Indiana State | 11 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Missouri State | 3 | at | Northern Iowa | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Louisiana-Monroe | 3 | at | Creighton | 8 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 5/16/2008 |
| San Diego State | 3 | at | #11 Cal State Fullerton | 10 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Brigham Young | 15 | at | Utah | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Nevada-Las Vegas | 8 | at | Air Force | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Texas Christian | 8 | at | New Mexico | 3 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Texas Christian | 14 | at | New Mexico | 11 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/16/2008 | * | Central Connecticut State |
| at | Fairleigh Dickinson |
| Postponed | | Recap | PPD to 5/18, inclement weather |
| 5/16/2008 | * | Monmouth |
| at | Long Island |
| Postponed | | Recap | PPD to 5/18, rain |
| 5/16/2008 | * | Mount St. Mary's |
| at | Quinnipiac |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| 5/16/2008 | * | Mount St. Mary's |
| at | Quinnipiac |
| Postponed | | Recap | PPD to 5/17, inclement weather |
| 5/16/2008 | * | Sacred Heart |
| at | Wagner |
| Postponed | | Recap | PPD to 5/18, inclement weather |
| Ohio Valley Conference |
| 5/16/2008 | * | Eastern Illinois | 4 | at | Eastern Kentucky | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Eastern Illinois | 3 | at | Eastern Kentucky | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Jacksonville State | 10 | at | Tennessee-Martin | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Jacksonville State | 5 | at | Tennessee-Martin | 0 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Murray State | 2 | at | Austin Peay State | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Murray State | 2 | at | Austin Peay State | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Samford | 5 | at | Tennessee Tech | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Samford | 2 | at | Tennessee Tech | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Southeast Missouri State | 8 | at | Morehead State | 10 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Southeast Missouri State | 9 | at | Morehead State | 6 | FINAL | Box Score | Recap | 7 innings |
| Pac 10 Conference |
| 5/16/2008 | * | Washington | 3 | at | #4 Arizona State | 13 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Oregon State | 3 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Washington State | 0 | at | UCLA | 10 | FINAL | Box Score | Recap | |
| Patriot League |
| 5/16/2008 | PATRIOT-07 | Bucknell | 7 | vs | Navy | 6 | FINAL | Box Score | Recap | Patriot Championship, Game 1 (Annapolis, MD) |
| Southeastern Conference |
| 5/16/2008 | * | Alabama | 17 | at | #12 Georgia | 13 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Alabama | 4 | at | #12 Georgia | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #13 Vanderbilt | 4 | at | Florida | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Tennessee | 5 | at | #19 South Carolina | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Mississippi | 0 | at | #20 Kentucky | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | #24 Louisiana State | 15 | at | Auburn | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Arkansas | 5 | at | Mississippi State | 6 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/16/2008 | * | Appalachian State | 7 | at | Wofford | 12 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | College of Charleston | 10 | at | Western Carolina | 4 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | College of Charleston | 20 | at | Western Carolina | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Davidson | 6 | at | North Carolina-Greensboro | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Georgia Southern | 2 | at | Furman | 10 | FINAL | Box Score | Recap | makeup of 5/15 game |
| 5/16/2008 | * | Georgia Southern | 6 | at | Furman | 3 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Presbyterian | 6 | at | The Citadel | 9 | FINAL | Box Score | Recap | |
| Southland Conference |
| 5/16/2008 | * | McNeese State | 10 | at | Lamar | 11 | FINAL | Box Score | Recap | 1,100th career win for Lamar's Jim Gilligan (11 innings) |
| 5/16/2008 | * | Northwestern State | 2 | at | Central Arkansas | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Southeastern Louisiana |
| at | Nicholls State |
| Postponed | | Recap | PPD to 5/17, field conditions |
| 5/16/2008 | * | Stephen F. Austin | 8 | at | Sam Houston State | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Texas A&M-Corpus Christi | 4 | at | Texas-Arlington | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Texas-San Antonio | 3 | at | Texas State | 0 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 5/16/2008 | SWAC-07 | Texas Southern | 13 | vs | Mississippi Valley State | 3 | FINAL | Box Score | Recap | 7 innings; SWAC Tournament, Game 7 (Baton Rouge, LA) |
| 5/16/2008 | SWAC-06 | Alcorn State | 15 | vs | Alabama State | 4 | FINAL | Box Score | Recap | 8 innings; SWAC Tournament, Game 6 (Baton Rouge, LA) |
| 5/16/2008 | SWAC-05 | Grambling State | 4 | vs | Jackson State | 7 | FINAL | Box Score | Recap | SWAC Tournament, Game 5 (Baton Rouge, LA) |
| Summit League |
| 5/16/2008 | * | Oral Roberts | 4 | at | IUPU-Fort Wayne | 2 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Oral Roberts | 9 | at | IUPU-Fort Wayne | 1 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | South Dakota State | 3 | at | North Dakota State | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | South Dakota State | 7 | at | North Dakota State | 5 | FINAL | Box Score | Recap | 8 innings |
| 5/16/2008 | * | Southern Utah | 6 | at | Oakland | 17 | FINAL | Box Score | Recap | OU ties NCAA record with 11 hits in 8th inning |
| 5/16/2008 | * | Southern Utah | 8 | at | Oakland | 3 | FINAL | Box Score | Recap | 7 innings |
| 5/16/2008 | * | Western Illinois | 8 | at | Centenary | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Western Illinois | 1 | at | Centenary | 6 | FINAL | Box Score | Recap | 7 innings |
| Sun Belt Conference |
| 5/16/2008 | * | Arkansas-Little Rock | 15 | at | Arkansas State | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Florida Atlantic | 7 | at | Florida International | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Middle Tennessee State | 5 | at | Western Kentucky | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | New Orleans | 8 | at | Louisiana-Lafayette | 11 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | South Alabama | 7 | at | Troy | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Louisiana-Monroe | 3 | at | Creighton | 8 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 5/16/2008 | * | Gonzaga | 7 | at | Loyola Marymount | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Pepperdine | 3 | at | Santa Clara | 6 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | St. Mary's | 10 | at | Portland | 5 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Dallas Baptist | 11 | at | San Francisco | 7 | FINAL | Box Score | Recap | 10 innings |
| Western Athletic Conference |
| 5/16/2008 | * | Fresno State | 8 | at | Cal State Sacramento | 9 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Louisiana Tech | 11 | at | New Mexico State | 14 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Louisiana Tech | 5 | at | New Mexico State | 4 | FINAL | Box Score | Recap | |
| 5/16/2008 | * | Nevada | 4 | at | San Jose State | 7 | FINAL | Box Score | Recap | |
| 5/16/2008 |
| Utah Valley State | 6 | at | Hawaii | 9 | FINAL | Box Score | Recap | |