| Game Date | Conference | Road Team | Score |
| Home Team | Score | Status | Box Score | Recap | Commentary |
| National Collegiate Baseball Writers Poll |
| 5/17/2008 | * | #2 North Carolina | 12 | at | #1 Miami, Florida | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #23 North Carolina State | 1 | at | #3 Florida State | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Washington | 4 | at | #4 Arizona State | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #6 Nebraska | 9 | at | #15 Missouri | 22 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #28 Texas | 5 | at | #7 Texas A&M | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #8 Oklahoma State | 11 | vs | Oklahoma | 1 | FINAL | Box Score | Recap | Oklahoma City, OK |
| 5/17/2008 | * | #9 UC Irvine | 4 | at | UC Davis | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| San Diego State | 5 | at | #11 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Alabama | 16 | at | #12 Georgia | 13 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #13 Vanderbilt | 12 | at | Florida | 13 | FINAL | Box Score | Recap | 11 innings |
| 5/17/2008 | * | #14 Coastal Carolina | 18 | at | Radford | 8 | FINAL | Box Score | Recap | 500th win at CCU for Gary Gilmore |
| 5/17/2008 | * | #21 Stanford | 6 | at | #16 Arizona | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Bradley | 5 | at | #18 Wichita State | 21 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/17/2008 | * | Tennessee | 8 | at | #19 South Carolina | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Mississippi | 7 | at | #20 Kentucky | 5 | FINAL | Box Score | Recap | 11 innings |
| 5/17/2008 | * | Northwestern | 2 | at | #22 Michigan | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #24 Louisiana State | 11 | at | Auburn | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #25 Long Beach State | 6 | at | Cal Poly | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Old Dominion | 3 | at | #26 North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #27 Southern Mississippi | 2 | at | Alabama-Birmingham | 12 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/17/2008 | * | #29 Georgia Tech | 9 | at | Virginia | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #30 East Carolina | 5 | at | Memphis | 7 | FINAL | Box Score | Recap | |
| America East Conference |
| 5/17/2008 | * | Maine | 5 | at | Binghamton | 6 | FINAL | Box Score | Recap | 10 innings (makeup of 5/16 game) |
| 5/17/2008 | * | Maine | 7 | at | Binghamton | 6 | FINAL | Box Score | Recap | 7 innings |
| 5/17/2008 | * | Stony Brook | 6 | at | Albany | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Vermont | 3 | at | Hartford | 2 | FINAL | Box Score | Recap | 7 innings |
| 5/17/2008 | * | Vermont | 3 | at | Hartford | 1 | FINAL | Box Score | Recap | 7 innings (makeup of 5/16 game) |
| Atlantic 10 Conference |
| 5/17/2008 | * | Duquesne | 11 | at | Dayton | 13 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Fordham | 13 | at | Massachusetts | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | George Washington | 5 | at | Xavier | 6 | FINAL | Box Score | Recap | 15 innings |
| 5/17/2008 | * | Rhode Island | 1 | at | North Carolina-Charlotte | 2 | FINAL | Box Score | Recap | 10 innings |
| 5/17/2008 | * | St. Bonaventure | 5 | at | Richmond | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | St. Joseph's | 12 | at | LaSalle | 13 | FINAL | Box Score | Recap | 10 innings (makeup of 5/16 game) |
| 5/17/2008 | * | St. Joseph's | 6 | at | LaSalle | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Temple | 5 | at | St. Louis | 0 | FINAL | Box Score | Recap | |
| Atlantic Coast Conference |
| 5/17/2008 | * | #2 North Carolina | 12 | at | #1 Miami, Florida | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #23 North Carolina State | 1 | at | #3 Florida State | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #29 Georgia Tech | 9 | at | Virginia | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Duke | 7 | at | Virginia Tech | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Wake Forest | 7 | at | Boston College | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Clemson | 8 | at | UCF | 5 | FINAL | Box Score | Recap | |
| Atlantic Sun Conference |
| 5/17/2008 | * | Stetson | 16 | at | East Tennessee State | 15 | FINAL | Box Score | Recap | |
| Big 10 Conference |
| 5/17/2008 | * | Northwestern | 2 | at | #22 Michigan | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Indiana | 14 | at | Michigan State | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Ohio State | 9 | at | Iowa | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Penn State | 2 | at | Minnesota | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Purdue | 0 | at | Illinois | 2 | FINAL | Box Score | Recap | 7 innings (makeup of 5/15 game) |
| 5/17/2008 | * | Purdue | 11 | at | Illinois | 2 | FINAL | Box Score | Recap | |
| Big 12 Conference |
| 5/17/2008 | * | #6 Nebraska | 9 | at | #15 Missouri | 22 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #28 Texas | 5 | at | #7 Texas A&M | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #8 Oklahoma State | 11 | vs | Oklahoma | 1 | FINAL | Box Score | Recap | Oklahoma City, OK |
| 5/17/2008 | * | Baylor | 13 | at | Texas Tech | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Kansas | 4 | at | Kansas State | 5 | FINAL | Box Score | Recap | |
| Big East Conference |
| 5/17/2008 | * | Connecticut | 6 | at | Pittsburgh | 5 | FINAL | Box Score | Recap | 7 innings (makeup of 5/16 game) |
| 5/17/2008 | * | Connecticut | 8 | at | Pittsburgh | 5 | FINAL | Box Score | Recap | 7 innings |
| 5/17/2008 | * | Notre Dame | 8 | at | South Florida | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Rutgers | 13 | at | Louisville | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Seton Hall | 2 | at | Georgetown | 8 | FINAL | Box Score | Recap | 7 innings (makeup of 5/16 game) |
| 5/17/2008 | * | Seton Hall | 5 | at | Georgetown | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | St. John's | 7 | at | Villanova | 8 | FINAL | Box Score | Recap | 11 innings (makeup of 5/16 game) |
| 5/17/2008 | * | St. John's | 5 | at | Villanova | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | West Virginia | 9 | at | Cincinnati | 14 | FINAL | Box Score | Recap | |
| Big South Conference |
| 5/17/2008 | * | #14 Coastal Carolina | 18 | at | Radford | 8 | FINAL | Box Score | Recap | 500th win at CCU for Gary Gilmore |
| 5/17/2008 | * | Charleston Southern | 2 | at | VMI | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | High Point | 4 | at | Liberty | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Winthrop | 10 | at | North Carolina-Asheville | 1 | FINAL | Box Score | Recap | |
| Big West Conference |
| 5/17/2008 | * | #9 UC Irvine | 4 | at | UC Davis | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| San Diego State | 5 | at | #11 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #25 Long Beach State | 6 | at | Cal Poly | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Cal State Northridge | 10 | at | Pacific | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | UC Riverside | 4 | at | UC Santa Barbara | 10 | FINAL | Box Score | Recap | |
| Colonial Athletic Association |
| 5/17/2008 | * | Old Dominion | 3 | at | #26 North Carolina-Wilmington | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Georgia State | 2 | at | Towson | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | James Madison | 6 | at | Northeastern | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | William and Mary | 3 | at | George Mason | 10 | FINAL | Box Score | Recap | makeup of 5/16 game |
| Conference USA |
| 5/17/2008 | * | #27 Southern Mississippi | 2 | at | Alabama-Birmingham | 12 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/17/2008 | * | #30 East Carolina | 5 | at | Memphis | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Marshall | 5 | at | Houston | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Clemson | 8 | at | UCF | 5 | FINAL | Box Score | Recap | |
| Division I Independents |
| 5/17/2008 |
| Dallas Baptist | 7 | at | San Francisco | 6 | FINAL | Box Score | Recap | 10 innings |
| 5/17/2008 |
| New Jersey Tech | 3 | at | Wright State | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Northern Colorado | 2 | at | New York Tech | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Presbyterian | 1 | at | The Citadel | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Utah Valley State | 2 | at | Hawaii | 0 | FINAL | Box Score | Recap | |
| Horizon League |
| 5/17/2008 | * | Cleveland State | 1 | at | Butler | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Cleveland State | 5 | at | Butler | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Valparaiso | 7 | at | Illinois-Chicago | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Valparaiso | 6 | at | Illinois-Chicago | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| New Jersey Tech | 3 | at | Wright State | 10 | FINAL | Box Score | Recap | |
| Metro Atlantic Athletic Conference |
| 5/17/2008 | * | Manhattan | 16 | at | Fairfield | 3 | FINAL | Box Score | Recap | makeup of 5/16 game |
| 5/17/2008 | * | Rider | 2 | at | St. Peter's | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Rider | 7 | at | St. Peter's | 4 | FINAL | Box Score | Recap | 7 innings |
| Mid American Conference |
| 5/17/2008 | * | Ball State | 11 | at | Toledo | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Bowling Green State | 4 | at | Akron | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Eastern Michigan | 5 | at | Central Michigan | 16 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Kent State | 8 | at | Miami, Ohio | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Ohio | 15 | at | Buffalo | 13 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Western Michigan | 5 | at | Northern Illinois | 8 | FINAL | Box Score | Recap | |
| Mid-Eastern Athletic Conference |
| 5/17/2008 | MEAC-09 | Norfolk State | 10 | vs | North Carolina A&T | 5 | FINAL | Box Score | Recap | MEAC Tournament, Game 9 (Norfolk, VA) |
| 5/17/2008 | MEAC-08 | North Carolina A&T | 2 | vs | Bethune-Cookman | 3 | FINAL | Box Score | Recap | MEAC Tournament, Game 8 (Norfolk, VA) |
| 5/17/2008 | MEAC-07 | Florida A&M | 2 | vs | Norfolk State | 5 | FINAL | Box Score | Recap | MEAC Tournament, Game 7 (Norfolk, VA) |
| Missouri Valley Conference |
| 5/17/2008 | * | Bradley | 5 | at | #18 Wichita State | 21 | FINAL | Box Score | Recap | 7 innings, run rule |
| 5/17/2008 | * | Evansville | 2 | at | Southern Illinois | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Illinois State | 8 | at | Indiana State | 12 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Missouri State | 5 | at | Northern Iowa | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Louisiana-Monroe | 7 | at | Creighton | 2 | FINAL | Box Score | Recap | |
| Mountain West Conference |
| 5/17/2008 |
| San Diego State | 5 | at | #11 Cal State Fullerton | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Brigham Young | 13 | at | Utah | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Nevada-Las Vegas | 2 | at | Air Force | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Texas Christian | 13 | at | New Mexico | 4 | FINAL | Box Score | Recap | |
| Northeast Conference |
| 5/17/2008 | * | Central Connecticut State | 9 | at | Fairleigh Dickinson | 12 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Central Connecticut State | 7 | at | Fairleigh Dickinson | 4 | FINAL | Box Score | Recap | 7 innings |
| 5/17/2008 | * | Monmouth | 9 | at | Long Island | 4 | FINAL | Box Score | Recap | Brooklyn, NY |
| 5/17/2008 | * | Monmouth |
| at | Long Island |
| Canceled | | Recap | CCD, field conditions (Brooklyn, NY) |
| 5/17/2008 | * | Mount St. Mary's | 4 | at | Quinnipiac | 1 | FINAL | Box Score | Recap | 7 innings (makeup of 5/16 game) |
| 5/17/2008 | * | Mount St. Mary's | 6 | at | Quinnipiac | 11 | FINAL | Box Score | Recap | makeup of 5/16 game |
| 5/17/2008 | * | Sacred Heart | 0 | at | Wagner | 8 | FINAL | Box Score | Recap | Piscataway, NJ |
| 5/17/2008 | * | Sacred Heart | 4 | at | Wagner | 10 | FINAL | Box Score | Recap | 7 innings (Piscataway, NJ) |
| Ohio Valley Conference |
| 5/17/2008 | * | Eastern Illinois | 20 | at | Eastern Kentucky | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Jacksonville State | 15 | at | Tennessee-Martin | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Murray State | 11 | at | Austin Peay State | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Samford | 6 | at | Tennessee Tech | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Southeast Missouri State | 12 | at | Morehead State | 13 | FINAL | Box Score | Recap | 10 innings |
| Pac 10 Conference |
| 5/17/2008 | * | Washington | 4 | at | #4 Arizona State | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #21 Stanford | 6 | at | #16 Arizona | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Oregon State | 2 | at | Southern California | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Washington State | 6 | at | UCLA | 7 | FINAL | Box Score | Recap | 10 innings |
| Patriot League |
| 5/17/2008 | PATRIOT-08 | Navy | 7 | vs | Bucknell | 8 | FINAL | Box Score | Recap | Patriot Championship, Game 2 (Annapolis, MD) |
| Southeastern Conference |
| 5/17/2008 | * | Alabama | 16 | at | #12 Georgia | 13 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | #13 Vanderbilt | 12 | at | Florida | 13 | FINAL | Box Score | Recap | 11 innings |
| 5/17/2008 | * | Tennessee | 8 | at | #19 South Carolina | 10 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Mississippi | 7 | at | #20 Kentucky | 5 | FINAL | Box Score | Recap | 11 innings |
| 5/17/2008 | * | #24 Louisiana State | 11 | at | Auburn | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Arkansas | 15 | at | Mississippi State | 10 | FINAL | Box Score | Recap | |
| Southern Conference |
| 5/17/2008 | * | Appalachian State | 7 | at | Wofford | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Appalachian State | 16 | at | Wofford | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | College of Charleston | 12 | at | Western Carolina | 13 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Georgia Southern | 5 | at | Furman | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Presbyterian | 1 | at | The Citadel | 11 | FINAL | Box Score | Recap | |
| Southland Conference |
| 5/17/2008 | * | McNeese State | 1 | at | Lamar | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Northwestern State | 2 | at | Central Arkansas | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Southeastern Louisiana | 3 | at | Nicholls State | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Southeastern Louisiana | 4 | at | Nicholls State | 1 | FINAL | Box Score | Recap | 7 innings (makeup of 5/16 game) |
| 5/17/2008 | * | Stephen F. Austin | 5 | at | Sam Houston State | 8 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Texas A&M-Corpus Christi | 5 | at | Texas-Arlington | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Texas-San Antonio | 8 | at | Texas State | 10 | FINAL | Box Score | Recap | |
| Southwestern Athletic Conference |
| 5/17/2008 | SWAC-10 | Prairie View A&M | 12 | vs | Alcorn State | 1 | FINAL | Box Score | Recap | 8 innings; SWAC Tournament, Game 10 (Baton Rouge, LA) |
| 5/17/2008 | SWAC-09 | Jackson State | 6 | vs | Mississippi Valley State | 4 | FINAL | Box Score | Recap | SWAC Tournament, Game 9 (Baton Rouge, LA) |
| 5/17/2008 | SWAC-08 | Southern | 14 | vs | Prairie View A&M | 9 | FINAL | Box Score | Recap | SWAC Tournament, Game 8 (Baton Rouge, LA) |
| Summit League |
| 5/17/2008 | * | Oral Roberts | 11 | at | IUPU-Fort Wayne | 1 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | South Dakota State | 4 | at | North Dakota State | 5 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Southern Utah | 11 | at | Oakland | 10 | FINAL | Box Score | Recap | 10 innings |
| 5/17/2008 | * | Western Illinois | 8 | at | Centenary | 5 | FINAL | Box Score | Recap | |
| Sun Belt Conference |
| 5/17/2008 | * | Arkansas-Little Rock | 8 | at | Arkansas State | 0 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Florida Atlantic | 10 | at | Florida International | 9 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Middle Tennessee State | 2 | at | Western Kentucky | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | New Orleans | 5 | at | Louisiana-Lafayette | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | South Alabama | 5 | at | Troy | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Louisiana-Monroe | 7 | at | Creighton | 2 | FINAL | Box Score | Recap | |
| West Coast Conference |
| 5/17/2008 | * | Gonzaga | 8 | at | Loyola Marymount | 7 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Pepperdine | 4 | at | Santa Clara | 1 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | St. Mary's | 16 | at | Portland | 3 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Dallas Baptist | 7 | at | San Francisco | 6 | FINAL | Box Score | Recap | 10 innings |
| Western Athletic Conference |
| 5/17/2008 | * | Fresno State | 0 | at | Cal State Sacramento | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Fresno State | 6 | at | Cal State Sacramento | 4 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Louisiana Tech | 7 | at | New Mexico State | 6 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Nevada | 0 | at | San Jose State | 2 | FINAL | Box Score | Recap | |
| 5/17/2008 | * | Nevada | 2 | at | San Jose State | 11 | FINAL | Box Score | Recap | |
| 5/17/2008 |
| Utah Valley State | 2 | at | Hawaii | 0 | FINAL | Box Score | Recap | |