| Game Date |
| Opponent | Conference Game | Result | Commentary |
| 2/22/2008 |
| Duquesne |
|
| PPD to 2/23, inclement weather |
| 2/23/2008 |
| Duquesne |
| W 14-3 | 7 innings (makeup of 2/22 game) |
| 2/23/2008 |
| Duquesne |
| W 15-3 | 7 innings |
| 2/24/2008 |
| Duquesne |
| W 15-3 | 8 innings, travel curfew |
| 2/28/2008 | at | Auburn |
| W 7-5 |
|
| 2/29/2008 | at | Auburn |
| W 6-5 |
|
| 3/1/2008 |
| Auburn |
| W 4-3 |
|
| 3/2/2008 |
| Auburn |
| W 10-1 |
|
| 3/4/2008 |
| North Carolina-Asheville |
| W 11-4 |
|
| 3/5/2008 |
| North Carolina-Asheville |
| W 10-5 |
|
| 3/7/2008 |
| Maryland | * |
| PPD to 3/8, inclement weather |
| 3/8/2008 |
| Maryland | * | W 5-4 | makeup of 3/7 game |
| 3/8/2008 |
| Maryland | * | W 16-0 |
|
| 3/9/2008 |
| Maryland | * | W 9-8 |
|
| 3/11/2008 |
| Georgia |
|
| Suspended to 3/12, rain (8-2 UGA, bottom 4) |
| 3/12/2008 |
| Georgia |
| L 13-10 | Resumption of 3/11 game |
| 3/12/2008 |
| Georgia |
| W 8-3 |
|
| 3/14/2008 |
| Georgia Tech | * | W 8-7 |
|
| 3/15/2008 |
| Georgia Tech | * | W 11-2 |
|
| 3/16/2008 |
| Georgia Tech | * | W 17-8 | 1,500th career win for FSU's Mike Martin |
| 3/18/2008 | at | Florida |
| L 6-1 |
|
| 3/21/2008 | at | Virginia Tech | * | W 9-4 |
|
| 3/22/2008 | at | Virginia Tech | * | W 12-11 |
|
| 3/23/2008 | at | Virginia Tech | * | W 18-12 |
|
| 3/25/2008 |
| Stetson |
| W 11-2 |
|
| 3/26/2008 |
| Stetson |
| W 19-3 |
|
| 3/28/2008 | at | Wake Forest | * | W 21-2 |
|
| 3/29/2008 | at | Wake Forest | * | L 4-2 |
|
| 3/30/2008 | at | Wake Forest | * | W 3-2 | 11 innings |
| 4/1/2008 | vs | Florida |
| W 10-2 | Jacksonville, FL |
| 4/2/2008 | at | Jacksonville |
| W 7-5 |
|
| 4/4/2008 |
| Virginia | * | W 10-3 |
|
| 4/5/2008 |
| Virginia | * |
| PPD to 4/6, rain |
| 4/6/2008 |
| Virginia | * | W 3-2 | 10 innings (makeup of 4/5 game) |
| 4/6/2008 |
| Virginia | * | W 3-2 | 10 innings |
| 4/11/2008 | at | Boston College | * | W 8-6 |
|
| 4/11/2008 | at | Boston College | * | W 4-3 | moved from 4/12, impending weather |
| 4/12/2008 | at | Boston College | * | W 17-2 | moved from 4/13 |
| 4/15/2008 |
| Florida |
| W 4-2 |
|
| 4/16/2008 |
| North Florida |
| W 10-2 |
|
| 4/18/2008 |
| Miami, Florida | * | L 11-4 |
|
| 4/19/2008 |
| Miami, Florida | * | W 9-5 |
|
| 4/20/2008 |
| Miami, Florida | * | L 11-10 | 7 innings, travel curfew |
| 4/25/2008 | at | North Carolina | * | L 11-4 |
|
| 4/26/2008 | at | North Carolina | * | W 13-5 |
|
| 4/27/2008 | at | North Carolina | * | L 2-1 | 10 innings |
| 4/29/2008 | at | Stetson |
| W 13-3 |
|
| 4/30/2008 | at | Stetson |
| W 6-3 |
|
| 5/3/2008 | at | Clemson | * | W 9-8 | 10 innings |
| 5/4/2008 | at | Clemson | * | W 13-4 |
|
| 5/5/2008 | at | Clemson | * | W 4-2 |
|
| 5/7/2008 |
| Jacksonville |
| L 7-6 |
|
| 5/9/2008 |
| Savannah State |
| W 23-4 | 7 innings, run rule |
| 5/10/2008 |
| Savannah State |
| W 19-2 | 7 innings, run rule |
| 5/11/2008 |
| Savannah State |
| W 24-4 | 7 innings, run rule |
| 5/12/2008 |
| Savannah State |
| W 10-0 | FSU's Buster Posey played all 9 positions (7 innings, run rule) |
| 5/15/2008 |
| North Carolina State | * | L 12-2 |
|
| 5/16/2008 |
| North Carolina State | * | W 1-0 |
|
| 5/17/2008 |
| North Carolina State | * | W 8-1 |
|
| 5/21/2008 | vs | Wake Forest | ACC-03 | W 8-3 | ACC Tournament, Game 3 (Jacksonville, FL) |
| 5/23/2008 | vs | Virginia | ACC-07 | L 5-3 | ACC Tournament, Game 6 (Jacksonville, FL) |
| 5/24/2008 | vs | North Carolina | ACC-11 | W 9-6 | ACC Tournament, Game 11 (Jacksonville, FL) |
| 5/30/2008 | vs | Bucknell |
| L 7-0 | Tallahassee Regional, Game 2 |
| 5/31/2008 | vs | Florida |
| W 17-11 | Tallahassee Regional, Game 3 |
| 6/1/2008 | vs | Bucknell |
| W 24-9 | Tallahassee Regional, Game 5 |
| 6/1/2008 | vs | Tulane |
| W 17-8 | Tallahassee Regional, Game 6 |
| 6/2/2008 | vs | Tulane |
| W 16-7 | Tallahassee Regional, Game 7 |
| 6/6/2008 | vs | Wichita State |
| L 10-7 | Tallahassee Super Regional, Game 1 |
| 6/7/2008 | vs | Wichita State |
| W 14-4 | Tallahassee Super Regional, Game 2 |
| 6/8/2008 | vs | Wichita State |
| W 11-4 | Tallahassee Super Regional, Game 3 |
| 6/14/2008 | vs | Stanford |
| L 16-5 | College World Series, Game 1 |
| 6/16/2008 | vs | Miami, Florida |
| L 7-5 | College World Series, Game 5 |